GPR34 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8K4N

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Oct. 25, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

60 interactions (Click to see)

LIGANDS

(2R)-2-azanyl-3-[oxidanyl-[(2R)-2-oxidanyl-3-tetradec-9-enoyloxy-propoxy]phosphoryl]oxy-propanoic acid - Agonist pubchem

PHYSIOLOGICAL LIGANDS

lysophosphatidylserine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 R 252 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 252 - G.H5 D 337 G.H5.09
Hydrophobic TM6 T 264 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 T 264 6x34 G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 160 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 160 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 F 255 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 F 255 - G.S6 Y 320 G.S6.02
Polar TM6 K 260 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Van-der-waals TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Polar ICL3 N 257 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 N 257 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 N 257 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 156 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 156 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 255 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 F 255 - G.H5 D 341 G.H5.13
Hydrophobic C-term Y 327 - G.H5 F 354 G.H5.26
Van-der-waals C-term Y 327 - G.H5 F 354 G.H5.26
Polar TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 156 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 Y 261 6x31 G.H5 I 344 G.H5.16
Van-der-waals TM6 Y 261 6x31 G.H5 I 344 G.H5.16
Hydrophobic TM2 I 89 2x39 G.H5 C 351 G.H5.23
Polar TM3 K 155 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 K 155 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 155 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 P 256 - G.S6 Y 320 G.S6.02
Van-der-waals ICL2 I 160 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 R 252 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 R 252 - G.H5 T 340 G.H5.12
Hydrophobic TM3 R 152 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 152 3x50 G.H5 L 353 G.H5.25
Polar TM6 T 263 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 Y 238 5x58 G.H5 L 353 G.H5.25
Polar TM6 Y 261 6x31 G.H5 K 345 G.H5.17
Polar TM6 T 264 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 264 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 264 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 245 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 S 268 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 268 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 N 267 6x37 G.H5 F 354 G.H5.26
Van-der-waals ICL3 N 257 - G.H5 K 345 G.H5.17
Polar TM2 N 87 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 156 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 156 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL3 R 252 - G.H5 D 341 G.H5.13
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 C 351 G.H5.23