Structure information

5-HT1D receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7E32

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-03376-8

PUBLICATION DATE

April 21, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5-hydroxytryptamine D118 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-hydroxytryptamine I119 3.33x33 TM3 hydrophobic
5-hydroxytryptamine I119 3.33x33 TM3 Van der Waals
5-hydroxytryptamine C122 3.36x36 TM3 polar (hydrogen bond)
5-hydroxytryptamine S201 5.42x43 TM5 Van der Waals
5-hydroxytryptamine A205 5.46x461 TM5 Van der Waals
5-hydroxytryptamine W314 6.48x48 TM6 Van der Waals
5-hydroxytryptamine F317 6.51x51 TM6 hydrophobic
5-hydroxytryptamine F317 6.51x51 TM6 Van der Waals
5-hydroxytryptamine F318 6.52x52 TM6 Van der Waals
5-hydroxytryptamine F318 6.52x52 TM6 hydrophobic
5-hydroxytryptamine S321 6.55x55 TM6 Van der Waals
5-hydroxytryptamine S321 6.55x55 TM6 polar (hydrogen bond)
5-hydroxytryptamine Y346 7.43x42 TM7 polar (hydrogen bond)

Ligands

5-hydroxytryptamine

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Residue Diagrams

A N S L V T A L T I V S L V V A L S I K 1 G S L A T T D L L V S L I V M P I S I A Y 2 V C L H L I S A T C C T I D S S L W I D 3 A A T M I A I V W A I S I C I S I P P L 4 Y L I I L L V S P I Y F A G C T S Y I T Y 5 G I I L G A F I I C W L P F F V V S L V 6 I P N I L S N L Y G L W T F F D F L A 7
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ICL1 R K L H ICL1ECL1 T W N F ECL1ICL2 A L E Y S K R R ICL2ECL2 Q A K A Q E E M S D C L V N T S ECL2ICL3 L Y G K R F T T A H L I T G S A G S S L C S L N S S L H E G H S H S A G S P L F F N H V K I K L A D S A L E R K ICL3ECL3 R D S C W I ECL3N-term M S P L N Q S A E G L P Q E A S N R S L N A T E T S E A W D P R T N-termC-term P F R K A S C-term L Q A L K I S L A V V L S V I T L A T V L S N A F V L T T I L L T T P A N Y L I G S L A T T D L L V S I L V M P I S I A Y T I T H G Q I L C D I W L S S D I T C C T A S I L H L C V I A L D R Y W A I T D T A G H A A T M I A I V W A I S I C I S I P P L F W R Q I S Y T I Y S T C G A F Y I P S V L L I I L Y G R I Y R A A R N R I L N P P S R I S A A R E R K A T K I L G I I L G A F I I C W L P F F V V S L V L P I C H P A L F D F F T W L G Y L N S L I N P I I Y T V F N E E F Q K F R Q A I V
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1D receptor
TM3
3x32 3.32x32 D118
3x33 3.33x33 I119
3x36 3.36x36 C122
TM5
5x43 5.42x43 S201
5x461 5.46x461 A205
TM6
6x48 6.48x48 W314
6x51 6.51x51 F317
6x52 6.52x52 F318
6x55 6.55x55 S321
TM7
7x42 7.43x42 Y346