ETA receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Aug. 28, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOTHELIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

endothelin-3, endothelin-2, endothelin-1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 D 182 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM6 V 304 6x33 G.H5 V 384 G.H5.26
Polar TM3 A 186 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 A 186 3x53 G.H5 N 377 G.H5.19
Van-der-waals TM3 A 186 3x53 G.H5 N 377 G.H5.19
Ionic TM6 H 297 6x26 G.H5 D 371 G.H5.13
Polar TM6 H 297 6x26 G.H5 D 371 G.H5.13
Hydrophobic TM6 H 297 6x26 G.H5 D 371 G.H5.13
Van-der-waals TM6 H 297 6x26 G.H5 D 371 G.H5.13
Aromatic TM6 H 297 6x26 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM6 H 297 6x26 G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL2 W 190 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 V 193 - G.H5 Y 381 G.H5.23
Aromatic ICL2 W 190 - G.H5 K 370 G.H5.12
Hydrophobic ICL2 W 190 - G.H5 K 370 G.H5.12
Van-der-waals ICL2 W 190 - G.H5 K 370 G.H5.12
Hydrophobic ICL2 W 190 - G.H5 C 369 G.H5.11
Hydrophobic TM6 H 297 6x26 G.H5 Q 375 G.H5.17
Hydrophobic TM3 V 187 3x54 G.H5 L 378 G.H5.20
Hydrophobic TM6 E 296 6x25 G.h4s6 Y 348 G.h4s6.20
Hydrophobic TM6 V 308 6x37 G.H5 L 383 G.H5.25
Hydrophobic TM3 R 183 3x50 G.H5 L 383 G.H5.25
Van-der-waals TM3 R 183 3x50 G.H5 L 383 G.H5.25
Hydrophobic ICL2 W 190 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 W 190 - G.H5 I 373 G.H5.15
Polar ICL2 Q 194 - G.H5 E 380 G.H5.22
Hydrophobic ICL2 Q 194 - G.H5 E 380 G.H5.22
Hydrophobic TM5 M 282 5x65 G.H5 L 378 G.H5.20
Van-der-waals TM5 M 282 5x65 G.H5 L 378 G.H5.20
Hydrophobic ICL2 S 191 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 S 191 - G.H5 I 373 G.H5.15
Hydrophobic H8 F 376 8x50 G.H5 N 382 G.H5.24
Van-der-waals H8 F 376 8x50 G.H5 N 382 G.H5.24
Hydrophobic TM6 Q 300 6x29 G.H5 V 384 G.H5.26
Van-der-waals TM6 Q 300 6x29 G.H5 V 384 G.H5.26
Hydrophobic ICL2 V 193 - G.H5 E 380 G.H5.22
Van-der-waals ICL2 V 193 - G.H5 E 380 G.H5.22
Hydrophobic TM2 P 115 2x39 G.H5 Y 381 G.H5.23
Hydrophobic TM6 R 301 6x30 G.H5 L 374 G.H5.16
Van-der-waals TM6 R 301 6x30 G.H5 L 374 G.H5.16
Hydrophobic TM7 V 372 7x56 G.H5 N 382 G.H5.24
Hydrophobic ICL2 R 192 - G.H5 M 376 G.H5.18
Van-der-waals ICL2 R 192 - G.H5 M 376 G.H5.18
Polar ICL2 S 191 - G.H5 N 377 G.H5.19
Hydrophobic TM2 P 115 2x39 G.H5 E 380 G.H5.22
Aromatic ICL2 W 190 - G.H5 F 366 G.H5.08
Hydrophobic ICL2 W 190 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 W 190 - G.H5 F 366 G.H5.08
Hydrophobic TM7 V 372 7x56 G.H5 L 383 G.H5.25
Hydrophobic TM3 V 187 3x54 G.H5 L 374 G.H5.16
Hydrophobic TM6 V 304 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 V 304 6x33 G.H5 L 383 G.H5.25
Polar TM3 R 185 3x52 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 185 3x52 G.H5 Y 381 G.H5.23
Hydrophobic TM6 H 297 6x26 G.S6 Y 350 G.S6.02
Van-der-waals ICL4 K 375 - G.H5 R 379 G.H5.21
Polar ICL4 S 373 - G.H5 N 382 G.H5.24
Hydrophobic ICL4 S 373 - G.H5 N 382 G.H5.24
Van-der-waals ICL4 S 373 - G.H5 N 382 G.H5.24
Hydrophobic TM7 V 372 7x56 G.H5 V 384 G.H5.26
Van-der-waals TM7 V 372 7x56 G.H5 V 384 G.H5.26
Ionic TM5 E 281 5x64 G.H5 K 370 G.H5.12
Polar TM5 E 281 5x64 G.H5 K 370 G.H5.12
Hydrophobic TM3 R 183 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM5 M 278 5x61 G.H5 L 383 G.H5.25
Van-der-waals TM5 M 278 5x61 G.H5 L 383 G.H5.25
Hydrophobic TM3 A 186 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 A 186 3x53 G.H5 Y 381 G.H5.23
Polar ICL2 V 193 - G.H5 N 377 G.H5.19
Hydrophobic ICL2 V 193 - G.H5 N 377 G.H5.19