TA1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZSV

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

July 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

30 interactions (Click to see)

LIGANDS

RO5256390 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

3-iodothyronamine, β-phenylethylamine, tyramine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 128 34x51 G.S3 V 79 G.S3.01
Hydrophobic ICL2 A 132 34x55 G.hns1 A 38 G.hns1.02
Hydrophobic TM3 V 124 3x54 G.H5 L 245 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 Q 236 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 Q 236 G.H5.16
Hydrophobic ICL2 L 128 34x51 G.H5 C 231 G.H5.11
Van-der-waals ICL2 L 128 34x51 G.H5 C 231 G.H5.11
Hydrophobic TM6 A 246 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM5 I 223 5x72 G.H5 L 246 G.H5.26
Van-der-waals TM5 I 223 5x72 G.H5 L 246 G.H5.26
Hydrophobic TM3 V 124 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 240 G.H5.20
Hydrophobic ICL2 R 129 34x52 G.hns1 A 39 G.hns1.03
Aromatic ICL2 Y 130 34x53 G.H5 H 239 G.H5.19
Hydrophobic ICL2 Y 130 34x53 G.H5 H 239 G.H5.19
Hydrophobic TM5 I 212 5x61 G.H5 L 245 G.H5.25
Van-der-waals TM5 I 212 5x61 G.H5 L 245 G.H5.25
Polar H8 W 307 8x49 G.H5 Q 242 G.H5.22
Hydrophobic H8 W 307 8x49 G.H5 Q 242 G.H5.22
Van-der-waals H8 W 307 8x49 G.H5 Q 242 G.H5.22
Polar ICL2 Y 130 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 L 128 34x51 G.H2 I 235 G.H2.08
Van-der-waals ICL2 L 128 34x51 G.H2 I 235 G.H2.08
Hydrophobic ICL2 A 132 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 Q 219 5x68 G.H5 L 240 G.H5.20
Hydrophobic ICL2 P 127 34x50 G.H5 H 239 G.H5.19
Hydrophobic TM5 A 216 5x65 G.H5 L 240 G.H5.20
Polar TM5 Q 219 5x68 G.H5 Q 236 G.H5.16
Van-der-waals TM5 Q 219 5x68 G.H5 Q 236 G.H5.16
Ionic TM6 K 245 6x32 G.H5 E 244 G.H5.24
Polar TM6 K 245 6x32 G.H5 E 244 G.H5.24
Hydrophobic TM6 K 245 6x32 G.H5 E 244 G.H5.24
Van-der-waals TM6 K 245 6x32 G.H5 E 244 G.H5.24
Hydrophobic H8 P 306 8x48 G.H5 E 244 G.H5.24
Van-der-waals H8 P 306 8x48 G.H5 E 244 G.H5.24
Hydrophobic TM7 F 304 7x56 G.H5 E 244 G.H5.24
Hydrophobic ICL2 P 127 34x50 G.H2 I 235 G.H2.08
Van-der-waals ICL2 P 127 34x50 G.H2 I 235 G.H2.08
Polar ICL2 L 128 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 128 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 128 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 I 215 5x64 G.H5 Q 236 G.H5.16
Van-der-waals TM5 I 215 5x64 G.H5 Q 236 G.H5.16
Aromatic TM3 R 120 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 Y 243 G.H5.23
Polar TM5 Q 219 5x68 G.H5 R 237 G.H5.17
Hydrophobic TM5 Q 219 5x68 G.H5 R 237 G.H5.17
Van-der-waals TM5 Q 219 5x68 G.H5 R 237 G.H5.17
Hydrophobic TM5 I 223 5x72 G.h4s6 Y 210 G.h4s6.20
Van-der-waals TM5 I 223 5x72 G.h4s6 Y 210 G.h4s6.20
Hydrophobic TM5 Q 219 5x68 G.H5 L 246 G.H5.26
Polar TM6 T 249 6x36 G.H5 E 244 G.H5.24
Hydrophobic TM6 T 249 6x36 G.H5 E 244 G.H5.24
Van-der-waals TM6 T 249 6x36 G.H5 E 244 G.H5.24
Hydrophobic ICL2 L 128 34x51 G.S3 F 81 G.S3.03
Van-der-waals ICL2 L 128 34x51 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 I 223 5x72 G.H5 R 237 G.H5.17
Van-der-waals TM5 I 223 5x72 G.H5 R 237 G.H5.17
Hydrophobic H8 Y 305 8x47 G.H5 E 244 G.H5.24
Polar ICL2 R 129 34x52 G.s2s3 D 77 G.s2s3.01
Van-der-waals ICL2 R 129 34x52 G.s2s3 D 77 G.s2s3.01
Hydrophobic ICL2 L 128 34x51 G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 128 34x51 G.H5 F 228 G.H5.08
Hydrophobic H8 Y 305 8x47 G.H5 Y 243 G.H5.23
Van-der-waals H8 Y 305 8x47 G.H5 Y 243 G.H5.23
Polar ICL2 K 131 34x54 G.hns1 A 37 G.hns1.01
Hydrophobic ICL2 K 131 34x54 G.hns1 A 37 G.hns1.01
Van-der-waals ICL2 K 131 34x54 G.hns1 A 37 G.hns1.01
Hydrophobic ICL2 K 131 34x54 G.hns1 A 38 G.hns1.02
Polar TM3 V 124 3x54 G.H5 Q 236 G.H5.16
Hydrophobic TM3 V 124 3x54 G.H5 Q 236 G.H5.16
Van-der-waals TM3 V 124 3x54 G.H5 Q 236 G.H5.16
Hydrophobic ICL2 L 128 34x51 G.H5 R 232 G.H5.12
Van-der-waals ICL2 L 128 34x51 G.H5 R 232 G.H5.12
Hydrophobic TM6 T 249 6x36 G.H5 L 245 G.H5.25
Van-der-waals TM6 T 249 6x36 G.H5 L 245 G.H5.25
Hydrophobic TM5 A 220 5x69 G.H5 L 246 G.H5.26
Van-der-waals TM5 A 220 5x69 G.H5 L 246 G.H5.26
Hydrophobic ICL2 P 127 34x50 G.H5 R 232 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 R 232 G.H5.12
Polar TM5 N 227 5x76 G.h4s6 T 202 G.h4s6.03
Hydrophobic TM5 N 227 5x76 G.h4s6 T 202 G.h4s6.03
Hydrophobic ICL2 R 129 34x52 G.S3 V 79 G.S3.01
Van-der-waals ICL2 R 129 34x52 G.S3 V 79 G.S3.01
Hydrophobic TM3 A 123 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 123 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 V 124 3x54 G.H5 Y 243 G.H5.23
Hydrophobic TM5 A 216 5x65 G.H5 L 245 G.H5.25
Van-der-waals TM5 A 216 5x65 G.H5 L 245 G.H5.25
Polar TM3 A 123 3x53 G.H5 H 239 G.H5.19
Hydrophobic TM3 A 123 3x53 G.H5 H 239 G.H5.19
Van-der-waals TM3 A 123 3x53 G.H5 H 239 G.H5.19
Hydrophobic TM6 L 250 6x37 G.H5 L 245 G.H5.25