5-HT5A receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

July 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

5-CT - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 R 139 3x50 G.H5 C 222 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 222 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 222 G.H5.23
Hydrophobic ICL2 M 147 34x51 G.S3 L 76 G.S3.01
Hydrophobic TM6 M 286 6x36 G.H5 L 224 G.H5.25
Van-der-waals TM6 M 286 6x36 G.H5 L 224 G.H5.25
Van-der-waals TM6 R 282 6x32 G.H5 L 224 G.H5.25
Hydrophobic TM6 V 287 6x37 G.H5 L 224 G.H5.25
Polar TM3 S 142 3x53 G.H5 N 218 G.H5.19
Hydrophobic TM3 S 142 3x53 G.H5 N 218 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 218 G.H5.19
Hydrophobic TM6 K 279 6x29 G.H5 Y 225 G.H5.26
Hydrophobic TM5 R 230 5x68 G.H5 A 216 G.H5.17
Van-der-waals TM5 R 230 5x68 G.H5 A 216 G.H5.17
Hydrophobic TM6 A 283 6x33 G.H5 L 224 G.H5.25
Ionic TM5 R 230 5x68 G.H5 D 212 G.H5.13
Polar TM5 R 230 5x68 G.H5 D 212 G.H5.13
Hydrophobic TM5 R 230 5x68 G.H5 D 212 G.H5.13
Van-der-waals TM5 R 230 5x68 G.H5 D 212 G.H5.13
Hydrophobic TM3 I 143 3x54 G.H5 L 219 G.H5.20
Hydrophobic TM3 I 143 3x54 G.H5 N 218 G.H5.19
Hydrophobic ICL2 P 146 34x50 G.H5 I 214 G.H5.15
Polar H8 N 342 8x47 G.H5 G 221 G.H5.22
Hydrophobic ICL2 M 147 34x51 G.H5 T 211 G.H5.12
Van-der-waals ICL2 M 147 34x51 G.H5 T 211 G.H5.12
Hydrophobic TM5 I 223 5x61 G.H5 L 224 G.H5.25
Van-der-waals TM5 I 223 5x61 G.H5 L 224 G.H5.25
Hydrophobic TM4 L 151 4x35 G.hns1 A 28 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.H5 T 211 G.H5.12
Hydrophobic ICL2 M 147 34x51 G.H5 I 214 G.H5.15
Van-der-waals ICL2 M 147 34x51 G.H5 I 214 G.H5.15
Hydrophobic TM5 R 230 5x68 G.H5 I 215 G.H5.16
Hydrophobic ICL2 P 146 34x50 G.H5 I 215 G.H5.16