SST5 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

June 12, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Octreotide - Agonist pubchem

PHYSIOLOGICAL LIGANDS

CST-17, SRIF-28, cortistatin-14, SRIF-14



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 V 246 6x33 G.H5 F 361 G.H5.26
Van-der-waals TM6 V 246 6x33 G.H5 F 361 G.H5.26
Hydrophobic TM6 M 249 6x36 G.H5 L 360 G.H5.25
Van-der-waals TM6 M 249 6x36 G.H5 L 360 G.H5.25
Hydrophobic TM5 A 231 5x68 G.H5 I 351 G.H5.16
Van-der-waals TM5 A 231 5x68 G.H5 I 351 G.H5.16
Polar H8 N 310 8x49 G.H5 R 356 G.H5.21
Hydrophobic H8 N 310 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 N 310 8x49 G.H5 R 356 G.H5.21
Hydrophobic ICL3 R 241 - G.H5 F 361 G.H5.26
Van-der-waals ICL3 R 241 - G.H5 F 361 G.H5.26
Hydrophobic ICL3 V 235 - G.S6 Y 327 G.S6.02
Hydrophobic TM3 R 137 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM3 A 140 3x53 G.H5 C 358 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 C 358 G.H5.23
Hydrophobic TM6 S 242 6x29 G.H5 F 361 G.H5.26
Van-der-waals TM6 S 242 6x29 G.H5 F 361 G.H5.26
Aromatic TM6 K 245 6x32 G.H5 F 361 G.H5.26
Hydrophobic TM6 K 245 6x32 G.H5 F 361 G.H5.26
Van-der-waals TM6 K 245 6x32 G.H5 F 361 G.H5.26
Ionic H8 D 309 8x48 G.h4s6 R 323 G.h4s6.12
Hydrophobic ICL3 V 235 - G.H5 D 348 G.H5.13
Van-der-waals ICL3 V 235 - G.H5 D 348 G.H5.13
Polar H8 Q 313 8x52 G.h4s6 R 323 G.h4s6.12
Van-der-waals H8 Q 313 8x52 G.h4s6 R 323 G.h4s6.12
Hydrophobic TM3 V 141 3x54 G.H5 C 358 G.H5.23
Van-der-waals TM3 V 141 3x54 G.H5 C 358 G.H5.23
Hydrophobic ICL3 V 235 - G.H5 N 344 G.H5.09