5-HT1D receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7E32

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41586-021-03376-8

PUBLICATION DATE

April 21, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

28 interactions (Click to see)

LIGANDS

5-hydroxytryptamine - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine, 5-HT-moduline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 227 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 227 5x68 G.H5 K 345 G.H5.17
Ionic ICL3 R 238 - G.H4 E 308 G.H4.16
Polar ICL3 R 238 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 R 238 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 R 238 - G.H4 E 308 G.H4.16
Polar H8 N 360 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 N 360 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 N 360 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 E 362 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL3 P 232 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 234 - G.S6 Y 320 G.S6.02
Polar ICL2 R 150 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL3 G 236 - G.S6 F 323 G.S6.05
Polar ICL3 G 236 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 G 236 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 G 236 - G.S6 T 321 G.S6.03
Ionic ICL3 R 238 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 Y 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 Y 235 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Y 235 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 237 - G.H4 Q 304 G.H4.12
Aromatic ICL3 K 237 - G.S6 F 323 G.S6.05
Hydrophobic ICL3 K 237 - G.S6 F 323 G.S6.05
Van-der-waals ICL3 K 237 - G.S6 F 323 G.S6.05
Hydrophobic ICL2 A 143 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 143 34x50 G.H5 I 343 G.H5.15
Aromatic TM6 R 295 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 295 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 295 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM7 F 359 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 359 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 228 5x69 G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 234 - G.H5 D 341 G.H5.13
Polar ICL3 Y 235 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 Y 235 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 Y 235 - G.H4 Q 304 G.H4.12
Hydrophobic TM6 R 288 6x22 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 I 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 348 G.H5.20
Ionic ICL2 K 148 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 148 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 148 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 148 34x55 G.s2s3 D 193 G.s2s3.02
Polar TM6 K 298 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 298 6x32 G.H5 G 352 G.H5.24
Polar TM3 A 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 234 - G.H5 D 337 G.H5.09
Van-der-waals ICL2 K 148 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM3 I 140 3x54 G.H5 C 351 G.H5.23
Polar ICL2 K 148 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 148 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 148 34x55 G.hns1 R 32 G.hns1.03
Ionic TM5 R 227 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 227 5x68 G.H5 D 341 G.H5.13
Ionic H8 E 361 8x48 G.H5 K 349 G.H5.21
Polar H8 E 361 8x48 G.H5 K 349 G.H5.21
Polar ICL2 S 147 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 K 237 - G.H4 A 301 G.H4.08
Polar ICL3 L 234 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 L 234 - G.S6 T 321 G.S6.03
Hydrophobic TM6 I 302 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 I 302 6x36 G.H5 G 352 G.H5.24
Ionic ICL3 K 237 - G.H4 E 297 G.H4.04
Polar ICL3 K 237 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 K 237 - G.H4 E 297 G.H4.04
Ionic TM6 R 288 6x22 G.H4 E 308 G.H4.16
Polar TM6 R 288 6x22 G.H4 E 308 G.H4.16
Hydrophobic ICL2 L 144 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 144 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 144 34x51 G.H5 F 336 G.H5.08
Polar ICL3 Y 235 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 Y 235 - G.S6 T 321 G.S6.03
Hydrophobic TM6 L 303 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 Y 235 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 L 234 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 L 234 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 L 144 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 144 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 I 220 5x61 G.H5 L 353 G.H5.25
Van-der-waals ICL2 A 143 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 A 224 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 144 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 234 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 R 238 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 R 238 - G.H4 Q 304 G.H4.12
Hydrophobic TM6 E 287 6x21 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 E 287 6x21 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 A 299 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 143 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 302 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 A 224 5x65 G.H5 L 353 G.H5.25
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 R 227 5x68 G.H5 F 354 G.H5.26