GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7WCM

RESOLUTION

2.3 Å

REFERENCE

10.1038/S41467-022-34696-6

PUBLICATION DATE

Dec. 21, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

36 interactions (Click to see)

LIGANDS

MBX-2982 - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

anandamide, N-oleoylethanolamide, SEA, N-palmitoylethanolamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 226 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 111 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 F 111 34x51 G.H5 R 380 G.H5.12
Polar ICL2 K 115 34x55 G.s2s3 K 216 G.s2s3.02
Polar TM6 T 226 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 226 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 A 209 5x83 G.H4 R 347 G.H4.17
Van-der-waals TM5 A 209 5x83 G.H4 R 347 G.H4.17
Hydrophobic TM5 S 196 5x70 G.H5 L 394 G.H5.26
Aromatic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 111 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 114 34x54 G.S1 H 41 G.S1.02
Polar TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 E 203 5x77 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 G 210 5x84 G.H4 R 347 G.H4.17
Hydrophobic ICL2 F 111 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 199 5x73 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 110 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 205 5x79 G.H4 D 343 G.H4.13
Hydrophobic TM3 I 107 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 M 202 5x76 G.S6 P 361 G.S6.03
Hydrophobic TM5 M 202 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 I 191 5x65 G.H5 Q 384 G.H5.16
Aromatic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 I 199 5x73 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 M 202 5x76 G.H4 L 346 G.H4.16
Polar TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 195 5x69 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 195 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 K 201 5x75 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 A 192 5x66 G.H5 L 388 G.H5.20
Hydrophobic TM5 H 195 5x69 G.H5 L 388 G.H5.20
Ionic ICL1 D 37 - G.HN K 34 G.HN.51
Polar ICL1 D 37 - G.HN K 34 G.HN.51
Van-der-waals ICL1 D 37 - G.HN K 34 G.HN.51
Hydrophobic ICL2 P 110 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL4 W 282 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 W 282 - G.H5 E 392 G.H5.24
Hydrophobic TM5 G 206 5x80 G.H4 L 346 G.H4.16
Hydrophobic TM6 K 222 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 222 6x32 G.H5 L 394 G.H5.26
Ionic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Polar TM5 H 195 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 195 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 195 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 A 192 5x66 G.H5 L 393 G.H5.25
Aromatic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 103 3x50 G.H5 Y 391 G.H5.23
Polar TM6 K 222 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 222 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM3 A 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 111 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 G 206 5x80 G.H4 R 347 G.H4.17
Hydrophobic TM5 A 209 5x83 G.H4 D 343 G.H4.13
Van-der-waals TM5 A 209 5x83 G.H4 D 343 G.H4.13
Hydrophobic TM5 I 191 5x65 G.H5 L 388 G.H5.20
Polar TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 195 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 227 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 110 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 A 205 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM3 I 107 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 107 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 M 188 5x62 G.H5 L 393 G.H5.25
Hydrophobic ICL2 K 115 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 A 223 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 393 G.H5.25