GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Sept. 11, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

cis-epoxysuccinic acid - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

succinic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 I 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 123 3x53 G.H5 N 347 G.H5.19
Polar TM5 R 217 5x68 G.H5 D 337 G.H5.09
Polar ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 227 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 F 128 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 127 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 128 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 128 - G.S3 L 194 G.S3.01
Hydrophobic TM6 P 230 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Polar TM5 R 217 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 217 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 K 229 6x32 G.H5 F 354 G.H5.26
Polar ICL2 P 127 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 127 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 127 - G.H5 N 347 G.H5.19
Hydrophobic TM3 I 123 3x53 G.H5 C 351 G.H5.23
Polar ICL3 L 225 - G.H5 K 345 G.H5.17
Hydrophobic TM5 R 217 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 227 - G.H5 K 345 G.H5.17
Hydrophobic TM6 L 233 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL3 A 224 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 A 224 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 F 213 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 128 - G.H5 I 343 G.H5.15
Hydrophobic TM6 P 230 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 227 - G.H5 F 354 G.H5.26
Ionic H8 H 301 8x49 G.H5 D 350 G.H5.22
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 214 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 P 230 6x33 G.H5 L 353 G.H5.25