GPR35 - G13

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8H8J

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41421-022-00499-8

PUBLICATION DATE

Feb. 8, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

27 interactions (Click to see)

LIGANDS

lodoxamide - Agonist pubchem gtoplig chembl_ligand drug_central drugbank

PHYSIOLOGICAL LIGANDS

kynurenic acid, 2-oleoyl-LPA, 2-Oleoyllysophosphatydic acid, 1-Lyso-2-oleoyl-phosphatidic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL3 R 201 - G.H5 D 365 G.H5.13
Polar ICL3 R 201 - G.H5 D 365 G.H5.13
Hydrophobic ICL3 R 201 - G.H5 D 365 G.H5.13
Van-der-waals ICL3 R 201 - G.H5 D 365 G.H5.13
Hydrophobic TM5 L 198 5x65 G.H5 L 372 G.H5.20
Hydrophobic ICL2 P 121 - G.H5 K 364 G.H5.12
Van-der-waals ICL2 P 121 - G.H5 K 364 G.H5.12
Hydrophobic TM3 V 118 3x54 G.H5 L 368 G.H5.16
Van-der-waals TM3 V 118 3x54 G.H5 L 368 G.H5.16
Hydrophobic TM6 Q 208 6x26 G.h4s6 P 342 G.h4s6.20
Van-der-waals TM6 Q 208 6x26 G.h4s6 P 342 G.h4s6.20
Hydrophobic TM3 V 118 3x54 G.H5 L 372 G.H5.20
Hydrophobic ICL2 P 121 - G.H5 I 367 G.H5.15
Van-der-waals ICL2 P 121 - G.H5 I 367 G.H5.15
Polar ICL2 R 125 - G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 R 125 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 125 - G.hns1 K 46 G.hns1.02
Hydrophobic TM3 R 114 3x50 G.H5 L 377 G.H5.25
Van-der-waals TM3 R 114 3x50 G.H5 L 377 G.H5.25
Polar TM6 Q 208 6x26 G.h4s6 Q 339 G.h4s6.12
Van-der-waals TM6 Q 208 6x26 G.h4s6 Q 339 G.h4s6.12
Hydrophobic ICL4 A 280 - G.H5 M 376 G.H5.24
Van-der-waals ICL4 A 280 - G.H5 M 376 G.H5.24
Hydrophobic TM2 T 55 2x39 G.H5 M 376 G.H5.24
Polar TM6 Q 208 6x26 G.H5 H 369 G.H5.17
Hydrophobic TM6 Q 208 6x26 G.H5 H 369 G.H5.17
Van-der-waals TM6 Q 208 6x26 G.H5 H 369 G.H5.17
Hydrophobic TM3 D 113 3x49 G.H5 L 375 G.H5.23
Hydrophobic TM6 A 215 6x33 G.H5 L 372 G.H5.20
Hydrophobic ICL2 P 121 - G.H5 L 368 G.H5.16
Hydrophobic ICL2 L 122 - G.S1 V 49 G.S1.02
Hydrophobic TM6 V 219 6x37 G.H5 L 377 G.H5.25
Hydrophobic TM3 A 117 3x53 G.H5 N 371 G.H5.19
Hydrophobic H8 K 281 8x48 G.H5 Q 378 G.H5.26
Van-der-waals H8 K 281 8x48 G.H5 Q 378 G.H5.26
Hydrophobic ICL2 L 122 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 122 - G.S3 V 217 G.S3.01
Hydrophobic TM3 A 117 3x53 G.H5 L 375 G.H5.23
Hydrophobic ICL2 L 122 - G.H5 I 367 G.H5.15
Van-der-waals ICL2 L 122 - G.H5 I 367 G.H5.15
Hydrophobic TM2 T 55 2x39 G.H5 L 375 G.H5.23
Van-der-waals TM2 T 55 2x39 G.H5 L 375 G.H5.23
Hydrophobic ICL2 R 125 - G.H5 I 367 G.H5.15
Hydrophobic ICL2 L 122 - G.H5 K 364 G.H5.12
Van-der-waals ICL2 L 122 - G.H5 K 364 G.H5.12
Hydrophobic TM6 A 211 6x29 G.H5 Q 378 G.H5.26
Van-der-waals TM6 A 211 6x29 G.H5 Q 378 G.H5.26
Hydrophobic TM2 M 59 2x43 G.H5 M 376 G.H5.24
Van-der-waals TM2 M 59 2x43 G.H5 M 376 G.H5.24
Hydrophobic ICL2 L 122 - G.S3 F 219 G.S3.03
Polar TM2 T 55 2x39 G.H5 Q 374 G.H5.22
Van-der-waals TM2 T 55 2x39 G.H5 Q 374 G.H5.22
Hydrophobic ICL3 R 201 - G.H5 L 368 G.H5.16
Hydrophobic ICL3 P 202 - G.H5 D 365 G.H5.13
Van-der-waals ICL3 P 202 - G.H5 D 365 G.H5.13
Hydrophobic TM6 G 207 6x25 G.h4s6 Q 339 G.h4s6.12
Van-der-waals TM6 G 207 6x25 G.h4s6 Q 339 G.h4s6.12
Hydrophobic TM6 D 205 6x23 G.H4 R 332 G.H4.16
Hydrophobic ICL3 T 204 - G.S6 Y 344 G.S6.02
Hydrophobic ICL2 L 122 - G.H5 F 360 G.H5.08
Hydrophobic TM1 F 45 1x57 G.H5 M 376 G.H5.24
Van-der-waals TM1 F 45 1x57 G.H5 M 376 G.H5.24
Hydrophobic ICL2 R 123 - G.s2s3 N 216 G.s2s3.02
Van-der-waals ICL2 R 123 - G.s2s3 N 216 G.s2s3.02
Polar ICL2 R 123 - G.s2s3 K 215 G.s2s3.01
Hydrophobic ICL2 R 123 - G.s2s3 K 215 G.s2s3.01
Van-der-waals ICL2 R 123 - G.s2s3 K 215 G.s2s3.01
Hydrophobic ICL3 P 202 - G.H5 R 361 G.H5.09
Van-der-waals ICL3 P 202 - G.H5 R 361 G.H5.09
Hydrophobic TM6 M 218 6x36 G.H5 L 377 G.H5.25
Hydrophobic TM5 L 198 5x65 G.H5 L 368 G.H5.16
Van-der-waals TM5 L 198 5x65 G.H5 L 368 G.H5.16
Hydrophobic ICL2 R 128 - G.H5 L 375 G.H5.23
Van-der-waals ICL2 R 128 - G.H5 L 375 G.H5.23
Hydrophobic ICL2 R 125 - G.hns1 R 47 G.hns1.03
Hydrophobic TM3 R 114 3x50 G.H5 L 375 G.H5.23
Van-der-waals TM3 R 114 3x50 G.H5 L 375 G.H5.23
Hydrophobic H8 E 282 8x49 G.H5 M 376 G.H5.24
Hydrophobic TM6 A 215 6x33 G.H5 L 377 G.H5.25