GPR84 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

June 21, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

6-nonylpyridine-2,4-diol - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 V 205 5x65 G.H5 I 344 G.H5.16
Polar TM6 K 316 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 316 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 212 5x72 G.H5 A 338 G.H5.10
Hydrophobic TM6 V 317 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 V 317 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 122 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 122 3x54 G.H5 L 348 G.H5.20
Polar TM3 L 121 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 121 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 121 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 212 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 L 212 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM6 M 320 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 320 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 121 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 C 351 G.H5.23
Ionic ICL2 K 126 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 126 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 126 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 A 208 5x68 G.H5 I 344 G.H5.16
Polar TM5 Y 215 5x75 G.H5 Q 333 G.H5.05
Hydrophobic TM5 Y 215 5x75 G.H5 Q 333 G.H5.05
Van-der-waals TM5 Y 215 5x75 G.H5 Q 333 G.H5.05
Hydrophobic TM6 V 317 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 317 6x33 G.H5 F 354 G.H5.26
Polar TM5 Y 215 5x75 G.H5 F 334 G.H5.06
Aromatic TM5 Y 215 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM5 Y 215 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 Y 215 5x75 G.H5 F 334 G.H5.06
Aromatic ICL3 F 314 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 F 314 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 F 314 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 126 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 122 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 212 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM3 I 122 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 122 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 122 3x54 G.H5 C 351 G.H5.23
Polar TM3 R 118 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 118 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 118 3x50 G.H5 C 351 G.H5.23
Polar TM5 Y 215 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 Y 215 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 Y 215 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 I 201 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 201 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 122 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 122 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 217 - G.S6 F 323 G.S6.05
Hydrophobic TM6 K 316 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 316 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 118 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 217 - G.H4 A 301 G.H4.08
Hydrophobic TM5 V 205 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 Y 198 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM6 C 321 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 N 374 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 212 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 Y 215 5x75 G.S6 H 322 G.S6.04
Polar H8 R 375 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 R 375 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 R 375 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 212 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM2 F 55 2x39 G.H5 C 351 G.H5.23