Refined structure (8GUT) of Gi1 - CB2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 211 from structure (59.6%), 143 from model (40.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure AF2
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 290 from structure (88.1%), 39 from model (11.9%)
Residue sidechains - 289 from structure (87.8%), 40 from model (12.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 E - AF2 AF2
N-term 4 C - AF2 AF2
N-term 5 W - AF2 AF2
N-term 6 V - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 E - AF2 AF2
N-term 9 I - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 K - AF2 AF2
N-term 15 D - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 D - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 N - AF2 AF2
N-term 21 P - Structure Structure
N-term 22 M - Structure Structure
N-term 23 K - Structure Structure
N-term 24 D - Structure Structure
N-term 25 Y - Structure Structure
N-term 26 M - Structure Structure
N-term 27 I - Structure Structure
N-term 28 L - Structure Structure
TM1 29 S 1.28x28 Structure Structure
TM1 30 G 1.29x29 Structure Structure
TM1 31 P 1.30x30 Structure Structure
TM1 32 Q 1.31x31 Structure Structure
TM1 33 K 1.32x32 Structure Structure
TM1 34 T 1.33x33 Structure Structure
TM1 35 A 1.34x34 Structure Structure
TM1 36 V 1.35x35 Structure Structure
TM1 37 A 1.36x36 Structure Structure
TM1 38 V 1.37x37 Structure Structure
TM1 39 L 1.38x38 Structure Structure
TM1 40 C 1.39x39 Structure Structure
TM1 41 T 1.40x40 Structure Structure
TM1 42 L 1.41x41 Structure Structure
TM1 43 L 1.42x42 Structure Structure
TM1 44 G 1.43x43 Structure Structure
TM1 45 L 1.44x44 Structure Structure
TM1 46 L 1.45x45 Structure Structure
TM1 47 S 1.46x46 Structure Structure
TM1 48 A 1.47x47 Structure Structure
TM1 49 L 1.48x48 Structure Structure
TM1 50 E 1.49x49 Structure Structure
TM1 51 N 1.50x50 Structure Structure
TM1 52 V 1.51x51 Structure Structure
TM1 53 A 1.52x52 Structure Structure
TM1 54 V 1.53x53 Structure Structure
TM1 55 L 1.54x54 Structure Structure
TM1 56 Y 1.55x55 Structure Structure
TM1 57 L 1.56x56 Structure Structure
TM1 58 I 1.57x57 Structure Structure
TM1 59 L 1.58x58 Structure Structure
TM1 60 S 1.59x59 Structure Structure
TM1 61 S 1.60x60 Structure Structure
ICL1 62 H 12.48x48 Structure Structure
ICL1 63 Q 12.49x49 Structure Structure
ICL1 64 L 12.50x50 Structure Structure
ICL1 65 R 12.51x51 Structure Structure
ICL1 66 R - Structure Structure
TM2 67 K 2.37x37 Structure Structure
TM2 68 P 2.38x38 Structure Structure
TM2 69 S 2.39x39 Structure Structure
TM2 70 Y 2.40x40 Structure Structure
TM2 71 L 2.41x41 Structure Structure
TM2 72 F 2.42x42 Structure Structure
TM2 73 I 2.43x43 Structure Structure
TM2 74 G 2.44x44 Structure Structure
TM2 75 S 2.45x45 Structure Structure
TM2 76 L 2.46x46 Structure Structure
TM2 77 A 2.47x47 Structure Structure
TM2 78 G 2.48x48 Structure Structure
TM2 79 A 2.49x49 Structure Structure
TM2 80 D 2.50x50 Structure Structure
TM2 81 F 2.51x51 Structure Structure
TM2 82 L 2.52x52 Structure Structure
TM2 83 A 2.53x53 Structure Structure
TM2 84 S 2.54x54 Structure Structure
TM2 85 V 2.55x55 Structure Structure
TM2 86 V 2.56x56 Structure Structure
TM2 87 F 2.57x57 Structure Structure
TM2 88 A 2.58x58 Structure Structure
TM2 89 C 2.59x59 Structure Structure
TM2 90 S 2.60x60 Structure Structure
TM2 91 F 2.61x61 Structure Structure
TM2 92 V 2.62x62 Structure Structure
TM2 93 N 2.63x63 Structure Structure
TM2 94 F 2.64x64 Structure Structure
TM2 95 H 2.65x65 Structure Structure
TM2 96 V 2.66x66 Structure Structure
ECL1 97 F - Structure Structure
ECL1 98 H - Structure Structure
ECL1 99 G - Structure Structure
ECL1 100 V - Structure Structure
ECL1 101 D - Structure Structure
TM3 102 S 3.21x21 Structure Structure
TM3 103 K 3.22x22 Structure Structure
TM3 104 A 3.23x23 Structure Structure
TM3 105 V 3.24x24 Structure Structure
TM3 106 F 3.25x25 Structure Structure
TM3 107 L 3.26x26 Structure Structure
TM3 108 L 3.27x27 Structure Structure
TM3 109 K 3.28x28 Structure Structure
TM3 110 I 3.29x29 Structure Structure
TM3 111 G 3.30x30 Structure Structure
TM3 112 S 3.31x31 Structure Structure
TM3 113 V 3.32x32 Structure Structure
TM3 114 T 3.33x33 Structure Structure
TM3 115 M 3.34x34 Structure Structure
TM3 116 T 3.35x35 Structure Structure
TM3 117 F 3.36x36 Structure Structure
TM3 118 T 3.37x37 Structure Structure
TM3 119 A 3.38x38 Structure Structure
TM3 120 S 3.39x39 Structure Structure
TM3 121 V 3.40x40 Structure Structure
TM3 122 G 3.41x41 Structure Structure
TM3 123 S 3.42x42 Structure Structure
TM3 124 L 3.43x43 Structure Structure
TM3 125 L 3.44x44 Structure Structure
TM3 126 L 3.45x45 Structure Structure
TM3 127 T 3.46x46 Structure Structure
TM3 128 A 3.47x47 Structure Structure
TM3 129 I 3.48x48 Structure Structure
TM3 130 D 3.49x49 Structure Structure
TM3 131 R 3.50x50 Structure Structure
TM3 132 Y 3.51x51 Structure Structure
TM3 133 L 3.52x52 Structure Structure
TM3 134 C 3.53x53 Structure Structure
TM3 135 L 3.54x54 Structure Structure
TM3 136 R 3.55x55 Structure Structure
TM3 137 Y 3.56x56 Structure Structure
ICL2 138 P 34.50x50 Structure Structure
ICL2 139 P 34.51x51 Structure Structure
ICL2 140 S 34.52x52 Structure Structure
ICL2 141 Y 34.53x53 Structure Structure
ICL2 142 K 34.54x54 Structure Structure
ICL2 143 A 34.55x55 Structure Structure
ICL2 144 L 34.56x56 Structure Structure
ICL2 145 L 34.57x57 Structure Structure
TM4 146 T 4.38x38 Structure Structure
TM4 147 R 4.39x39 Structure Structure
TM4 148 G 4.40x40 Structure Structure
TM4 149 R 4.41x41 Structure Structure
TM4 150 A 4.42x42 Structure Structure
TM4 151 L 4.43x43 Structure Structure
TM4 152 V 4.44x44 Structure Structure
TM4 153 T 4.45x45 Structure Structure
TM4 154 L 4.46x46 Structure Structure
TM4 155 G 4.47x47 Structure Structure
TM4 156 I 4.48x48 Structure Structure
TM4 157 M 4.49x49 Structure Structure
TM4 158 W 4.50x50 Structure Structure
TM4 159 V 4.51x51 Structure Structure
TM4 160 L 4.52x52 Structure Structure
TM4 161 S 4.53x53 Structure Structure
TM4 162 A 4.54x54 Structure Structure
TM4 163 L 4.55x55 Structure Structure
TM4 164 V 4.56x56 Structure Structure
TM4 165 S 4.57x57 Structure Structure
TM4 166 Y 4.58x58 Structure Structure
TM4 167 L 4.59x59 Structure Structure
TM4 168 P 4.60x60 Structure Structure
TM4 169 L 4.61x61 Structure Structure
TM4 170 M 4.62x62 Structure Structure
TM4 171 G 4.63x63 Structure Structure
ECL2 172 W - Structure Structure
ECL2 173 T - Structure Structure
ECL2 174 C - Structure Structure
ECL2 175 C - Structure Structure
ECL2 176 P - Structure Structure
ECL2 177 R - Structure AF2
ECL2 178 P - Structure Structure
ECL2 179 C - Structure Structure
ECL2 180 S - Structure Structure
ECL2 181 E - Structure Structure
ECL2 182 L - Structure Structure
ECL2 183 F - Structure Structure
ECL2 184 P - Structure Structure
ECL2 185 L - Structure Structure
ECL2 186 I - Structure Structure
TM5 187 P 5.36x36 Structure Structure
TM5 188 N 5.37x37 Structure Structure
TM5 189 D 5.38x38 Structure Structure
TM5 190 Y 5.39x39 Structure Structure
TM5 191 L 5.40x40 Structure Structure
TM5 192 L 5.41x41 Structure Structure
TM5 193 S 5.42x42 Structure Structure
TM5 194 W 5.43x43 Structure Structure
TM5 195 L 5.44x44 Structure Structure
TM5 196 L 5.45x45 Structure Structure
TM5 197 F 5.46x46 Structure Structure
TM5 198 I 5.47x47 Structure Structure
TM5 199 A 5.48x48 Structure Structure
TM5 200 F 5.49x49 Structure Structure
TM5 201 L 5.50x50 Structure Structure
TM5 202 F 5.51x51 Structure Structure
TM5 203 S 5.52x52 Structure Structure
TM5 204 G 5.53x53 Structure Structure
TM5 205 I 5.54x54 Structure Structure
TM5 206 I 5.55x55 Structure Structure
TM5 207 Y 5.56x56 Structure Structure
TM5 208 T 5.57x57 Structure Structure
TM5 209 Y 5.58x58 Structure Structure
TM5 210 G 5.59x59 Structure Structure
TM5 211 H 5.60x60 Structure Structure
TM5 212 V 5.61x61 Structure Structure
TM5 213 L 5.62x62 Structure Structure
TM5 214 W 5.63x63 Structure Structure
TM5 215 K 5.64x64 Structure Structure
TM5 216 A 5.65x65 Structure Structure
TM5 217 H 5.66x66 Structure Structure
TM5 218 Q 5.67x67 Structure Structure
TM5 219 H 5.68x68 Structure Structure
TM5 220 V 5.69x69 Structure Structure
TM5 221 A 5.70x70 Structure Structure
TM5 222 S 5.71x71 Structure Structure
TM5 223 L 5.72x72 Structure Structure
TM5 224 S 5.73x73 Structure Structure
TM5 225 G 5.74x74 Structure Structure
ICL3 226 H - Structure Structure
ICL3 227 Q - Structure Structure
ICL3 228 D - AF2 AF2
ICL3 229 R - AF2 AF2
ICL3 230 Q - AF2 AF2
ICL3 231 V - AF2 AF2
ICL3 232 P - AF2 AF2
ICL3 233 G - AF2 AF2
ICL3 234 M - AF2 AF2
ICL3 235 A - AF2 AF2
ICL3 236 R - AF2 AF2
ICL3 237 M - Structure Structure
TM6 238 R 6.28x28 Structure Structure
TM6 239 L 6.29x29 Structure Structure
TM6 240 D 6.30x30 Structure Structure
TM6 241 V 6.31x31 Structure Structure
TM6 242 R 6.32x32 Structure Structure
TM6 243 L 6.33x33 Structure Structure
TM6 244 A 6.34x34 Structure Structure
TM6 245 K 6.35x35 Structure Structure
TM6 246 T 6.36x36 Structure Structure
TM6 247 L 6.37x37 Structure Structure
TM6 248 G 6.38x38 Structure Structure
TM6 249 L 6.39x39 Structure Structure
TM6 250 V 6.40x40 Structure Structure
TM6 251 L 6.41x41 Structure Structure
TM6 252 A 6.42x42 Structure Structure
TM6 253 V 6.43x43 Structure Structure
TM6 254 L 6.44x44 Structure Structure
TM6 255 L 6.45x45 Structure Structure
TM6 256 I 6.46x46 Structure Structure
TM6 257 C 6.47x47 Structure Structure
TM6 258 W 6.48x48 Structure Structure
TM6 259 F 6.49x49 Structure Structure
TM6 260 P 6.50x50 Structure Structure
TM6 261 V 6.51x51 Structure Structure
TM6 262 L 6.52x52 Structure Structure
TM6 263 A 6.53x53 Structure Structure
TM6 264 L 6.54x54 Structure Structure
TM6 265 M 6.55x55 Structure Structure
TM6 266 A 6.56x56 Structure Structure
TM6 267 H 6.57x57 Structure Structure
TM6 268 S 6.58x58 Structure Structure
TM6 269 L 6.59x59 Structure Structure
TM6 270 A 6.60x60 Structure Structure
TM6 271 T 6.61x61 Structure Structure
ECL3 272 T - Structure Structure
ECL3 273 L - Structure Structure
TM7 274 S 7.28x27 Structure Structure
TM7 275 D 7.29x28 Structure Structure
TM7 276 Q 7.30x29 Structure Structure
TM7 277 V 7.31x30 Structure Structure
TM7 278 K 7.32x31 Structure Structure
TM7 279 K 7.33x32 Structure Structure
TM7 280 A 7.34x33 Structure Structure
TM7 281 F 7.35x34 Structure Structure
TM7 282 A 7.36x35 Structure Structure
TM7 283 F 7.37x36 Structure Structure
TM7 284 C 7.38x37 Structure Structure
TM7 285 S 7.39x38 Structure Structure
TM7 286 M 7.40x39 Structure Structure
TM7 287 L 7.41x40 Structure Structure
TM7 288 C 7.42x41 Structure Structure
TM7 289 L 7.43x42 Structure Structure
TM7 290 I 7.44x43 Structure Structure
TM7 291 N 7.45x45 Structure Structure
TM7 292 S 7.46x46 Structure Structure
TM7 293 M 7.47x47 Structure Structure
TM7 294 V 7.48x48 Structure Structure
TM7 295 N 7.49x49 Structure Structure
TM7 296 P 7.50x50 Structure Structure
TM7 297 V 7.51x51 Structure Structure
TM7 298 I 7.52x52 Structure Structure
TM7 299 Y 7.53x53 Structure Structure
TM7 300 A 7.54x54 Structure Structure
TM7 301 L 7.55x55 Structure Structure
TM7 302 R 7.56x56 Structure Structure
H8 303 S 8.47x47 Structure Structure
H8 304 G 8.48x48 Structure Structure
H8 305 E 8.49x49 Structure Structure
H8 306 I 8.50x50 Structure Structure
H8 307 R 8.51x51 Structure Structure
H8 308 S 8.52x52 Structure Structure
H8 309 S 8.53x53 Structure Structure
H8 310 A 8.54x54 Structure Structure
H8 311 H 8.55x55 Structure Structure
H8 312 H 8.56x56 Structure Structure
H8 313 C 8.57x57 Structure Structure
H8 314 L 8.58x58 Structure Structure
H8 315 A 8.59x59 Structure Structure
H8 316 H 8.60x60 Structure Structure
H8 317 W 8.61x61 Structure Structure
H8 318 K 8.62x62 Structure Structure
H8 319 K 8.63x63 Structure Structure
C-term 320 C - AF2 AF2
C-term 321 V - AF2 AF2
C-term 322 R - AF2 AF2
C-term 323 G - AF2 AF2
C-term 324 L - AF2 AF2
C-term 325 G - AF2 AF2
C-term 326 S - AF2 AF2
C-term 327 E - AF2 AF2
C-term 328 A - AF2 AF2
C-term 329 K - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 D 130 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 130 3x49 G.H5 C 351 G.H5.23
Polar ICL2 S 140 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 140 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 140 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 138 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 138 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 223 5x72 G.S6 Y 320 G.S6.02
Ionic ICL3 R 229 - G.H4 E 297 G.H4.04
Polar ICL3 R 229 - G.H4 E 297 G.H4.04
Hydrophobic ICL3 R 229 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 R 229 - G.H4 E 297 G.H4.04
Polar ICL3 H 226 - G.H5 Q 333 G.H5.05
Hydrophobic ICL3 H 226 - G.H5 Q 333 G.H5.05
Van-der-waals ICL3 H 226 - G.H5 Q 333 G.H5.05
Polar TM2 S 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 69 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 247 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 141 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 141 34x53 G.H5 N 347 G.H5.19
Ionic TM5 H 219 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 219 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 219 5x68 G.H5 D 341 G.H5.13
Aromatic TM6 R 242 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 242 6x32 G.H5 F 354 G.H5.26
Polar H8 S 303 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 303 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 303 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 H 219 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 239 6x29 G.H5 F 354 G.H5.26
Polar H8 G 304 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL3 V 231 - G.H4 Q 304 G.H4.12
Hydrophobic TM6 L 243 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 243 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x33 G.H5 L 353 G.H5.25
Polar TM3 C 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 139 34x51 G.H5 I 343 G.H5.15
Polar ICL2 P 138 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 138 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 143 34x55 G.HN E 28 G.HN.52
Polar TM2 S 69 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 69 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Polar TM2 K 67 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 K 67 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 67 2x37 G.H5 D 350 G.H5.22
Polar ICL3 R 236 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 R 236 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 R 236 - G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 L 135 3x54 G.H5 L 348 G.H5.20
Polar ICL2 K 142 34x54 G.H5 N 347 G.H5.19
Ionic ICL2 K 142 34x54 G.H5 D 350 G.H5.22
Polar ICL2 K 142 34x54 G.H5 D 350 G.H5.22
Hydrophobic ICL2 K 142 34x54 G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 142 34x54 G.H5 D 350 G.H5.22
Polar ICL2 A 143 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 143 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 143 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 223 5x72 G.H5 A 338 G.H5.10
Polar TM3 C 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 134 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 134 3x53 G.H5 C 351 G.H5.23
Polar ICL3 H 226 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 H 226 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 H 226 - G.H5 F 334 G.H5.06
Hydrophobic TM6 L 239 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 143 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 H 219 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM3 L 135 3x54 G.H5 I 344 G.H5.16
Ionic ICL3 H 226 - G.H5 D 337 G.H5.09
Polar ICL3 H 226 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 H 226 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 H 226 - G.H5 D 337 G.H5.09
Polar TM2 Y 70 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 Y 70 2x40 G.H5 G 352 G.H5.24
Polar TM5 S 222 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 S 222 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM6 L 239 6x29 G.H5 I 344 G.H5.16
Hydrophobic TM6 T 246 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 246 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL3 M 234 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 M 234 - G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 S 303 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 243 6x33 G.H5 L 348 G.H5.20
Ionic ICL3 R 236 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 144 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 144 34x56 G.hns1 R 32 G.hns1.03
Polar ICL3 R 236 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 Y 70 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 223 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 L 223 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM3 C 134 3x53 G.H5 L 348 G.H5.20
Hydrophobic ICL3 M 234 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 138 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 L 223 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 139 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 P 139 34x51 G.S3 L 194 G.S3.01