LH receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.9 Å

REFERENCE

PUBLICATION DATE

Sept. 29, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Choriogonadotropin beta - Agonist gtoplig ,

Glycoprotein alpha - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

LH, hCG



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 I 472 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 I 472 - G.H5 F 343 G.H5.08
Hydrophobic TM6 K 570 6x36 G.H5 L 360 G.H5.25
Hydrophobic TM3 I 468 3x54 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 I 472 - G.S3 V 194 G.S3.01
Hydrophobic ICL3 L 558 - G.S6 P 328 G.S6.03
Polar H8 K 628 8x48 G.H5 R 356 G.H5.21
Van-der-waals H8 K 628 8x48 G.H5 R 356 G.H5.21
Hydrophobic ICL2 L 474 - G.S1 H 34 G.S1.02
Hydrophobic TM3 I 468 3x54 G.H5 H 354 G.H5.19
Polar TM5 V 553 5x65 G.H5 R 352 G.H5.17
Van-der-waals TM5 V 553 5x65 G.H5 R 352 G.H5.17
Hydrophobic TM6 I 567 6x33 G.H5 L 355 G.H5.20
Van-der-waals ICL2 L 474 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 L 574 6x40 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 574 6x40 G.H5 L 360 G.H5.25
Polar TM3 I 468 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM3 I 468 3x54 G.H5 Q 351 G.H5.16
Van-der-waals TM3 I 468 3x54 G.H5 Q 351 G.H5.16
Hydrophobic ICL2 I 472 - G.H5 C 346 G.H5.11
Van-der-waals ICL2 I 472 - G.H5 C 346 G.H5.11
Polar ICL2 I 472 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 I 472 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 I 472 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 I 472 - G.H5 I 350 G.H5.15
Hydrophobic TM3 I 468 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 468 3x54 G.H5 L 355 G.H5.20
Hydrophobic TM6 A 560 6x26 G.h4s6 Y 325 G.h4s6.20
Hydrophobic TM6 I 567 6x33 G.H5 L 361 G.H5.26
Van-der-waals TM6 I 567 6x33 G.H5 L 361 G.H5.26
Polar TM3 T 467 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 T 467 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM5 V 553 5x65 G.H5 L 355 G.H5.20
Van-der-waals TM5 V 553 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM6 I 567 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 I 567 6x33 G.H5 L 360 G.H5.25
Hydrophobic H8 T 627 8x47 G.H5 E 359 G.H5.24
Van-der-waals H8 T 627 8x47 G.H5 E 359 G.H5.24
Hydrophobic ICL2 I 472 - G.H5 R 347 G.H5.12
Hydrophobic TM6 K 563 6x29 G.H5 L 361 G.H5.26
Hydrophobic TM6 K 566 6x32 G.H5 L 361 G.H5.26
Van-der-waals TM6 K 566 6x32 G.H5 L 361 G.H5.26
Ionic H8 K 628 8x48 G.H5 E 359 G.H5.24
Polar H8 K 628 8x48 G.H5 E 359 G.H5.24
Van-der-waals H8 K 628 8x48 G.H5 E 359 G.H5.24
Hydrophobic ICL2 A 471 - G.H5 H 354 G.H5.19
Ionic TM6 D 564 6x30 G.H5 R 352 G.H5.17
Hydrophobic ICL2 A 471 - G.H5 Q 351 G.H5.16
Van-der-waals ICL2 A 471 - G.H5 Q 351 G.H5.16
Hydrophobic ICL2 H 473 - G.S3 V 194 G.S3.01
Polar TM3 E 463 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 E 463 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 E 463 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM2 P 394 2x39 G.H5 Y 358 G.H5.23
Polar ICL3 N 555 - G.H5 R 352 G.H5.17
Hydrophobic ICL3 N 555 - G.H5 R 352 G.H5.17
Van-der-waals ICL3 N 555 - G.H5 R 352 G.H5.17
Hydrophobic ICL3 L 558 - G.S6 Y 327 G.S6.02
Aromatic TM3 R 464 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 464 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 464 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 A 471 - G.H5 I 350 G.H5.15