C3a receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

May 10, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

C3a anaphylatoxin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

C5a, C3a



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 M 363 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 363 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL3 F 368 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 F 368 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 367 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 I 128 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 M 363 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 M 363 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Polar TM6 K 374 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 374 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 Q 131 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 Q 131 34x54 G.S3 L 194 G.S3.01
Polar TM2 N 57 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 N 57 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 N 57 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL3 K 370 - G.H5 F 354 G.H5.26
Hydrophobic TM5 I 359 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 359 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 Y 356 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 124 3x54 G.H5 L 348 G.H5.20
Aromatic ICL3 F 368 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 F 368 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 F 368 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 M 363 5x65 G.H5 K 345 G.H5.17
Polar TM6 T 375 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 375 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 375 6x33 G.H5 L 353 G.H5.25
Polar ICL3 K 370 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 K 370 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 K 370 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 124 3x54 G.H5 I 344 G.H5.16
Polar TM6 K 374 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 374 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 374 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL3 F 368 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 F 368 - G.H5 F 334 G.H5.06
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Ionic ICL3 R 367 - G.H5 D 337 G.H5.09
Polar ICL3 R 367 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 367 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 367 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 Q 372 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 Q 372 - G.H5 F 354 G.H5.26
Hydrophobic ICL4 L 438 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 L 438 - G.H5 G 352 G.H5.24
Polar TM6 K 374 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 Q 131 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 131 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Polar ICL2 N 132 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 V 378 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 378 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 G 439 8x47 G.H5 G 352 G.H5.24