Refined structure (8U4N) of Gi1 - CXCR4

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 221 from structure (62.4%), 133 from model (37.6%)
Residue sidechains - 215 from structure (60.7%), 139 from model (39.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 283 from structure (86.3%), 45 from model (13.7%)
Residue sidechains - 282 from structure (86.0%), 46 from model (14.0%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 I - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 I - AF2 AF2
N-term 7 Y - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 Y - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 E - AF2 AF2
N-term 15 E - AF2 AF2
N-term 16 M - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 S - AF2 AF2
N-term 19 G - AF2 AF2
N-term 20 D - AF2 AF2
N-term 21 Y - AF2 AF2
N-term 22 D - AF2 AF2
N-term 23 S - AF2 AF2
N-term 24 M - AF2 AF2
N-term 25 K - AF2 AF2
N-term 26 E - AF2 AF2
N-term 27 P - AF2 AF2
N-term 28 C - AF2 AF2
N-term 29 F - AF2 AF2
TM1 30 R 1.24x24 AF2 AF2
TM1 31 E 1.25x25 AF2 AF2
TM1 32 E 1.26x26 AF2 AF2
TM1 33 N 1.27x27 AF2 AF2
TM1 34 A 1.28x28 AF2 AF2
TM1 35 N 1.29x29 AF2 AF2
TM1 36 F 1.30x30 Structure Structure
TM1 37 N 1.31x31 Structure Structure
TM1 38 K 1.32x32 Structure Structure
TM1 39 I 1.33x33 Structure Structure
TM1 40 F 1.34x34 Structure Structure
TM1 41 L 1.35x35 Structure Structure
TM1 42 P 1.36x36 Structure Structure
TM1 43 T 1.37x37 Structure Structure
TM1 44 I 1.38x38 Structure Structure
TM1 45 Y 1.39x39 Structure Structure
TM1 46 S 1.40x40 Structure Structure
TM1 47 I 1.41x41 Structure Structure
TM1 48 I 1.42x42 Structure Structure
TM1 49 F 1.43x43 Structure Structure
TM1 50 L 1.44x44 Structure Structure
TM1 51 T 1.45x45 Structure Structure
TM1 52 G 1.46x46 Structure Structure
TM1 53 I 1.47x47 Structure Structure
TM1 54 V 1.48x48 Structure Structure
TM1 55 G 1.49x49 Structure Structure
TM1 56 N 1.50x50 Structure Structure
TM1 57 G 1.51x51 Structure Structure
TM1 58 L 1.52x52 Structure Structure
TM1 59 V 1.53x53 Structure Structure
TM1 60 I 1.54x54 Structure Structure
TM1 61 L 1.55x55 Structure Structure
TM1 62 V 1.56x56 Structure Structure
TM1 63 M 1.57x57 Structure Structure
TM1 64 G 1.58x58 Structure Structure
TM1 65 Y 1.59x59 Structure Structure
TM1 66 Q 1.60x60 Structure Structure
ICL1 67 K 12.48x48 Structure Structure
ICL1 68 K 12.49x49 Structure Structure
ICL1 69 L 12.50x50 Structure Structure
ICL1 70 R 12.51x51 Structure Structure
TM2 71 S 2.37x37 Structure Structure
TM2 72 M 2.38x38 Structure Structure
TM2 73 T 2.39x39 Structure Structure
TM2 74 D 2.40x40 Structure Structure
TM2 75 K 2.41x41 Structure Structure
TM2 76 Y 2.42x42 Structure Structure
TM2 77 R 2.43x43 Structure Structure
TM2 78 L 2.44x44 Structure Structure
TM2 79 H 2.45x45 Structure Structure
TM2 80 L 2.46x46 Structure Structure
TM2 81 S 2.47x47 Structure Structure
TM2 82 V 2.48x48 Structure Structure
TM2 83 A 2.49x49 Structure Structure
TM2 84 D 2.50x50 Structure Structure
TM2 85 L 2.51x51 Structure Structure
TM2 86 L 2.52x52 Structure Structure
TM2 87 F 2.53x53 Structure Structure
TM2 88 V 2.54x54 Structure Structure
TM2 89 I 2.55x55 Structure Structure
TM2 90 T 2.56x56 Structure Structure
TM2 91 L 2.57x57 Structure Structure
TM2 92 P 2.58x58 Structure Structure
TM2 93 F 2.59x59 Structure Structure
TM2 94 W 2.60x60 Structure Structure
TM2 95 A 2.61x61 Structure Structure
TM2 96 V 2.62x62 Structure Structure
TM2 97 D 2.63x63 Structure Structure
TM2 98 A 2.64x64 Structure Structure
TM2 99 V 2.65x65 Structure Structure
TM2 100 A 2.66x66 Structure Structure
ECL1 101 N 23.49x49 Structure Structure
ECL1 102 W 23.50x50 Structure Structure
ECL1 103 Y 23.51x51 Structure Structure
ECL1 104 F 23.52x52 Structure Structure
TM3 105 G 3.21x21 Structure Structure
TM3 106 N 3.22x22 Structure Structure
TM3 107 F 3.23x23 Structure Structure
TM3 108 L 3.24x24 Structure Structure
TM3 109 C 3.25x25 Structure Structure
TM3 110 K 3.26x26 Structure Structure
TM3 111 A 3.27x27 Structure Structure
TM3 112 V 3.28x28 Structure Structure
TM3 113 H 3.29x29 Structure Structure
TM3 114 V 3.30x30 Structure Structure
TM3 115 I 3.31x31 Structure Structure
TM3 116 Y 3.32x32 Structure Structure
TM3 117 T 3.33x33 Structure Structure
TM3 118 V 3.34x34 Structure Structure
TM3 119 N 3.35x35 Structure AF2
TM3 120 L 3.36x36 Structure Structure
TM3 121 Y 3.37x37 Structure Structure
TM3 122 S 3.38x38 Structure Structure
TM3 123 S 3.39x39 Structure Structure
TM3 124 V 3.40x40 Structure Structure
TM3 125 L 3.41x41 Structure Structure
TM3 126 I 3.42x42 Structure Structure
TM3 127 L 3.43x43 Structure Structure
TM3 128 A 3.44x44 Structure Structure
TM3 129 F 3.45x45 Structure Structure
TM3 130 I 3.46x46 Structure Structure
TM3 131 S 3.47x47 Structure Structure
TM3 132 L 3.48x48 Structure Structure
TM3 133 D 3.49x49 Structure Structure
TM3 134 R 3.50x50 Structure Structure
TM3 135 Y 3.51x51 Structure Structure
TM3 136 L 3.52x52 Structure Structure
TM3 137 A 3.53x53 Structure Structure
TM3 138 I 3.54x54 Structure Structure
TM3 139 V 3.55x55 Structure Structure
TM3 140 H 3.56x56 Structure Structure
ICL2 141 A 34.50x50 Structure Structure
ICL2 142 T 34.51x51 Structure Structure
ICL2 143 N 34.52x52 Structure Structure
ICL2 144 S 34.53x53 Structure Structure
ICL2 145 Q 34.54x54 Structure Structure
ICL2 146 R 34.55x55 Structure Structure
ICL2 147 P 34.56x56 Structure Structure
ICL2 148 R 34.57x57 Structure Structure
TM4 149 K 4.38x38 Structure Structure
TM4 150 L 4.39x39 Structure Structure
TM4 151 L 4.40x40 Structure Structure
TM4 152 A 4.41x41 Structure Structure
TM4 153 E 4.42x42 Structure Structure
TM4 154 K 4.43x43 Structure Structure
TM4 155 V 4.44x44 Structure Structure
TM4 156 V 4.45x45 Structure Structure
TM4 157 Y 4.46x46 Structure Structure
TM4 158 V 4.47x47 Structure Structure
TM4 159 G 4.48x48 Structure Structure
TM4 160 V 4.49x49 Structure Structure
TM4 161 W 4.50x50 Structure Structure
TM4 162 I 4.51x51 Structure Structure
TM4 163 P 4.52x52 Structure Structure
TM4 164 A 4.53x53 Structure Structure
TM4 165 L 4.54x54 Structure Structure
TM4 166 L 4.55x55 Structure Structure
TM4 167 L 4.56x56 Structure Structure
TM4 168 T 4.57x57 Structure Structure
TM4 169 I 4.58x59 Structure Structure
TM4 170 P 4.59x60 Structure Structure
TM4 171 D 4.60x61 Structure Structure
TM4 172 F 4.61x62 Structure Structure
TM4 173 I 4.62x63 Structure Structure
TM4 174 F 4.63x64 Structure Structure
TM4 175 A 4.64x65 Structure Structure
ECL2 176 N - Structure Structure
ECL2 177 V - Structure Structure
ECL2 178 S - Structure Structure
ECL2 179 E - Structure Structure
ECL2 180 A - Structure Structure
ECL2 181 D - Structure Structure
ECL2 182 D - Structure Structure
ECL2 183 R - Structure Structure
ECL2 184 Y - Structure Structure
ECL2 185 I - Structure Structure
ECL2 186 C 45.50x50 Structure Structure
ECL2 187 D 45.51x51 Structure Structure
ECL2 188 R 45.52x52 Structure Structure
ECL2 189 F - Structure Structure
ECL2 190 Y - Structure Structure
ECL2 191 P - Structure Structure
ECL2 192 N - Structure Structure
TM5 193 D 5.32x33 Structure Structure
TM5 194 L 5.33x34 Structure Structure
TM5 195 W 5.34x35 Structure Structure
TM5 196 V 5.35x36 Structure Structure
TM5 197 V 5.36x37 Structure Structure
TM5 198 V 5.37x38 Structure Structure
TM5 199 F 5.38x39 Structure Structure
TM5 200 Q 5.39x40 Structure Structure
TM5 201 F 5.40x41 Structure Structure
TM5 202 Q 5.41x42 Structure Structure
TM5 203 H 5.42x43 Structure Structure
TM5 204 I 5.43x44 Structure Structure
TM5 205 M 5.44x45 Structure Structure
TM5 206 V 5.45x46 Structure Structure
TM5 207 G 5.46x461 Structure Structure
TM5 208 L 5.47x47 Structure Structure
TM5 209 I 5.48x48 Structure Structure
TM5 210 L 5.49x49 Structure Structure
TM5 211 P 5.50x50 Structure Structure
TM5 212 G 5.51x51 Structure Structure
TM5 213 I 5.52x52 Structure Structure
TM5 214 V 5.53x53 Structure Structure
TM5 215 I 5.54x54 Structure Structure
TM5 216 L 5.55x55 Structure Structure
TM5 217 S 5.56x56 Structure Structure
TM5 218 C 5.57x57 Structure Structure
TM5 219 Y 5.58x58 Structure Structure
TM5 220 C 5.59x59 Structure Structure
TM5 221 I 5.60x60 Structure Structure
TM5 222 I 5.61x61 Structure Structure
TM5 223 I 5.62x62 Structure Structure
TM5 224 S 5.63x63 Structure Structure
TM5 225 K 5.64x64 Structure Structure
TM5 226 L 5.65x65 Structure Structure
TM5 227 S 5.66x66 Structure Structure
TM5 228 H 5.67x67 Structure Structure
TM5 229 S 5.68x68 Structure Structure
ICL3 230 K - Structure Structure
ICL3 231 G - Structure Structure
ICL3 232 H - Structure Structure
ICL3 233 Q - Structure Structure
TM6 234 K 6.30x30 Structure Structure
TM6 235 R 6.31x31 Structure Structure
TM6 236 K 6.32x32 Structure Structure
TM6 237 A 6.33x33 Structure Structure
TM6 238 L 6.34x34 Structure Structure
TM6 239 K 6.35x35 Structure Structure
TM6 240 T 6.36x36 Structure Structure
TM6 241 T 6.37x37 Structure Structure
TM6 242 V 6.38x38 Structure Structure
TM6 243 I 6.39x39 Structure Structure
TM6 244 L 6.40x40 Structure Structure
TM6 245 I 6.41x41 Structure Structure
TM6 246 L 6.42x42 Structure Structure
TM6 247 A 6.43x43 Structure Structure
TM6 248 F 6.44x44 Structure Structure
TM6 249 F 6.45x45 Structure Structure
TM6 250 A 6.46x46 Structure Structure
TM6 251 C 6.47x47 Structure Structure
TM6 252 W 6.48x48 Structure Structure
TM6 253 L 6.49x49 Structure Structure
TM6 254 P 6.50x50 Structure Structure
TM6 255 Y 6.51x51 Structure Structure
TM6 256 Y 6.52x52 Structure Structure
TM6 257 I 6.53x53 Structure Structure
TM6 258 G 6.54x54 Structure Structure
TM6 259 I 6.55x55 Structure Structure
TM6 260 S 6.56x56 Structure Structure
TM6 261 I 6.57x57 Structure Structure
TM6 262 D 6.58x58 Structure Structure
TM6 263 S 6.59x59 Structure Structure
TM6 264 F 6.60x60 Structure Structure
TM6 265 I 6.61x61 Structure Structure
TM6 266 L 6.62x62 Structure Structure
TM6 267 L 6.63x63 Structure Structure
TM6 268 E 6.64x64 Structure Structure
ECL3 269 I - Structure Structure
ECL3 270 I - Structure Structure
ECL3 271 K - Structure Structure
ECL3 272 Q - Structure Structure
TM7 273 G 7.24x23 Structure Structure
TM7 274 C 7.25x24 Structure Structure
TM7 275 E 7.26x25 Structure Structure
TM7 276 F 7.27x26 Structure Structure
TM7 277 E 7.28x27 Structure Structure
TM7 278 N 7.29x28 Structure Structure
TM7 279 T 7.30x29 Structure Structure
TM7 280 V 7.31x30 Structure Structure
TM7 281 H 7.32x31 Structure Structure
TM7 282 K 7.33x32 Structure Structure
TM7 283 W 7.34x33 Structure Structure
TM7 284 I 7.35x34 Structure Structure
TM7 285 S 7.36x35 Structure Structure
TM7 286 I 7.37x36 Structure Structure
TM7 287 T 7.38x37 Structure Structure
TM7 288 E 7.39x38 Structure Structure
TM7 289 A 7.40x39 Structure Structure
TM7 290 L 7.41x40 Structure Structure
TM7 291 A 7.42x41 Structure Structure
TM7 292 F 7.43x42 Structure Structure
TM7 293 F 7.44x43 Structure Structure
TM7 294 H 7.45x45 Structure Structure
TM7 295 C 7.46x46 Structure Structure
TM7 296 C 7.47x47 Structure Structure
TM7 297 L 7.48x48 Structure Structure
TM7 298 N 7.49x49 Structure Structure
TM7 299 P 7.50x50 Structure Structure
TM7 300 I 7.51x51 Structure Structure
TM7 301 L 7.52x52 Structure Structure
TM7 302 Y 7.53x53 Structure Structure
TM7 303 A 7.54x54 Structure Structure
TM7 304 F 7.55x55 Structure Structure
TM7 305 L 7.56x56 Structure Structure
H8 306 G 8.47x47 Structure Structure
H8 307 A 8.48x48 Structure Structure
H8 308 K 8.49x49 Structure Structure
H8 309 F 8.50x50 Structure Structure
H8 310 K 8.51x51 Structure Structure
H8 311 T 8.52x52 Structure Structure
H8 312 S 8.53x53 Structure Structure
H8 313 A 8.54x54 Structure Structure
H8 314 Q 8.55x55 Structure Structure
H8 315 H 8.56x56 Structure Structure
H8 316 A 8.57x57 Structure Structure
H8 317 L 8.58x58 Structure Structure
H8 318 T 8.59x59 Structure Structure
C-term 319 S - AF2 AF2
C-term 320 V - AF2 AF2
C-term 321 S - AF2 AF2
C-term 322 R - AF2 AF2
C-term 323 G - AF2 AF2
C-term 324 S - AF2 AF2
C-term 325 S - AF2 AF2
C-term 326 L - AF2 AF2
C-term 327 K - AF2 AF2
C-term 328 I - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 146 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 137 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 137 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 241 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 241 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 134 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 234 6x30 G.H5 K 345 G.H5.17
Polar TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 141 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 141 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 138 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 G 306 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 138 3x54 G.H5 N 347 G.H5.19
Polar TM6 A 237 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 237 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 237 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM2 T 73 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 73 2x39 G.H5 D 350 G.H5.22
Polar TM6 T 240 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 240 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 240 6x36 G.H5 L 353 G.H5.25
Polar TM2 T 73 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 73 2x39 G.H5 C 351 G.H5.23
Polar ICL2 R 148 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 142 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 T 142 34x51 G.H5 I 343 G.H5.15
Ionic H8 K 308 8x49 G.H5 D 350 G.H5.22
Polar H8 K 308 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 308 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 308 8x49 G.H5 D 350 G.H5.22
Ionic TM4 K 149 4x38 G.HN E 28 G.HN.52
Polar TM4 K 149 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 K 149 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 I 138 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Q 145 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 237 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 237 6x33 G.H5 L 348 G.H5.20
Polar H8 A 307 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 244 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 236 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 236 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 T 142 34x51 G.S3 L 194 G.S3.01
Polar ICL3 Q 233 - G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL3 Q 233 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 Q 233 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 138 3x54 G.H5 L 353 G.H5.25
Polar ICL2 A 141 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 K 234 6x30 G.H5 L 348 G.H5.20
Ionic TM6 K 234 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 234 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 234 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 234 6x30 G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 141 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 141 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 A 237 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 226 5x65 G.H5 L 348 G.H5.20
Polar ICL3 H 232 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 H 232 - G.h4s6 D 315 G.h4s6.09
Polar TM3 A 137 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 137 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 137 3x53 G.H5 N 347 G.H5.19