US28 - G11

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Human cytomegalovirus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

4.0 Å

REFERENCE

PUBLICATION DATE

Jan. 26, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Fractalkine - Agonist pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM4 V 141 4x39 G.HN R 24 G.HN.48
Hydrophobic TM6 I 226 6x33 G.H5 V 353 G.H5.26
Hydrophobic TM3 R 129 3x50 G.H5 L 352 G.H5.25
Van-der-waals TM3 R 129 3x50 G.H5 L 352 G.H5.25
Hydrophobic TM3 I 133 3x54 G.H5 L 352 G.H5.25
Van-der-waals TM3 I 133 3x54 G.H5 L 352 G.H5.25
Ionic TM6 H 222 6x29 G.H5 E 349 G.H5.22
Polar TM6 H 222 6x29 G.H5 E 349 G.H5.22
Hydrophobic TM6 H 222 6x29 G.H5 E 349 G.H5.22
Van-der-waals TM6 H 222 6x29 G.H5 E 349 G.H5.22
Hydrophobic TM3 A 132 3x53 G.H5 Y 350 G.H5.23
Van-der-waals TM3 A 132 3x53 G.H5 Y 350 G.H5.23
Polar TM3 D 128 3x49 G.H5 Y 350 G.H5.23
Van-der-waals TM3 D 128 3x49 G.H5 Y 350 G.H5.23
Hydrophobic TM7 V 294 7x56 G.H5 V 353 G.H5.26
Van-der-waals TM7 V 294 7x56 G.H5 V 353 G.H5.26
Polar TM3 R 129 3x50 G.H5 N 351 G.H5.24
Van-der-waals TM3 R 129 3x50 G.H5 N 351 G.H5.24
Hydrophobic ICL2 Y 138 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 S 218 5x68 G.H5 L 345 G.H5.18
Hydrophobic ICL3 S 220 - G.H5 L 347 G.H5.20
Van-der-waals ICL3 S 220 - G.H5 L 347 G.H5.20
Hydrophobic ICL3 Q 219 - G.H5 L 345 G.H5.18
Hydrophobic H8 G 295 8x47 G.H5 V 353 G.H5.26
Hydrophobic TM2 C 66 2x37 G.H5 Y 350 G.H5.23
Hydrophobic TM5 S 218 5x68 G.H5 L 347 G.H5.20
Van-der-waals TM5 S 218 5x68 G.H5 L 347 G.H5.20
Hydrophobic ICL2 Y 138 - G.H5 Y 350 G.H5.23
Hydrophobic TM4 P 140 4x38 G.HN R 28 G.HN.52
Van-der-waals TM4 P 140 4x38 G.HN R 28 G.HN.52
Hydrophobic TM5 V 215 5x65 G.H5 L 347 G.H5.20
Hydrophobic ICL3 Q 219 - G.h4s6 K 316 G.h4s6.13
Hydrophobic ICL3 Q 219 - G.H5 L 347 G.H5.20