RXFP4 - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7YK6

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41467-023-36182-Z

PUBLICATION DATE

March 1, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

26 interactions (Click to see)

LIGANDS

CHEMBL4522365 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

relaxin-3 (B chain), relaxin-3, INSL5



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 149 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 149 - G.S1 V 34 G.S1.02
Polar TM3 R 139 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 V 244 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM6 V 248 6x37 G.H5 L 354 G.H5.25
Polar ICL2 G 150 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 G 150 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 G 150 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 231 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 L 231 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM6 D 240 6x29 G.H5 F 355 G.H5.26
Polar ICL3 R 236 - G.S6 I 320 G.S6.01
Hydrophobic ICL3 R 236 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 236 - G.S6 Y 321 G.S6.02
Hydrophobic TM6 V 244 6x33 G.H5 L 354 G.H5.25
Ionic ICL3 R 236 - G.h4s6 E 319 G.h4s6.12
Polar TM3 V 142 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 F 230 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM3 V 143 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 143 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 R 237 6x26 G.H5 K 346 G.H5.17
Van-der-waals TM6 R 237 6x26 G.H5 K 346 G.H5.17
Hydrophobic ICL2 G 148 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 237 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM3 V 142 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 V 142 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM6 V 243 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 V 243 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 V 244 6x33 G.H5 F 355 G.H5.26
Polar TM6 S 247 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 247 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 247 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 139 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 149 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 P 149 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 149 - G.H5 I 344 G.H5.15
Hydrophobic ICL3 R 234 - G.H5 I 345 G.H5.16
Hydrophobic TM5 L 227 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 L 227 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 143 3x54 G.H5 N 348 G.H5.19
Hydrophobic ICL2 G 150 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 227 5x61 G.H5 L 349 G.H5.20
Hydrophobic H8 R 313 8x47 G.H5 G 353 G.H5.24