Refined structure (7PIV) of Gs - MC4 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 183 from structure (46.4%), 211 from model (53.6%)
Residue sidechains - 174 from structure (44.2%), 220 from model (55.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 AF2 AF2
G.HN 13 R G.HN.30 Structure AF2
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 AF2 AF2
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 AF2 AF2
G.s1h1 52 G G.s1h1.06 AF2 AF2
G.H1 53 K G.H1.01 AF2 AF2
G.H1 54 S G.H1.02 AF2 AF2
G.H1 55 T G.H1.03 AF2 AF2
G.H1 56 I G.H1.04 AF2 AF2
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 AF2 AF2
G.S2 207 I G.S2.01 AF2 AF2
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 AF2 AF2
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 AF2 AF2
G.HG 296 L G.HG.03 AF2 AF2
G.HG 297 L G.HG.04 AF2 AF2
G.HG 298 A G.HG.05 AF2 AF2
G.HG 299 E G.HG.06 AF2 AF2
G.HG 300 K G.HG.07 AF2 AF2
G.HG 301 V G.HG.08 AF2 AF2
G.HG 302 L G.HG.09 AF2 AF2
G.HG 303 A G.HG.10 AF2 AF2
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 Structure AF2
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure AF2
G.HG 310 D G.HG.17 Structure AF2
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure AF2
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure AF2
G.hgh4 320 T G.hgh4.10 AF2 AF2
G.hgh4 321 P G.hgh4.11 AF2 AF2
G.hgh4 322 E G.hgh4.12 AF2 AF2
G.hgh4 323 D G.hgh4.13 AF2 AF2
G.hgh4 324 A G.hgh4.14 AF2 AF2
G.hgh4 325 T G.hgh4.15 AF2 AF2
G.hgh4 326 P G.hgh4.16 AF2 AF2
G.hgh4 327 E G.hgh4.17 AF2 AF2
G.hgh4 328 P G.hgh4.18 AF2 AF2
G.hgh4 329 G G.hgh4.19 AF2 AF2
G.hgh4 330 E G.hgh4.20 AF2 AF2
G.hgh4 331 D G.hgh4.21 AF2 AF2
G.H4 332 P G.H4.01 AF2 AF2
G.H4 333 R G.H4.02 AF2 AF2
G.H4 334 V G.H4.03 AF2 AF2
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure AF2
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure AF2
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure AF2
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 260 from structure (78.8%), 70 from model (21.2%)
Residue sidechains - 243 from structure (73.6%), 87 from model (26.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 V - AF2 AF2
N-term 3 N - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 H - AF2 AF2
N-term 7 R - AF2 AF2
N-term 8 G - AF2 AF2
N-term 9 M - AF2 AF2
N-term 10 H - AF2 AF2
N-term 11 T - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 H - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 W - AF2 AF2
N-term 17 N - AF2 AF2
N-term 18 R - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 S - AF2 AF2
N-term 21 Y - AF2 AF2
N-term 22 R - AF2 AF2
N-term 23 L - AF2 AF2
N-term 24 H - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 N - AF2 AF2
N-term 27 A - AF2 AF2
N-term 28 S - AF2 AF2
N-term 29 E - AF2 AF2
N-term 30 S - AF2 AF2
N-term 31 L - AF2 AF2
N-term 32 G - AF2 AF2
N-term 33 K - AF2 AF2
N-term 34 G - AF2 AF2
N-term 35 Y - AF2 AF2
N-term 36 S - AF2 AF2
N-term 37 D - AF2 AF2
N-term 38 G - AF2 AF2
N-term 39 G - AF2 AF2
N-term 40 C - Structure Structure
N-term 41 Y - Structure AF2
N-term 42 E - Structure Structure
N-term 43 Q - Structure Structure
N-term 44 L - Structure Structure
N-term 45 F - Structure Structure
N-term 46 V - Structure Structure
TM1 47 S 1.35x35 Structure Structure
TM1 48 P 1.36x36 Structure Structure
TM1 49 E 1.37x37 Structure Structure
TM1 50 V 1.38x38 Structure Structure
TM1 51 F 1.39x39 Structure Structure
TM1 52 V 1.40x40 Structure Structure
TM1 53 T 1.41x41 Structure Structure
TM1 54 L 1.42x42 Structure Structure
TM1 55 G 1.43x43 Structure Structure
TM1 56 V 1.44x44 Structure Structure
TM1 57 I 1.45x45 Structure Structure
TM1 58 S 1.46x46 Structure Structure
TM1 59 L 1.47x47 Structure Structure
TM1 60 L 1.48x48 Structure Structure
TM1 61 E 1.49x49 Structure Structure
TM1 62 N 1.50x50 Structure Structure
TM1 63 I 1.51x51 Structure Structure
TM1 64 L 1.52x52 Structure Structure
TM1 65 V 1.53x53 Structure Structure
TM1 66 I 1.54x54 Structure Structure
TM1 67 V 1.55x55 Structure Structure
TM1 68 A 1.56x56 Structure Structure
TM1 69 I 1.57x57 Structure Structure
TM1 70 A 1.58x58 Structure Structure
TM1 71 K 1.59x59 Structure Structure
TM1 72 N 1.60x60 Structure Structure
ICL1 73 K 12.48x48 Structure AF2
ICL1 74 N 12.49x49 Structure AF2
ICL1 75 L 12.50x50 Structure Structure
ICL1 76 H 12.51x51 Structure AF2
TM2 77 S 2.37x37 Structure Structure
TM2 78 P 2.38x38 Structure Structure
TM2 79 M 2.39x39 Structure Structure
TM2 80 Y 2.40x40 Structure Structure
TM2 81 F 2.41x41 Structure Structure
TM2 82 F 2.42x42 Structure Structure
TM2 83 I 2.43x43 Structure Structure
TM2 84 C 2.44x44 Structure Structure
TM2 85 S 2.45x45 Structure Structure
TM2 86 L 2.46x46 Structure Structure
TM2 87 A 2.47x47 Structure Structure
TM2 88 V 2.48x48 Structure Structure
TM2 89 A 2.49x49 Structure Structure
TM2 90 D 2.50x50 Structure AF2
TM2 91 M 2.51x51 Structure Structure
TM2 92 L 2.52x52 Structure Structure
TM2 93 V 2.53x53 Structure Structure
TM2 94 S 2.54x54 Structure Structure
TM2 95 V 2.55x55 Structure Structure
TM2 96 S 2.56x56 Structure Structure
TM2 97 N 2.57x57 Structure Structure
TM2 98 G 2.58x58 Structure Structure
TM2 99 S 2.59x59 Structure Structure
TM2 100 E 2.60x60 Structure Structure
TM2 101 T 2.61x61 Structure Structure
TM2 102 I 2.62x62 Structure AF2
TM2 103 V 2.63x63 Structure Structure
TM2 104 I 2.64x64 Structure Structure
TM2 105 T 2.65x65 Structure AF2
TM2 106 L 2.66x66 Structure AF2
TM2 107 L 2.67x67 Structure AF2
ECL1 108 N - Structure Structure
ECL1 109 S - AF2 AF2
ECL1 110 T - AF2 AF2
ECL1 111 D - AF2 AF2
ECL1 112 T - AF2 AF2
ECL1 113 D - AF2 AF2
ECL1 114 A - AF2 AF2
TM3 115 Q 3.18x18 AF2 AF2
TM3 116 S 3.19x19 AF2 AF2
TM3 117 F 3.20x20 AF2 AF2
TM3 118 T 3.21x21 Structure AF2
TM3 119 V 3.22x22 Structure AF2
TM3 120 N 3.23x23 Structure AF2
TM3 121 I 3.24x24 Structure AF2
TM3 122 D 3.25x25 Structure Structure
TM3 123 N 3.26x26 Structure Structure
TM3 124 V 3.27x27 Structure AF2
TM3 125 I 3.28x28 Structure Structure
TM3 126 D 3.29x29 Structure Structure
TM3 127 S 3.30x30 Structure Structure
TM3 128 V 3.31x31 Structure Structure
TM3 129 I 3.32x32 Structure Structure
TM3 130 C 3.33x33 Structure Structure
TM3 131 S 3.34x34 Structure Structure
TM3 132 S 3.35x35 Structure Structure
TM3 133 L 3.36x36 Structure Structure
TM3 134 L 3.37x37 Structure Structure
TM3 135 A 3.38x38 Structure Structure
TM3 136 S 3.39x39 Structure Structure
TM3 137 I 3.40x40 Structure Structure
TM3 138 C 3.41x41 Structure Structure
TM3 139 S 3.42x42 Structure Structure
TM3 140 L 3.43x43 Structure Structure
TM3 141 L 3.44x44 Structure Structure
TM3 142 S 3.45x45 Structure Structure
TM3 143 I 3.46x46 Structure Structure
TM3 144 A 3.47x47 Structure Structure
TM3 145 V 3.48x48 Structure Structure
TM3 146 D 3.49x49 Structure Structure
TM3 147 R 3.50x50 Structure Structure
TM3 148 Y 3.51x51 Structure Structure
TM3 149 F 3.52x52 Structure Structure
TM3 150 T 3.53x53 Structure Structure
TM3 151 I 3.54x54 Structure Structure
TM3 152 F 3.55x55 Structure Structure
TM3 153 Y 3.56x56 Structure Structure
ICL2 154 A 34.50x50 Structure Structure
ICL2 155 L 34.51x51 Structure Structure
ICL2 156 Q 34.52x52 Structure Structure
ICL2 157 Y 34.53x53 Structure Structure
ICL2 158 H 34.54x54 Structure Structure
ICL2 159 N 34.55x55 Structure Structure
ICL2 160 I 34.56x56 Structure Structure
ICL2 161 M 34.57x57 Structure Structure
TM4 162 T 4.38x38 Structure Structure
TM4 163 V 4.39x39 Structure Structure
TM4 164 K 4.40x40 Structure Structure
TM4 165 R 4.41x41 Structure Structure
TM4 166 V 4.42x42 Structure Structure
TM4 167 G 4.43x43 Structure Structure
TM4 168 I 4.44x44 Structure Structure
TM4 169 I 4.45x45 Structure Structure
TM4 170 I 4.46x46 Structure Structure
TM4 171 S 4.47x47 Structure Structure
TM4 172 C 4.48x48 Structure Structure
TM4 173 I 4.49x49 Structure Structure
TM4 174 W 4.50x50 Structure Structure
TM4 175 A 4.51x51 Structure Structure
TM4 176 A 4.52x52 Structure Structure
TM4 177 C 4.53x53 Structure Structure
TM4 178 T 4.54x54 Structure Structure
TM4 179 V 4.55x55 Structure Structure
TM4 180 S 4.56x56 Structure Structure
TM4 181 G 4.57x57 Structure Structure
TM4 182 I 4.58x58 Structure Structure
TM4 183 L 4.59x59 Structure Structure
TM4 184 F 4.60x60 Structure Structure
TM4 185 I 4.61x61 Structure Structure
TM4 186 I 4.62x62 Structure Structure
TM4 187 Y 4.63x63 Structure Structure
TM4 188 S 4.64x64 Structure Structure
ECL2 189 D - Structure Structure
TM5 190 S 5.36x36 Structure Structure
TM5 191 S 5.37x37 Structure Structure
TM5 192 A 5.38x38 Structure Structure
TM5 193 V 5.39x39 Structure Structure
TM5 194 I 5.40x40 Structure Structure
TM5 195 I 5.41x41 Structure Structure
TM5 196 C 5.42x42 Structure Structure
TM5 197 L 5.43x43 Structure Structure
TM5 198 I 5.44x44 Structure Structure
TM5 199 T 5.45x45 Structure Structure
TM5 200 M 5.46x46 Structure Structure
TM5 201 F 5.47x47 Structure Structure
TM5 202 F 5.48x48 Structure Structure
TM5 203 T 5.49x49 Structure Structure
TM5 204 M 5.50x50 Structure Structure
TM5 205 L 5.51x51 Structure Structure
TM5 206 A 5.52x52 Structure Structure
TM5 207 L 5.53x53 Structure Structure
TM5 208 M 5.54x54 Structure Structure
TM5 209 A 5.55x55 Structure Structure
TM5 210 S 5.56x56 Structure Structure
TM5 211 L 5.57x57 Structure Structure
TM5 212 Y 5.58x58 Structure Structure
TM5 213 V 5.59x59 Structure Structure
TM5 214 H 5.60x60 Structure Structure
TM5 215 M 5.61x61 Structure Structure
TM5 216 F 5.62x62 Structure Structure
TM5 217 L 5.63x63 Structure Structure
TM5 218 M 5.64x64 Structure Structure
TM5 219 A 5.65x65 Structure Structure
TM5 220 R 5.66x66 Structure Structure
TM5 221 L 5.67x67 Structure Structure
TM5 222 H 5.68x68 Structure Structure
TM5 223 I 5.69x69 Structure Structure
TM5 224 K 5.70x70 Structure Structure
TM5 225 R 5.71x71 Structure Structure
TM5 226 I 5.72x72 Structure Structure
TM5 227 A 5.73x73 Structure Structure
TM5 228 V 5.74x74 Structure Structure
TM5 229 L 5.75x75 Structure Structure
ICL3 230 P - Structure Structure
ICL3 231 G - AF2 AF2
ICL3 232 T - AF2 AF2
ICL3 233 G - AF2 AF2
ICL3 234 A - AF2 AF2
ICL3 235 I - AF2 AF2
ICL3 236 R - AF2 AF2
TM6 237 Q 6.27x27 AF2 AF2
TM6 238 G 6.28x28 AF2 AF2
TM6 239 A 6.29x29 Structure Structure
TM6 240 N 6.30x30 Structure Structure
TM6 241 M 6.31x31 Structure Structure
TM6 242 K 6.32x32 Structure Structure
TM6 243 G 6.33x33 Structure Structure
TM6 244 A 6.34x34 Structure Structure
TM6 245 I 6.35x35 Structure Structure
TM6 246 T 6.36x36 Structure Structure
TM6 247 L 6.37x37 Structure Structure
TM6 248 T 6.38x38 Structure Structure
TM6 249 I 6.39x39 Structure Structure
TM6 250 L 6.40x40 Structure Structure
TM6 251 I 6.41x41 Structure Structure
TM6 252 G 6.42x42 Structure Structure
TM6 253 V 6.43x43 Structure Structure
TM6 254 F 6.44x44 Structure Structure
TM6 255 V 6.45x45 Structure Structure
TM6 256 V 6.46x46 Structure Structure
TM6 257 C 6.47x47 Structure Structure
TM6 258 W 6.48x48 Structure Structure
TM6 259 A 6.49x49 Structure Structure
TM6 260 P 6.50x50 Structure Structure
TM6 261 F 6.51x51 Structure Structure
TM6 262 F 6.52x52 Structure Structure
TM6 263 L 6.53x53 Structure Structure
TM6 264 H 6.54x54 Structure Structure
TM6 265 L 6.55x55 Structure Structure
TM6 266 I 6.56x56 Structure Structure
TM6 267 F 6.57x57 Structure Structure
TM6 268 Y 6.58x58 Structure Structure
TM6 269 I 6.59x59 Structure Structure
TM6 270 S 6.60x60 Structure Structure
TM6 271 C 6.61x61 Structure Structure
ECL3 272 P - Structure Structure
ECL3 273 Q - Structure Structure
ECL3 274 N - Structure Structure
ECL3 275 P - Structure Structure
ECL3 276 Y - Structure Structure
ECL3 277 C - Structure Structure
ECL3 278 V - Structure Structure
ECL3 279 C - Structure Structure
ECL3 280 F - Structure Structure
ECL3 281 M - Structure Structure
ECL3 282 S - Structure Structure
TM7 283 H 7.34x33 Structure Structure
TM7 284 F 7.35x34 Structure Structure
TM7 285 N 7.36x35 Structure Structure
TM7 286 L 7.37x36 Structure Structure
TM7 287 Y 7.38x37 Structure Structure
TM7 288 L 7.39x38 Structure Structure
TM7 289 I 7.40x39 Structure Structure
TM7 290 L 7.41x40 Structure Structure
TM7 291 I 7.42x41 Structure Structure
TM7 292 M 7.43x42 Structure Structure
TM7 293 C 7.44x43 Structure Structure
TM7 294 N 7.45x45 Structure Structure
TM7 295 S 7.46x46 Structure Structure
TM7 296 I 7.47x47 Structure Structure
TM7 297 I 7.48x48 Structure Structure
TM7 298 D 7.49x49 Structure Structure
TM7 299 P 7.50x50 Structure Structure
TM7 300 L 7.51x51 Structure Structure
TM7 301 I 7.52x52 Structure Structure
TM7 302 Y 7.53x53 Structure Structure
TM7 303 A 7.54x54 Structure Structure
TM7 304 L 7.55x55 Structure Structure
TM7 305 R 7.56x56 Structure Structure
H8 306 S 8.47x47 Structure Structure
H8 307 Q 8.48x48 Structure Structure
H8 308 E 8.49x49 Structure AF2
H8 309 L 8.50x50 Structure Structure
H8 310 R 8.51x51 Structure Structure
H8 311 K 8.52x52 Structure AF2
H8 312 T 8.53x53 Structure Structure
H8 313 F 8.54x54 Structure Structure
H8 314 K 8.55x55 Structure AF2
H8 315 E 8.56x56 Structure Structure
H8 316 I 8.57x57 Structure Structure
H8 317 I 8.58x58 AF2 AF2
H8 318 C 8.59x59 AF2 AF2
H8 319 C 8.60x60 AF2 AF2
H8 320 Y 8.61x61 AF2 AF2
C-term 321 P - AF2 AF2
C-term 322 L - AF2 AF2
C-term 323 G - AF2 AF2
C-term 324 G - AF2 AF2
C-term 325 L - AF2 AF2
C-term 326 C - AF2 AF2
C-term 327 D - AF2 AF2
C-term 328 L - AF2 AF2
C-term 329 S - AF2 AF2
C-term 330 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 H 222 5x68 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 154 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 A 219 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 219 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 226 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 A 154 34x50 G.H5 Q 384 G.H5.16
Polar TM5 H 222 5x68 G.H5 R 385 G.H5.17
Aromatic TM5 H 222 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 222 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 222 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 H 158 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 151 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 226 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 226 5x72 G.H5 R 385 G.H5.17
Ionic TM5 R 225 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 225 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 225 5x71 G.H5 D 381 G.H5.13
Polar TM6 T 246 6x36 G.H5 Y 391 G.H5.23
Polar ICL3 P 230 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 P 230 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 P 230 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 H 222 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 L 229 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM3 I 151 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 151 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 155 34x51 G.S1 H 41 G.S1.02
Polar TM5 L 229 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 L 229 5x75 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 L 229 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 L 155 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 155 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 155 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 K 242 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 G 243 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 243 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 F 216 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 222 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 H 158 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 H 158 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 A 219 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 A 219 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 223 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 I 223 5x69 G.H5 L 394 G.H5.26
Polar TM5 H 222 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 222 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 G 231 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 V 228 5x74 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 V 228 5x74 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 L 155 34x51 G.S3 V 217 G.S3.01
Van-der-waals TM5 R 225 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 215 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 215 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL3 P 230 - G.H4 L 346 G.H4.16
Hydrophobic ICL3 P 230 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 P 230 - G.H4 D 343 G.H4.13
Hydrophobic TM6 K 242 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 242 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 Q 156 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM3 R 147 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 147 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 T 232 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 T 232 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 T 246 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 246 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL3 P 230 - G.hgh4 P 321 G.hgh4.11
Hydrophobic TM6 T 246 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 246 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 A 219 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM2 M 79 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 T 150 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 T 150 3x53 G.H5 H 387 G.H5.19
Polar ICL2 N 159 34x55 G.HN Q 35 G.HN.52
Hydrophobic TM3 I 151 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 151 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 H 158 34x54 G.hns1 A 39 G.hns1.03
Polar TM4 T 162 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 T 162 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 162 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM7 R 305 7x56 G.H5 E 392 G.H5.24
Polar TM3 I 151 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 151 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 151 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 Q 156 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 Q 156 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM6 L 247 6x37 G.H5 L 393 G.H5.25
Polar TM3 T 150 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 150 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 N 159 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 P 230 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 P 230 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 L 155 34x51 G.H5 R 380 G.H5.12
Polar TM2 Y 80 2x40 G.H5 Q 390 G.H5.22