Refined structure (7VV5) of Gi1 - MRGPRX2

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 226 from structure (63.8%), 128 from model (36.2%)
Residue sidechains - 224 from structure (63.3%), 130 from model (36.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 268 from structure (90.8%), 27 from model (9.2%)
Residue sidechains - 268 from structure (90.8%), 27 from model (9.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 W - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 T - AF2 AF2
N-term 15 V - AF2 AF2
N-term 16 N - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 D - AF2 AF2
N-term 20 Q - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 L - Structure Structure
N-term 23 L - Structure Structure
N-term 24 L - Structure Structure
N-term 25 L - Structure Structure
N-term 26 C - Structure Structure
N-term 27 G - Structure Structure
N-term 28 K - Structure Structure
N-term 29 E - Structure Structure
TM1 30 T 1.32x32 Structure Structure
TM1 31 L 1.33x33 Structure Structure
TM1 32 I 1.34x34 Structure Structure
TM1 33 P 1.35x35 Structure Structure
TM1 34 V 1.36x36 Structure Structure
TM1 35 F 1.37x37 Structure Structure
TM1 36 L 1.38x38 Structure Structure
TM1 37 I 1.39x39 Structure Structure
TM1 38 L 1.40x40 Structure Structure
TM1 39 F 1.41x41 Structure Structure
TM1 40 I 1.42x42 Structure Structure
TM1 41 A 1.43x43 Structure Structure
TM1 42 L 1.44x44 Structure Structure
TM1 43 V 1.45x45 Structure Structure
TM1 44 G 1.46x46 Structure Structure
TM1 45 L 1.47x47 Structure Structure
TM1 46 V 1.48x48 Structure Structure
TM1 47 G 1.49x49 Structure Structure
TM1 48 N 1.50x50 Structure Structure
TM1 49 G 1.51x51 Structure Structure
TM1 50 F 1.52x52 Structure Structure
TM1 51 V 1.53x53 Structure Structure
TM1 52 L 1.54x54 Structure Structure
TM1 53 W 1.55x55 Structure Structure
TM1 54 L 1.56x56 Structure Structure
TM1 55 L 1.57x57 Structure Structure
TM1 56 G 1.58x58 Structure Structure
TM1 57 F 1.59x59 Structure Structure
TM1 58 R 1.60x60 Structure Structure
TM1 59 M 1.61x61 Structure Structure
ICL1 60 R - Structure Structure
ICL1 61 R - Structure Structure
TM2 62 N 2.37x37 Structure Structure
TM2 63 A 2.38x38 Structure Structure
TM2 64 F 2.39x39 Structure Structure
TM2 65 S 2.40x40 Structure Structure
TM2 66 V 2.41x41 Structure Structure
TM2 67 Y 2.42x42 Structure Structure
TM2 68 V 2.43x43 Structure Structure
TM2 69 L 2.44x44 Structure Structure
TM2 70 S 2.45x45 Structure Structure
TM2 71 L 2.46x46 Structure Structure
TM2 72 A 2.47x47 Structure Structure
TM2 73 G 2.48x48 Structure Structure
TM2 74 A 2.49x49 Structure Structure
TM2 75 D 2.50x50 Structure Structure
TM2 76 F 2.51x51 Structure Structure
TM2 77 L 2.52x52 Structure Structure
TM2 78 F 2.53x53 Structure Structure
TM2 79 L 2.54x54 Structure Structure
TM2 80 C 2.55x55 Structure Structure
TM2 81 F 2.56x56 Structure Structure
TM2 82 Q 2.57x57 Structure Structure
TM2 83 I 2.58x58 Structure Structure
TM2 84 I 2.59x59 Structure Structure
TM2 85 N 2.60x60 Structure Structure
TM2 86 C 2.61x61 Structure Structure
TM2 87 L 2.62x62 Structure Structure
TM2 88 V 2.63x63 Structure Structure
TM2 89 Y 2.64x64 Structure Structure
TM2 90 L 2.65x65 Structure Structure
TM2 91 S 2.66x66 Structure Structure
TM2 92 N 2.67x67 Structure Structure
TM2 93 F 2.68x68 Structure Structure
TM2 94 F 2.69x69 Structure Structure
TM2 95 C 2.70x70 Structure Structure
TM2 96 S 2.71x71 Structure Structure
ECL1 97 I - Structure Structure
ECL1 98 S - Structure Structure
ECL1 99 I - Structure Structure
ECL1 100 N - Structure Structure
ECL1 101 F - Structure Structure
TM3 102 P 3.25x25 Structure Structure
TM3 103 S 3.26x26 Structure Structure
TM3 104 F 3.27x27 Structure Structure
TM3 105 F 3.28x28 Structure Structure
TM3 106 T 3.29x29 Structure Structure
TM3 107 T 3.30x30 Structure Structure
TM3 108 V 3.31x31 Structure Structure
TM3 109 M 3.32x32 Structure Structure
TM3 110 T 3.33x33 Structure Structure
TM3 111 C 3.34x34 Structure Structure
TM3 112 A 3.35x35 Structure Structure
TM3 113 Y 3.36x36 Structure Structure
TM3 114 L 3.37x37 Structure Structure
TM3 115 A 3.38x38 Structure Structure
TM3 116 G 3.39x39 Structure Structure
TM3 117 L 3.40x40 Structure Structure
TM3 118 S 3.41x41 Structure Structure
TM3 119 M 3.42x42 Structure Structure
TM3 120 L 3.43x43 Structure Structure
TM3 121 S 3.44x44 Structure Structure
TM3 122 T 3.45x45 Structure Structure
TM3 123 V 3.46x46 Structure Structure
TM3 124 S 3.47x47 Structure Structure
TM3 125 T 3.48x48 Structure Structure
TM3 126 E 3.49x49 Structure Structure
TM3 127 R 3.50x50 Structure Structure
TM3 128 C 3.51x51 Structure Structure
TM3 129 L 3.52x52 Structure Structure
TM3 130 S 3.53x53 Structure Structure
TM3 131 V 3.54x54 Structure Structure
TM3 132 L 3.55x55 Structure Structure
TM3 133 W 3.56x56 Structure Structure
ICL2 134 P 34.50x50 Structure Structure
ICL2 135 I 34.51x51 Structure Structure
ICL2 136 W 34.52x52 Structure Structure
ICL2 137 Y 34.53x53 Structure Structure
ICL2 138 R 34.54x54 Structure Structure
ICL2 139 C 34.55x55 Structure Structure
ICL2 140 R 34.56x56 Structure Structure
ICL2 141 R 34.57x57 Structure Structure
TM4 142 P 4.38x38 Structure Structure
TM4 143 R 4.39x39 Structure Structure
TM4 144 H 4.40x40 Structure Structure
TM4 145 L 4.41x41 Structure Structure
TM4 146 S 4.42x42 Structure Structure
TM4 147 A 4.43x43 Structure Structure
TM4 148 V 4.44x44 Structure Structure
TM4 149 V 4.45x45 Structure Structure
TM4 150 C 4.46x46 Structure Structure
TM4 151 V 4.47x47 Structure Structure
TM4 152 L 4.48x48 Structure Structure
TM4 153 L 4.49x49 Structure Structure
TM4 154 W 4.50x50 Structure Structure
TM4 155 A 4.51x51 Structure Structure
TM4 156 L 4.52x52 Structure Structure
TM4 157 S 4.53x53 Structure Structure
TM4 158 L 4.54x54 Structure Structure
TM4 159 L 4.55x55 Structure Structure
TM4 160 L 4.56x56 Structure Structure
TM4 161 S 4.57x57 Structure Structure
TM4 162 I 4.58x58 Structure Structure
TM4 163 L 4.59x59 Structure Structure
TM4 164 E 4.60x60 Structure Structure
TM4 165 G 4.61x61 Structure Structure
TM4 166 K 4.62x62 Structure Structure
TM4 167 F 4.63x63 Structure Structure
TM4 168 C 4.64x64 Structure Structure
ECL2 169 G - Structure Structure
ECL2 170 F - Structure Structure
ECL2 171 L - Structure Structure
ECL2 172 F - Structure Structure
ECL2 173 S - Structure Structure
ECL2 174 D - Structure Structure
ECL2 175 G - Structure Structure
TM5 176 D 5.32x32 Structure Structure
TM5 177 S 5.33x33 Structure Structure
TM5 178 G 5.34x34 Structure Structure
TM5 179 W 5.35x35 Structure Structure
TM5 180 C 5.36x36 Structure Structure
TM5 181 Q 5.37x37 Structure Structure
TM5 182 T 5.38x38 Structure Structure
TM5 183 F 5.39x39 Structure Structure
TM5 184 D 5.40x40 Structure Structure
TM5 185 F 5.41x41 Structure Structure
TM5 186 I 5.42x42 Structure Structure
TM5 187 T 5.43x43 Structure Structure
TM5 188 A 5.44x44 Structure Structure
TM5 189 A 5.45x45 Structure Structure
TM5 190 W 5.46x46 Structure Structure
TM5 191 L 5.47x47 Structure Structure
TM5 192 I 5.48x48 Structure Structure
TM5 193 F 5.49x49 Structure Structure
TM5 194 L 5.50x50 Structure Structure
TM5 195 F 5.51x51 Structure Structure
TM5 196 M 5.52x52 Structure Structure
TM5 197 V 5.53x53 Structure Structure
TM5 198 L 5.54x54 Structure Structure
TM5 199 C 5.55x55 Structure Structure
TM5 200 G 5.56x56 Structure Structure
TM5 201 S 5.57x57 Structure Structure
TM5 202 S 5.58x58 Structure Structure
TM5 203 L 5.59x59 Structure Structure
TM5 204 A 5.60x60 Structure Structure
TM5 205 L 5.61x61 Structure Structure
TM5 206 L 5.62x62 Structure Structure
TM5 207 V 5.63x63 Structure Structure
TM5 208 R 5.64x64 Structure Structure
TM5 209 I 5.65x65 Structure Structure
TM5 210 L 5.66x66 Structure Structure
TM5 211 C 5.67x67 Structure Structure
TM5 212 G 5.68x68 Structure Structure
ICL3 213 S - Structure Structure
ICL3 214 R - Structure Structure
ICL3 215 G - Structure Structure
ICL3 216 L - Structure Structure
TM6 217 P 6.29x29 Structure Structure
TM6 218 L 6.30x30 Structure Structure
TM6 219 T 6.31x31 Structure Structure
TM6 220 R 6.32x32 Structure Structure
TM6 221 L 6.33x33 Structure Structure
TM6 222 Y 6.34x34 Structure Structure
TM6 223 L 6.35x35 Structure Structure
TM6 224 T 6.36x36 Structure Structure
TM6 225 I 6.37x37 Structure Structure
TM6 226 L 6.38x38 Structure Structure
TM6 227 L 6.39x39 Structure Structure
TM6 228 T 6.40x40 Structure Structure
TM6 229 V 6.41x41 Structure Structure
TM6 230 L 6.42x42 Structure Structure
TM6 231 V 6.43x43 Structure Structure
TM6 232 F 6.44x44 Structure Structure
TM6 233 L 6.45x45 Structure Structure
TM6 234 L 6.46x46 Structure Structure
TM6 235 C 6.47x47 Structure Structure
TM6 236 G 6.48x48 Structure Structure
TM6 237 L 6.49x49 Structure Structure
TM6 238 P 6.50x50 Structure Structure
TM6 239 F 6.51x51 Structure Structure
TM6 240 G 6.52x52 Structure Structure
TM6 241 I 6.53x53 Structure Structure
TM6 242 Q 6.54x54 Structure Structure
TM6 243 W 6.55x55 Structure Structure
TM6 244 F 6.56x56 Structure Structure
TM6 245 L 6.57x57 Structure Structure
TM6 246 I 6.58x58 Structure Structure
TM6 247 L 6.59x59 Structure Structure
TM6 248 W 6.60x60 Structure Structure
TM6 249 I 6.61x61 Structure Structure
TM6 250 W 6.62x62 Structure Structure
ECL3 251 K - Structure Structure
ECL3 252 D - Structure Structure
ECL3 253 S - Structure Structure
ECL3 254 D - Structure Structure
ECL3 255 V - Structure Structure
TM7 256 L 7.30x29 Structure Structure
TM7 257 F 7.31x30 Structure Structure
TM7 258 C 7.32x31 Structure Structure
TM7 259 H 7.33x32 Structure Structure
TM7 260 I 7.34x33 Structure Structure
TM7 261 H 7.35x34 Structure Structure
TM7 262 P 7.36x35 Structure Structure
TM7 263 V 7.37x36 Structure Structure
TM7 264 S 7.38x37 Structure Structure
TM7 265 V 7.39x38 Structure Structure
TM7 266 V 7.40x39 Structure Structure
TM7 267 L 7.41x40 Structure Structure
TM7 268 S 7.42x41 Structure Structure
TM7 269 S 7.43x42 Structure Structure
TM7 270 L 7.44x43 Structure Structure
TM7 271 N 7.45x45 Structure Structure
TM7 272 S 7.46x46 Structure Structure
TM7 273 S 7.47x47 Structure Structure
TM7 274 A 7.48x48 Structure Structure
TM7 275 N 7.49x49 Structure Structure
TM7 276 P 7.50x50 Structure Structure
TM7 277 I 7.51x51 Structure Structure
TM7 278 I 7.52x52 Structure Structure
TM7 279 Y 7.53x53 Structure Structure
TM7 280 F 7.54x54 Structure Structure
TM7 281 F 7.55x55 Structure Structure
TM7 282 V 7.56x56 Structure Structure
TM7 283 G 7.57x57 Structure Structure
TM7 284 S 7.58x58 Structure Structure
TM7 285 F 7.59x59 Structure Structure
C-term 286 R - Structure Structure
C-term 287 K - Structure Structure
C-term 288 Q - Structure Structure
C-term 289 W - Structure Structure
C-term 290 R - AF2 AF2
C-term 291 L - AF2 AF2
C-term 292 Q - AF2 AF2
C-term 293 Q - AF2 AF2
C-term 294 P - AF2 AF2
C-term 295 I - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 209 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM7 G 283 7x57 G.H5 F 354 G.H5.26
Van-der-waals TM7 G 283 7x57 G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 135 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 R 140 34x56 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 140 34x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM2 F 64 2x39 G.H5 G 352 G.H5.24
Polar ICL2 C 139 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 R 214 - G.H5 D 341 G.H5.13
Hydrophobic TM2 F 64 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 64 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 131 3x54 G.H5 L 348 G.H5.20
Polar ICL2 P 134 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 134 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 134 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 L 221 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 225 6x37 G.H5 L 353 G.H5.25
Polar ICL3 R 214 - G.S6 Y 320 G.S6.02
Aromatic ICL3 R 214 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 214 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 214 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 L 216 - G.H5 L 348 G.H5.20
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 C 139 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 C 139 34x55 G.S3 L 194 G.S3.01
Polar ICL2 C 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 139 34x55 G.hns1 R 32 G.hns1.03
Polar ICL3 R 214 - G.S6 I 319 G.S6.01
Hydrophobic TM6 L 221 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM2 F 64 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 F 64 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL3 G 215 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Van-der-waals TM2 N 62 2x37 G.H5 D 350 G.H5.22
Ionic TM4 R 143 4x39 G.HN E 25 G.HN.49
Polar TM4 R 143 4x39 G.HN E 25 G.HN.49
Hydrophobic TM4 R 143 4x39 G.HN E 25 G.HN.49
Van-der-waals TM4 R 143 4x39 G.HN E 25 G.HN.49
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 353 G.H5.25
Aromatic C-term R 286 - G.H5 F 354 G.H5.26
Hydrophobic C-term R 286 - G.H5 F 354 G.H5.26
Van-der-waals C-term R 286 - G.H5 F 354 G.H5.26
Hydrophobic TM5 L 205 5x61 G.H5 L 348 G.H5.20
Polar TM3 S 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 130 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 138 34x54 G.H5 I 343 G.H5.15
Polar ICL2 R 138 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 138 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM3 V 131 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 216 - G.H5 K 345 G.H5.17
Ionic ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 I 135 34x51 G.H5 F 336 G.H5.08
Polar TM3 S 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 130 3x53 G.H5 N 347 G.H5.19
Polar TM3 E 126 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 126 3x49 G.H5 C 351 G.H5.23
Polar ICL2 R 138 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 138 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 138 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 216 - G.H5 I 344 G.H5.16
Hydrophobic TM6 L 221 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 135 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 G 215 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 Y 137 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 137 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 135 34x51 G.H5 T 340 G.H5.12
Ionic TM4 R 143 4x39 G.HN E 28 G.HN.52
Polar TM4 R 143 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 R 143 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 R 143 4x39 G.HN E 28 G.HN.52
Polar ICL2 R 138 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 138 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 P 217 6x29 G.H5 F 354 G.H5.26
Polar ICL2 Y 137 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 137 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 137 34x53 G.H5 C 351 G.H5.23