Y2 receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

E

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8K6N

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

July 31, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

88 interactions (Click to see)

LIGANDS

neuropeptide Y - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig pubchem pubchem pubchem

PHYSIOLOGICAL LIGANDS

PYY-(3-36), peptide YY, pancreatic polypeptide, neuropeptide Y-(3-36), neuropeptide Y



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 P 252 - G.S6 Y 321 G.S6.02
Polar ICL2 K 159 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 K 159 - G.H5 N 348 G.H5.19
Polar TM3 C 151 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 C 151 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 C 151 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 T 266 6x33 G.H5 F 355 G.H5.26
Hydrophobic TM5 H 249 5x68 G.H5 I 345 G.H5.16
Ionic TM5 H 249 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 249 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 249 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM3 R 148 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM4 R 163 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 R 163 4x40 G.HN R 24 G.HN.48
Hydrophobic TM6 T 266 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 266 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 152 3x54 G.H5 C 352 G.H5.23
Polar H8 S 330 8x48 G.H5 G 353 G.H5.24
Hydrophobic H8 N 329 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 329 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM7 M 328 7x56 G.H5 L 354 G.H5.25
Van-der-waals TM7 M 328 7x56 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 242 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 148 3x50 G.H5 C 352 G.H5.23
Polar TM3 C 151 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 C 151 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 C 151 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 H 155 - G.H5 I 344 G.H5.15
Polar H8 S 330 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 S 330 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 S 330 8x48 G.H5 F 355 G.H5.26
Polar TM6 R 262 6x29 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 Y 259 6x26 G.H5 K 346 G.H5.17
Hydrophobic TM6 L 270 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 270 6x37 G.H5 L 354 G.H5.25
Polar ICL3 P 252 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 P 252 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 P 252 - G.H5 D 342 G.H5.13
Hydrophobic TM3 I 152 3x54 G.H5 N 348 G.H5.19
Van-der-waals TM3 I 152 3x54 G.H5 N 348 G.H5.19
Van-der-waals ICL2 H 155 - G.H5 N 348 G.H5.19
Aromatic TM6 R 262 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 262 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 262 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 Y 259 6x26 G.H5 F 355 G.H5.26
Hydrophobic ICL2 H 155 - G.H5 T 341 G.H5.12
Hydrophobic TM5 L 246 5x65 G.H5 I 345 G.H5.16
Van-der-waals TM5 L 246 5x65 G.H5 I 345 G.H5.16
Hydrophobic TM5 K 245 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 K 245 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 152 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 152 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 246 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 L 246 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 156 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 156 - G.S3 L 195 G.S3.01