EP3 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

Aug. 17, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

PGE1, PGI2, thromboxane A2, PGF, PGD2, PGE2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 I 159 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 159 3x54 G.H5 I 344 G.H5.16
Polar TM3 R 155 3x50 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 162 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 162 34x50 G.H5 I 343 G.H5.15
Polar TM6 Q 283 6x36 G.H5 G 352 G.H5.24
Polar TM3 E 154 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 154 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 E 154 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 159 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 159 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 163 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 R 155 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 155 3x50 G.H5 L 353 G.H5.25
Polar ICL2 Y 165 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 165 34x53 G.H5 C 351 G.H5.23
Van-der-waals TM6 Q 283 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 162 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 162 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 165 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 165 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL1 K 85 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 S 167 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 167 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 S 167 34x55 G.HN E 28 G.HN.52
Hydrophobic TM3 A 158 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 256 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM2 F 88 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 88 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 F 88 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 F 88 2x39 G.H5 G 352 G.H5.24
Polar TM5 R 259 5x68 G.H5 T 340 G.H5.12
Polar TM3 R 155 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 162 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 162 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 276 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 276 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 280 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 280 6x33 G.H5 L 353 G.H5.25
Polar TM2 S 87 2x38 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 87 2x38 G.H5 D 350 G.H5.22