RXFP1 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Feb. 15, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

H2 relaxin - Agonist pubchem chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

relaxin-3, relaxin-1, relaxin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 C 513 3x53 G.H5 Y 1376 G.H5.23
Hydrophobic TM3 C 513 3x53 G.H5 Y 1376 G.H5.23
Van-der-waals TM3 C 513 3x53 G.H5 Y 1376 G.H5.23
Hydrophobic TM6 R 629 6x36 G.H5 L 1378 G.H5.25
Hydrophobic TM6 L 626 6x33 G.H5 L 1378 G.H5.25
Polar TM6 R 629 6x36 G.H5 E 1377 G.H5.24
Hydrophobic TM3 I 514 3x54 G.H5 L 1373 G.H5.20
Van-der-waals TM3 I 514 3x54 G.H5 L 1373 G.H5.20
Hydrophobic ICL2 P 517 - G.H5 I 1368 G.H5.15
Van-der-waals ICL2 P 517 - G.H5 I 1368 G.H5.15
Hydrophobic TM5 V 606 5x65 G.H5 L 1373 G.H5.20
Polar TM2 N 437 2x36 G.H5 Y 1376 G.H5.23
Van-der-waals TM2 N 437 2x36 G.H5 Y 1376 G.H5.23
Polar TM3 I 514 3x54 G.H5 Q 1369 G.H5.16
Hydrophobic TM3 I 514 3x54 G.H5 Q 1369 G.H5.16
Van-der-waals TM3 I 514 3x54 G.H5 Q 1369 G.H5.16
Hydrophobic TM6 L 626 6x33 G.H5 L 1379 G.H5.26
Hydrophobic TM5 M 602 5x61 G.H5 L 1373 G.H5.20
Hydrophobic ICL1 E 436 - G.H5 Q 1375 G.H5.22
Hydrophobic TM3 I 514 3x54 G.H5 H 1372 G.H5.19
Van-der-waals TM3 I 514 3x54 G.H5 H 1372 G.H5.19
Hydrophobic TM3 K 510 3x50 G.H5 L 1378 G.H5.25
Hydrophobic TM6 F 630 6x37 G.H5 L 1378 G.H5.25
Van-der-waals TM6 F 630 6x37 G.H5 L 1378 G.H5.25
Hydrophobic TM5 M 602 5x61 G.H5 L 1378 G.H5.25
Hydrophobic ICL2 P 517 - G.H5 R 1365 G.H5.12
Polar TM3 C 513 3x53 G.H5 H 1372 G.H5.19
Van-der-waals TM3 C 513 3x53 G.H5 H 1372 G.H5.19
Hydrophobic TM6 L 626 6x33 G.H5 L 1373 G.H5.20
Van-der-waals TM6 L 626 6x33 G.H5 L 1373 G.H5.20
Hydrophobic H8 P 687 8x49 G.H5 E 1377 G.H5.24
Van-der-waals H8 P 687 8x49 G.H5 E 1377 G.H5.24
Polar H8 T 685 8x47 G.H5 E 1377 G.H5.24
Hydrophobic H8 T 685 8x47 G.H5 E 1377 G.H5.24
Van-der-waals H8 T 685 8x47 G.H5 E 1377 G.H5.24
Polar TM2 Y 440 2x39 G.H5 Y 1376 G.H5.23
Aromatic TM2 Y 440 2x39 G.H5 Y 1376 G.H5.23
Hydrophobic TM2 Y 440 2x39 G.H5 Y 1376 G.H5.23
Van-der-waals TM2 Y 440 2x39 G.H5 Y 1376 G.H5.23
Hydrophobic TM3 K 510 3x50 G.H5 Y 1376 G.H5.23
Van-der-waals TM3 K 510 3x50 G.H5 Y 1376 G.H5.23
Hydrophobic TM6 I 625 6x32 G.H5 L 1379 G.H5.26
Hydrophobic ICL2 P 517 - G.H5 Q 1369 G.H5.16
Van-der-waals ICL2 P 517 - G.H5 Q 1369 G.H5.16
Ionic TM1 R 430 1x57 G.H5 E 1377 G.H5.24
Polar TM1 R 430 1x57 G.H5 E 1377 G.H5.24
Hydrophobic TM1 R 430 1x57 G.H5 E 1377 G.H5.24
Van-der-waals TM1 R 430 1x57 G.H5 E 1377 G.H5.24