apelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

March 20, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

MM07 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

apelin-17, Elabela/Toddler-11, Elabela/Toddler-32, [Pyr1]apelin-13, apelin-13, apelin-36, Elabela/Toddler-21, apelin receptor early endogenous ligand



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic H8 R 315 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 R 315 8x49 G.H5 F 354 G.H5.26
Hydrophobic ICL1 R 62 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 62 - G.H5 D 350 G.H5.22
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 141 - G.H5 C 351 G.H5.23
Hydrophobic TM6 E 238 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 A 138 - G.hns1 R 32 G.hns1.03
Hydrophobic TM2 A 64 2x39 G.H5 C 351 G.H5.23
Polar TM5 H 231 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 131 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 131 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 H 231 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 135 - G.S3 L 194 G.S3.01
Ionic TM5 H 231 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 231 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Ionic ICL2 R 141 - G.H5 D 350 G.H5.22
Polar ICL2 R 141 - G.H5 D 350 G.H5.22
Hydrophobic TM6 E 238 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 E 238 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic H8 D 313 8x47 G.H5 F 354 G.H5.26
Van-der-waals H8 D 313 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 P 314 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 314 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL1 R 62 - G.H5 G 352 G.H5.24
Hydrophobic TM6 I 249 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 228 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 134 - G.H5 I 343 G.H5.15
Hydrophobic TM5 T 227 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 130 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM7 F 312 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM4 L 142 4x38 G.HN E 28 G.HN.52
Polar H8 R 315 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 R 315 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM6 L 246 6x33 G.H5 F 354 G.H5.26
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Ionic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 246 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 139 - G.hns1 R 32 G.hns1.03
Ionic TM6 R 236 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 236 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 236 6x23 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 242 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 F 232 5x69 G.H5 L 348 G.H5.20
Van-der-waals TM5 F 232 5x69 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 134 - G.H5 I 344 G.H5.16
Polar TM6 R 236 6x23 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 R 236 6x23 G.h4s6 K 314 G.h4s6.08
Polar ICL1 S 63 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 S 63 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 S 63 - G.H5 D 350 G.H5.22
Aromatic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Hydrophobic TM5 F 232 5x69 G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 135 - G.H5 I 343 G.H5.15
Hydrophobic TM5 I 224 5x61 G.H5 L 353 G.H5.25