P2RY10 - G13

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8KGG

RESOLUTION

3.1 Å

REFERENCE

10.1016/J.CHEMBIOL.2024.08.005

PUBLICATION DATE

July 31, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid - Agonist

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, LPA, 1-O-Oleoyl-D-glycerol 3-phosphoric acid, LYSOPHOSPHATIDIC ACID



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 Q 130 3x49 G.H5 L 227 G.H5.23
Hydrophobic TM3 L 135 3x54 G.H5 L 224 G.H5.20
Van-der-waals TM3 L 135 3x54 G.H5 L 224 G.H5.20
Hydrophobic TM2 A 69 2x39 G.H5 L 227 G.H5.23
Van-der-waals TM2 A 69 2x39 G.H5 L 227 G.H5.23
Polar TM3 F 134 3x53 G.H5 N 223 G.H5.19
Hydrophobic TM3 F 134 3x53 G.H5 N 223 G.H5.19
Van-der-waals TM3 F 134 3x53 G.H5 N 223 G.H5.19
Hydrophobic ICL2 F 139 - G.S3 V 79 G.S3.01
Hydrophobic ICL2 D 143 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 L 135 3x54 G.H5 L 220 G.H5.16
Van-der-waals TM3 L 135 3x54 G.H5 L 220 G.H5.16
Hydrophobic TM3 L 135 3x54 G.H5 N 223 G.H5.19
Hydrophobic ICL2 F 139 - G.H5 K 216 G.H5.12
Hydrophobic ICL2 R 142 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 R 142 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 P 138 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 219 G.H5.15
Hydrophobic ICL2 F 139 - G.S1 V 34 G.S1.02
Hydrophobic TM6 V 245 6x38 G.H5 L 229 G.H5.25
Polar C-term S 310 - G.H5 Q 230 G.H5.26
Polar TM6 K 240 6x33 G.H5 Q 230 G.H5.26
Hydrophobic TM6 K 240 6x33 G.H5 Q 230 G.H5.26
Polar ICL2 R 142 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 142 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 142 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 139 - G.S3 F 81 G.S3.03
Hydrophobic TM6 R 238 6x31 G.H5 L 220 G.H5.16
Van-der-waals TM6 R 238 6x31 G.H5 L 220 G.H5.16
Hydrophobic ICL1 K 66 - G.H5 Q 226 G.H5.22
Hydrophobic TM3 R 131 3x50 G.H5 L 229 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 229 G.H5.25
Hydrophobic TM6 M 244 6x37 G.H5 Q 230 G.H5.26
Van-der-waals TM6 M 244 6x37 G.H5 Q 230 G.H5.26
Hydrophobic ICL3 L 225 - G.H5 L 224 G.H5.20
Van-der-waals ICL3 L 225 - G.H5 L 224 G.H5.20
Ionic TM6 R 238 6x31 G.H5 D 217 G.H5.13
Polar TM6 R 238 6x31 G.H5 D 217 G.H5.13
Van-der-waals TM6 R 238 6x31 G.H5 D 217 G.H5.13
Hydrophobic ICL2 F 139 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 F 139 - G.H5 I 219 G.H5.15
Aromatic ICL2 F 139 - G.H5 F 212 G.H5.08
Hydrophobic ICL2 F 139 - G.H5 F 212 G.H5.08
Van-der-waals ICL2 F 139 - G.H5 F 212 G.H5.08
Hydrophobic TM3 F 134 3x53 G.H5 L 227 G.H5.23
Van-der-waals TM3 F 134 3x53 G.H5 L 227 G.H5.23
Polar TM6 R 238 6x31 G.H5 H 221 G.H5.17
Hydrophobic TM1 F 62 1x60 G.H5 M 228 G.H5.24
Hydrophobic ICL2 P 138 - G.H5 K 216 G.H5.12
Hydrophobic ICL3 M 230 - G.H5 D 217 G.H5.13
Hydrophobic C-term A 309 - G.H5 Q 230 G.H5.26
Polar C-term E 311 - G.H5 M 228 G.H5.24
Hydrophobic C-term E 311 - G.H5 M 228 G.H5.24
Van-der-waals C-term E 311 - G.H5 M 228 G.H5.24
Hydrophobic TM6 R 238 6x31 G.H5 L 224 G.H5.20
Hydrophobic TM6 E 237 6x30 G.H5 Q 230 G.H5.26
Van-der-waals TM6 E 237 6x30 G.H5 Q 230 G.H5.26
Hydrophobic ICL2 F 139 - G.H5 V 215 G.H5.11
Polar ICL2 R 142 - G.S1 L 33 G.S1.01
Hydrophobic ICL3 F 232 - G.h4s6 P 194 G.h4s6.20
Van-der-waals ICL3 F 232 - G.h4s6 P 194 G.h4s6.20
Polar TM3 R 131 3x50 G.H5 M 228 G.H5.24
Hydrophobic ICL3 F 232 - G.h4s6 Q 190 G.h4s6.11
Van-der-waals ICL3 F 232 - G.h4s6 Q 190 G.h4s6.11
Polar ICL1 N 67 - G.H5 Q 226 G.H5.22
Hydrophobic ICL1 N 67 - G.H5 Q 226 G.H5.22
Van-der-waals ICL1 N 67 - G.H5 Q 226 G.H5.22
Hydrophobic TM6 A 241 6x34 G.H5 L 224 G.H5.20
Hydrophobic TM6 M 244 6x37 G.H5 L 229 G.H5.25
Van-der-waals TM6 M 244 6x37 G.H5 L 229 G.H5.25
Ionic ICL1 K 66 - G.H5 D 222 G.H5.18
Polar ICL1 K 66 - G.H5 D 222 G.H5.18
Van-der-waals ICL1 K 66 - G.H5 D 222 G.H5.18
Hydrophobic TM6 A 241 6x34 G.H5 L 229 G.H5.25
Van-der-waals TM6 A 241 6x34 G.H5 L 229 G.H5.25
Van-der-waals C-term E 311 - G.H5 K 225 G.H5.21
Hydrophobic TM3 L 135 3x54 G.H5 L 229 G.H5.25
Hydrophobic C-term F 312 - G.H5 M 228 G.H5.24
Hydrophobic ICL3 A 231 - G.S6 Y 196 G.S6.02
Hydrophobic ICL3 F 232 - G.h4s6 Q 191 G.h4s6.12
Van-der-waals ICL3 F 232 - G.h4s6 Q 191 G.h4s6.12
Polar TM3 R 131 3x50 G.H5 L 227 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 L 227 G.H5.23