Refined structure (8KFX) of Gi1 - CCR8

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (63.6%), 129 from model (36.4%)
Residue sidechains - 221 from structure (62.4%), 133 from model (37.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 287 from structure (87.8%), 40 from model (12.2%)
Residue sidechains - 287 from structure (87.8%), 40 from model (12.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 Y - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 D - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 V - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 T - AF2 AF2
N-term 12 V - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 D - AF2 AF2
N-term 15 Y - AF2 AF2
N-term 16 Y - AF2 AF2
N-term 17 Y - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 D - AF2 AF2
N-term 20 I - AF2 AF2
N-term 21 F - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 C - AF2 AF2
N-term 26 D - AF2 AF2
N-term 27 A - AF2 AF2
N-term 28 E - AF2 AF2
N-term 29 L - AF2 AF2
N-term 30 I - AF2 AF2
TM1 31 Q 1.28x28 Structure Structure
TM1 32 T 1.29x29 Structure Structure
TM1 33 N 1.30x30 Structure Structure
TM1 34 G 1.31x31 Structure Structure
TM1 35 K 1.32x32 Structure Structure
TM1 36 L 1.33x33 Structure Structure
TM1 37 L 1.34x34 Structure Structure
TM1 38 L 1.35x35 Structure Structure
TM1 39 A 1.36x36 Structure Structure
TM1 40 V 1.37x37 Structure Structure
TM1 41 F 1.38x38 Structure Structure
TM1 42 Y 1.39x39 Structure Structure
TM1 43 C 1.40x40 Structure Structure
TM1 44 L 1.41x41 Structure Structure
TM1 45 L 1.42x42 Structure Structure
TM1 46 F 1.43x43 Structure Structure
TM1 47 V 1.44x44 Structure Structure
TM1 48 F 1.45x45 Structure Structure
TM1 49 S 1.46x46 Structure Structure
TM1 50 L 1.47x47 Structure Structure
TM1 51 L 1.48x48 Structure Structure
TM1 52 G 1.49x49 Structure Structure
TM1 53 N 1.50x50 Structure Structure
TM1 54 S 1.51x51 Structure Structure
TM1 55 L 1.52x52 Structure Structure
TM1 56 V 1.53x53 Structure Structure
TM1 57 I 1.54x54 Structure Structure
TM1 58 L 1.55x55 Structure Structure
TM1 59 V 1.56x56 Structure Structure
TM1 60 L 1.57x57 Structure Structure
TM1 61 V 1.58x58 Structure Structure
TM1 62 V 1.59x59 Structure Structure
TM1 63 C 1.60x60 Structure Structure
ICL1 64 K 12.48x48 Structure Structure
ICL1 65 K 12.49x49 Structure Structure
ICL1 66 L 12.50x50 Structure Structure
ICL1 67 R 12.51x51 Structure Structure
TM2 68 S 2.37x37 Structure Structure
TM2 69 I 2.38x38 Structure Structure
TM2 70 T 2.39x39 Structure Structure
TM2 71 D 2.40x40 Structure Structure
TM2 72 V 2.41x41 Structure Structure
TM2 73 Y 2.42x42 Structure Structure
TM2 74 L 2.43x43 Structure Structure
TM2 75 L 2.44x44 Structure Structure
TM2 76 N 2.45x45 Structure Structure
TM2 77 L 2.46x46 Structure Structure
TM2 78 A 2.47x47 Structure Structure
TM2 79 L 2.48x48 Structure Structure
TM2 80 S 2.49x49 Structure Structure
TM2 81 D 2.50x50 Structure Structure
TM2 82 L 2.51x51 Structure Structure
TM2 83 L 2.52x52 Structure Structure
TM2 84 F 2.53x53 Structure Structure
TM2 85 V 2.54x54 Structure Structure
TM2 86 F 2.55x55 Structure Structure
TM2 87 S 2.56x56 Structure Structure
TM2 88 F 2.57x57 Structure Structure
TM2 89 P 2.58x58 Structure Structure
TM2 90 F 2.59x59 Structure Structure
TM2 91 Q 2.60x60 Structure Structure
TM2 92 T 2.61x61 Structure Structure
TM2 93 Y 2.62x62 Structure Structure
TM2 94 Y 2.63x63 Structure Structure
TM2 95 L 2.64x64 Structure Structure
TM2 96 L 2.65x65 Structure Structure
TM2 97 D 2.66x66 Structure Structure
ECL1 98 Q 23.49x49 Structure Structure
ECL1 99 W 23.50x50 Structure Structure
ECL1 100 V 23.51x51 Structure Structure
ECL1 101 F 23.52x52 Structure Structure
TM3 102 G 3.21x21 Structure Structure
TM3 103 T 3.22x22 Structure Structure
TM3 104 V 3.23x23 Structure Structure
TM3 105 M 3.24x24 Structure Structure
TM3 106 C 3.25x25 Structure Structure
TM3 107 K 3.26x26 Structure Structure
TM3 108 V 3.27x27 Structure Structure
TM3 109 V 3.28x28 Structure Structure
TM3 110 S 3.29x29 Structure Structure
TM3 111 G 3.30x30 Structure Structure
TM3 112 F 3.31x31 Structure Structure
TM3 113 Y 3.32x32 Structure Structure
TM3 114 Y 3.33x33 Structure Structure
TM3 115 I 3.34x34 Structure Structure
TM3 116 G 3.35x35 Structure Structure
TM3 117 F 3.36x36 Structure Structure
TM3 118 Y 3.37x37 Structure Structure
TM3 119 S 3.38x38 Structure Structure
TM3 120 S 3.39x39 Structure Structure
TM3 121 M 3.40x40 Structure Structure
TM3 122 F 3.41x41 Structure Structure
TM3 123 F 3.42x42 Structure Structure
TM3 124 I 3.43x43 Structure Structure
TM3 125 T 3.44x44 Structure Structure
TM3 126 L 3.45x45 Structure Structure
TM3 127 M 3.46x46 Structure Structure
TM3 128 S 3.47x47 Structure Structure
TM3 129 V 3.48x48 Structure Structure
TM3 130 D 3.49x49 Structure Structure
TM3 131 R 3.50x50 Structure Structure
TM3 132 Y 3.51x51 Structure Structure
TM3 133 L 3.52x52 Structure Structure
TM3 134 A 3.53x53 Structure Structure
TM3 135 V 3.54x54 Structure Structure
TM3 136 V 3.55x55 Structure Structure
TM3 137 H 3.56x56 Structure Structure
ICL2 138 A 34.50x50 Structure Structure
ICL2 139 V 34.51x51 Structure Structure
ICL2 140 Y 34.52x52 Structure Structure
ICL2 141 A 34.53x53 Structure Structure
ICL2 142 L 34.54x54 Structure Structure
ICL2 143 K 34.55x55 Structure Structure
ICL2 144 V 34.56x56 Structure Structure
ICL2 145 R 34.57x57 Structure Structure
TM4 146 T 4.38x38 Structure Structure
TM4 147 I 4.39x39 Structure Structure
TM4 148 R 4.40x40 Structure Structure
TM4 149 M 4.41x41 Structure Structure
TM4 150 G 4.42x42 Structure Structure
TM4 151 T 4.43x43 Structure Structure
TM4 152 T 4.44x44 Structure Structure
TM4 153 L 4.45x45 Structure Structure
TM4 154 C 4.46x46 Structure Structure
TM4 155 L 4.47x47 Structure Structure
TM4 156 A 4.48x48 Structure Structure
TM4 157 V 4.49x49 Structure Structure
TM4 158 W 4.50x50 Structure Structure
TM4 159 L 4.51x51 Structure Structure
TM4 160 T 4.52x52 Structure Structure
TM4 161 A 4.53x53 Structure Structure
TM4 162 I 4.54x54 Structure Structure
TM4 163 M 4.55x55 Structure Structure
TM4 164 A 4.56x56 Structure Structure
TM4 165 T 4.57x57 Structure Structure
TM4 166 I 4.58x59 Structure Structure
TM4 167 P 4.59x60 Structure Structure
TM4 168 L 4.60x61 Structure Structure
TM4 169 L 4.61x62 Structure Structure
TM4 170 V 4.62x63 Structure Structure
TM4 171 F 4.63x64 Structure Structure
TM4 172 Y 4.64x65 Structure Structure
ECL2 173 Q - Structure Structure
ECL2 174 V - Structure Structure
ECL2 175 A - Structure Structure
ECL2 176 S - Structure Structure
ECL2 177 E - Structure Structure
ECL2 178 D - Structure Structure
ECL2 179 G - Structure Structure
ECL2 180 V - Structure Structure
ECL2 181 L - Structure Structure
ECL2 182 Q - Structure Structure
ECL2 183 C 45.50x50 Structure Structure
ECL2 184 Y 45.51x51 Structure Structure
ECL2 185 S 45.52x52 Structure Structure
ECL2 186 F - Structure Structure
ECL2 187 Y - Structure Structure
ECL2 188 N - Structure Structure
ECL2 189 Q - Structure Structure
ECL2 190 Q - Structure Structure
TM5 191 T 5.31x32 Structure Structure
TM5 192 L 5.32x33 Structure Structure
TM5 193 K 5.33x34 Structure Structure
TM5 194 W 5.34x35 Structure Structure
TM5 195 K 5.35x36 Structure Structure
TM5 196 I 5.36x37 Structure Structure
TM5 197 F 5.37x38 Structure Structure
TM5 198 T 5.38x39 Structure Structure
TM5 199 N 5.39x40 Structure Structure
TM5 200 F 5.40x41 Structure Structure
TM5 201 K 5.41x42 Structure Structure
TM5 202 M 5.42x43 Structure Structure
TM5 203 N 5.43x44 Structure Structure
TM5 204 I 5.44x45 Structure Structure
TM5 205 L 5.45x46 Structure Structure
TM5 206 G 5.46x461 Structure Structure
TM5 207 L 5.47x47 Structure Structure
TM5 208 L 5.48x48 Structure Structure
TM5 209 I 5.49x49 Structure Structure
TM5 210 P 5.50x50 Structure Structure
TM5 211 F 5.51x51 Structure Structure
TM5 212 T 5.52x52 Structure Structure
TM5 213 I 5.53x53 Structure Structure
TM5 214 F 5.54x54 Structure Structure
TM5 215 M 5.55x55 Structure Structure
TM5 216 F 5.56x56 Structure Structure
TM5 217 C 5.57x57 Structure Structure
TM5 218 Y 5.58x58 Structure Structure
TM5 219 I 5.59x59 Structure Structure
TM5 220 K 5.60x60 Structure Structure
TM5 221 I 5.61x61 Structure Structure
TM5 222 L 5.62x62 Structure Structure
TM5 223 H 5.63x63 Structure Structure
TM5 224 Q 5.64x64 Structure Structure
TM5 225 L 5.65x65 Structure Structure
TM5 226 K 5.66x66 Structure Structure
TM5 227 R 5.67x67 Structure Structure
TM5 228 C 5.68x68 Structure Structure
ICL3 229 Q - Structure Structure
ICL3 230 N - Structure Structure
TM6 231 H 6.28x28 Structure Structure
TM6 232 N 6.29x29 Structure Structure
TM6 233 K 6.30x30 Structure Structure
TM6 234 T 6.31x31 Structure Structure
TM6 235 K 6.32x32 Structure Structure
TM6 236 A 6.33x33 Structure Structure
TM6 237 I 6.34x34 Structure Structure
TM6 238 R 6.35x35 Structure Structure
TM6 239 L 6.36x36 Structure Structure
TM6 240 V 6.37x37 Structure Structure
TM6 241 L 6.38x38 Structure Structure
TM6 242 I 6.39x39 Structure Structure
TM6 243 V 6.40x40 Structure Structure
TM6 244 V 6.41x41 Structure Structure
TM6 245 I 6.42x42 Structure Structure
TM6 246 A 6.43x43 Structure Structure
TM6 247 S 6.44x44 Structure Structure
TM6 248 L 6.45x45 Structure Structure
TM6 249 L 6.46x46 Structure Structure
TM6 250 F 6.47x47 Structure Structure
TM6 251 W 6.48x48 Structure Structure
TM6 252 V 6.49x49 Structure Structure
TM6 253 P 6.50x50 Structure Structure
TM6 254 F 6.51x51 Structure Structure
TM6 255 N 6.52x52 Structure Structure
TM6 256 V 6.53x53 Structure Structure
TM6 257 V 6.54x54 Structure Structure
TM6 258 L 6.55x55 Structure Structure
TM6 259 F 6.56x56 Structure Structure
TM6 260 L 6.57x57 Structure Structure
TM6 261 T 6.58x58 Structure Structure
TM6 262 S 6.59x59 Structure Structure
TM6 263 L 6.60x60 Structure Structure
TM6 264 H 6.61x61 Structure Structure
TM6 265 S 6.62x62 Structure Structure
TM6 266 M 6.63x63 Structure Structure
TM6 267 H 6.64x64 Structure Structure
TM6 268 I 6.65x65 Structure Structure
ECL3 269 L - Structure Structure
ECL3 270 D - Structure Structure
TM7 271 G 7.24x23 Structure Structure
TM7 272 C 7.25x24 Structure Structure
TM7 273 S 7.26x25 Structure Structure
TM7 274 I 7.27x26 Structure Structure
TM7 275 S 7.28x27 Structure Structure
TM7 276 Q 7.29x28 Structure Structure
TM7 277 Q 7.30x29 Structure Structure
TM7 278 L 7.31x30 Structure Structure
TM7 279 T 7.32x31 Structure Structure
TM7 280 Y 7.33x32 Structure Structure
TM7 281 A 7.34x33 Structure Structure
TM7 282 T 7.35x34 Structure Structure
TM7 283 H 7.36x35 Structure Structure
TM7 284 V 7.37x36 Structure Structure
TM7 285 T 7.38x37 Structure Structure
TM7 286 E 7.39x38 Structure Structure
TM7 287 I 7.40x39 Structure Structure
TM7 288 I 7.41x40 Structure Structure
TM7 289 S 7.42x41 Structure Structure
TM7 290 F 7.43x42 Structure Structure
TM7 291 T 7.44x43 Structure Structure
TM7 292 H 7.45x45 Structure Structure
TM7 293 C 7.46x46 Structure Structure
TM7 294 C 7.47x47 Structure Structure
TM7 295 V 7.48x48 Structure Structure
TM7 296 N 7.49x49 Structure Structure
TM7 297 P 7.50x50 Structure Structure
TM7 298 V 7.51x51 Structure Structure
TM7 299 I 7.52x52 Structure Structure
TM7 300 Y 7.53x53 Structure Structure
TM7 301 A 7.54x54 Structure Structure
TM7 302 F 7.55x55 Structure Structure
TM7 303 V 7.56x56 Structure Structure
H8 304 G 8.47x47 Structure Structure
H8 305 E 8.48x48 Structure Structure
H8 306 K 8.49x49 Structure Structure
H8 307 F 8.50x50 Structure Structure
H8 308 K 8.51x51 Structure Structure
H8 309 K 8.52x52 Structure Structure
H8 310 H 8.53x53 Structure Structure
H8 311 L 8.54x54 Structure Structure
H8 312 S 8.55x55 Structure Structure
H8 313 E 8.56x56 Structure Structure
H8 314 I 8.57x57 Structure Structure
H8 315 F 8.58x58 Structure Structure
H8 316 Q 8.59x59 Structure Structure
H8 317 K 8.60x60 Structure Structure
C-term 318 S - AF2 AF2
C-term 319 C - AF2 AF2
C-term 320 S - AF2 AF2
C-term 321 Q - AF2 AF2
C-term 322 I - AF2 AF2
C-term 323 F - AF2 AF2
C-term 324 N - AF2 AF2
C-term 325 Y - AF2 AF2
C-term 326 L - AF2 AF2
C-term 327 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 239 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 236 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 135 3x54 G.H5 L 348 G.H5.20
Hydrophobic H8 E 305 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 305 8x48 G.H5 F 354 G.H5.26
Polar TM3 D 130 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 225 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 225 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 143 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 143 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 134 3x53 G.H5 C 351 G.H5.23
Polar TM2 S 68 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 68 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 68 2x37 G.H5 D 350 G.H5.22
Ionic H8 K 306 8x49 G.H5 D 350 G.H5.22
Polar H8 K 306 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 306 8x49 G.H5 D 350 G.H5.22
Polar TM3 A 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 139 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 H 231 6x28 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 H 231 6x28 G.h4s6 D 315 G.h4s6.09
Polar ICL3 N 230 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 N 230 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 230 - G.h4s6 E 318 G.h4s6.12
Ionic ICL2 R 145 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 145 34x57 G.H5 D 350 G.H5.22
Polar TM6 A 236 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 236 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 236 6x33 G.H5 L 353 G.H5.25
Polar TM5 C 228 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 C 228 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 C 228 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL3 Q 229 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 229 - G.h4s6 E 318 G.h4s6.12
Polar TM6 H 231 6x28 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 H 231 6x28 G.h4s6 K 317 G.h4s6.11
Polar TM4 T 146 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 A 138 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 239 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 L 239 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 K 235 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 235 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 240 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 240 6x37 G.H5 L 353 G.H5.25
Ionic H8 E 305 8x48 G.H5 K 349 G.H5.21
Polar H8 E 305 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 E 305 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 E 305 8x48 G.H5 K 349 G.H5.21
Hydrophobic ICL2 V 139 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 139 34x51 G.s2s3 D 193 G.s2s3.02
Polar TM6 H 231 6x28 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 H 231 6x28 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 H 231 6x28 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 L 142 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 142 34x54 G.hns1 R 32 G.hns1.03
Polar ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 145 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 70 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 70 2x39 G.H5 C 351 G.H5.23
Polar ICL3 Q 229 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 Q 229 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 Q 229 - G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 224 5x64 G.H5 I 344 G.H5.16
Ionic TM6 H 231 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 231 6x28 G.h4s6 E 318 G.h4s6.12
Polar ICL3 N 230 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 N 230 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 N 230 - G.H5 D 341 G.H5.13
Polar TM2 T 70 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 70 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 70 2x39 G.H5 D 350 G.H5.22
Polar TM6 N 232 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 N 232 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 232 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 142 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 142 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL3 N 230 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 N 230 - G.H5 K 345 G.H5.17
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 138 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 N 232 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 N 232 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM4 R 148 4x40 G.HN R 24 G.HN.48
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 139 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 L 194 G.S3.01
Ionic TM4 R 148 4x40 G.HN E 28 G.HN.52
Polar TM4 R 148 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 R 148 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 148 4x40 G.HN E 28 G.HN.52