Refined structure (7YS6) of Gs - 5-HT6 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 232 from structure (58.9%), 162 from model (41.1%)
Residue sidechains - 226 from structure (57.4%), 168 from model (42.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 AF2 AF2
G.HN 13 R G.HN.30 AF2 AF2
G.HN 14 N G.HN.31 AF2 AF2
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure AF2
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure AF2
G.HN 20 R G.HN.37 Structure AF2
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure AF2
G.HN 23 N G.HN.40 Structure AF2
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure AF2
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 Structure Structure
G.H1 63 L G.H1.11 Structure Structure
G.H1 64 H G.H1.12 Structure Structure
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure Structure
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 Structure Structure
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 268 from structure (81.0%), 63 from model (19.0%)
Residue sidechains - 260 from structure (78.5%), 71 from model (21.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 V - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 E - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 G - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 T - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 W - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 G - AF2 AF2
N-term 19 P - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 P - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 G - AF2 AF2
TM1 26 S 1.32x32 AF2 AF2
TM1 27 G 1.33x33 AF2 AF2
TM1 28 W 1.34x34 AF2 AF2
TM1 29 V 1.35x35 AF2 AF2
TM1 30 A 1.36x36 AF2 AF2
TM1 31 A 1.37x37 AF2 AF2
TM1 32 A 1.38x38 Structure Structure
TM1 33 L 1.39x39 Structure Structure
TM1 34 C 1.40x40 Structure Structure
TM1 35 V 1.41x41 Structure Structure
TM1 36 V 1.42x42 Structure Structure
TM1 37 I 1.43x43 Structure Structure
TM1 38 A 1.44x44 Structure Structure
TM1 39 L 1.45x45 Structure Structure
TM1 40 T 1.46x46 Structure Structure
TM1 41 A 1.47x47 Structure Structure
TM1 42 A 1.48x48 Structure Structure
TM1 43 A 1.49x49 Structure Structure
TM1 44 N 1.50x50 Structure Structure
TM1 45 S 1.51x51 Structure Structure
TM1 46 L 1.52x52 Structure Structure
TM1 47 L 1.53x53 Structure Structure
TM1 48 I 1.54x54 Structure Structure
TM1 49 A 1.55x55 Structure Structure
TM1 50 L 1.56x56 Structure Structure
TM1 51 I 1.57x57 Structure Structure
TM1 52 C 1.58x58 Structure Structure
TM1 53 T 1.59x59 Structure Structure
TM1 54 Q 1.60x60 Structure Structure
ICL1 55 P 12.48x48 Structure Structure
ICL1 56 A 12.49x49 Structure Structure
ICL1 57 L 12.50x50 Structure Structure
ICL1 58 R 12.51x51 Structure Structure
TM2 59 N 2.37x37 Structure Structure
TM2 60 T 2.38x38 Structure Structure
TM2 61 S 2.39x39 Structure Structure
TM2 62 N 2.40x40 Structure Structure
TM2 63 F 2.41x41 Structure Structure
TM2 64 F 2.42x42 Structure Structure
TM2 65 L 2.43x43 Structure Structure
TM2 66 V 2.44x44 Structure Structure
TM2 67 S 2.45x45 Structure Structure
TM2 68 L 2.46x46 Structure Structure
TM2 69 F 2.47x47 Structure Structure
TM2 70 T 2.48x48 Structure Structure
TM2 71 S 2.49x49 Structure Structure
TM2 72 D 2.50x50 Structure Structure
TM2 73 L 2.51x51 Structure Structure
TM2 74 M 2.52x52 Structure Structure
TM2 75 V 2.53x53 Structure Structure
TM2 76 G 2.54x54 Structure Structure
TM2 77 L 2.55x55 Structure Structure
TM2 78 V 2.56x551 Structure Structure
TM2 79 V 2.57x56 Structure Structure
TM2 80 M 2.58x57 Structure Structure
TM2 81 P 2.59x58 Structure Structure
TM2 82 P 2.60x59 Structure Structure
TM2 83 A 2.61x60 Structure Structure
TM2 84 M 2.62x61 Structure Structure
TM2 85 L 2.63x62 Structure AF2
TM2 86 N 2.64x63 Structure Structure
TM2 87 A 2.65x64 Structure Structure
TM2 88 L 2.66x65 Structure AF2
TM2 89 Y 2.67x66 Structure AF2
TM2 90 G 2.68x67 Structure Structure
ECL1 91 R 23.49x49 Structure Structure
ECL1 92 W 23.50x50 Structure Structure
ECL1 93 V 23.51x51 Structure Structure
ECL1 94 L 23.52x52 Structure AF2
TM3 95 A 3.21x21 Structure Structure
TM3 96 R 3.22x22 Structure Structure
TM3 97 G 3.23x23 Structure Structure
TM3 98 L 3.24x24 Structure AF2
TM3 99 C 3.25x25 Structure Structure
TM3 100 L 3.26x26 Structure Structure
TM3 101 L 3.27x27 Structure Structure
TM3 102 W 3.28x28 Structure Structure
TM3 103 T 3.29x29 Structure Structure
TM3 104 A 3.30x30 Structure Structure
TM3 105 F 3.31x31 Structure Structure
TM3 106 D 3.32x32 Structure Structure
TM3 107 V 3.33x33 Structure Structure
TM3 108 M 3.34x34 Structure Structure
TM3 109 C 3.35x35 Structure Structure
TM3 110 C 3.36x36 Structure Structure
TM3 111 S 3.37x37 Structure Structure
TM3 112 A 3.38x38 Structure Structure
TM3 113 S 3.39x39 Structure Structure
TM3 114 I 3.40x40 Structure Structure
TM3 115 L 3.41x41 Structure Structure
TM3 116 N 3.42x42 Structure Structure
TM3 117 L 3.43x43 Structure Structure
TM3 118 C 3.44x44 Structure Structure
TM3 119 L 3.45x45 Structure Structure
TM3 120 I 3.46x46 Structure Structure
TM3 121 S 3.47x47 Structure Structure
TM3 122 L 3.48x48 Structure Structure
TM3 123 D 3.49x49 Structure Structure
TM3 124 R 3.50x50 Structure Structure
TM3 125 Y 3.51x51 Structure Structure
TM3 126 L 3.52x52 Structure Structure
TM3 127 L 3.53x53 Structure Structure
TM3 128 I 3.54x54 Structure Structure
TM3 129 L 3.55x55 Structure Structure
TM3 130 S 3.56x56 Structure Structure
ICL2 131 P 34.50x50 Structure Structure
ICL2 132 L 34.51x51 Structure Structure
ICL2 133 R 34.52x52 Structure Structure
ICL2 134 Y 34.53x53 Structure Structure
ICL2 135 K 34.54x54 Structure Structure
ICL2 136 L 34.55x55 Structure Structure
ICL2 137 R 34.56x56 Structure Structure
ICL2 138 M 34.57x57 Structure Structure
TM4 139 T 4.38x38 Structure Structure
TM4 140 P 4.39x39 Structure Structure
TM4 141 L 4.40x40 Structure Structure
TM4 142 R 4.41x41 Structure Structure
TM4 143 A 4.42x42 Structure Structure
TM4 144 L 4.43x43 Structure Structure
TM4 145 A 4.44x44 Structure Structure
TM4 146 L 4.45x45 Structure Structure
TM4 147 V 4.46x46 Structure Structure
TM4 148 L 4.47x47 Structure Structure
TM4 149 G 4.48x48 Structure Structure
TM4 150 A 4.49x49 Structure Structure
TM4 151 W 4.50x50 Structure Structure
TM4 152 S 4.51x51 Structure Structure
TM4 153 L 4.52x52 Structure Structure
TM4 154 A 4.53x53 Structure Structure
TM4 155 A 4.54x54 Structure Structure
TM4 156 L 4.55x55 Structure Structure
TM4 157 A 4.56x56 Structure Structure
TM4 158 S 4.57x57 Structure Structure
TM4 159 F 4.58x58 Structure Structure
TM4 160 L 4.59x59 Structure Structure
TM4 161 P 4.60x60 Structure Structure
TM4 162 L 4.61x61 Structure Structure
TM4 163 L 4.62x62 Structure Structure
TM4 164 L 4.63x63 Structure AF2
TM4 165 G 4.64x64 Structure Structure
ECL2 166 W - Structure Structure
ECL2 167 H - Structure Structure
ECL2 168 E - Structure Structure
ECL2 169 L - Structure Structure
ECL2 170 G - Structure Structure
ECL2 171 H - Structure Structure
ECL2 172 A - Structure Structure
ECL2 173 R - Structure Structure
ECL2 174 P - Structure Structure
ECL2 175 P - Structure Structure
ECL2 176 V - Structure Structure
ECL2 177 P - Structure Structure
ECL2 178 G - Structure Structure
ECL2 179 Q - Structure Structure
ECL2 180 C 45.50x50 Structure Structure
ECL2 181 R 45.51x51 Structure Structure
ECL2 182 L 45.52x52 Structure Structure
ECL2 183 L - Structure Structure
ECL2 184 A - Structure Structure
TM5 185 S 5.35x36 Structure Structure
TM5 186 L 5.36x37 Structure AF2
TM5 187 P 5.37x38 Structure Structure
TM5 188 F 5.38x39 Structure Structure
TM5 189 V 5.39x40 Structure Structure
TM5 190 L 5.40x41 Structure Structure
TM5 191 V 5.41x42 Structure Structure
TM5 192 A 5.42x43 Structure Structure
TM5 193 S 5.43x44 Structure Structure
TM5 194 G 5.44x45 Structure Structure
TM5 195 L 5.45x46 Structure Structure
TM5 196 T 5.46x461 Structure Structure
TM5 197 F 5.47x47 Structure Structure
TM5 198 F 5.48x48 Structure Structure
TM5 199 L 5.49x49 Structure Structure
TM5 200 P 5.50x50 Structure Structure
TM5 201 S 5.51x51 Structure Structure
TM5 202 G 5.52x52 Structure Structure
TM5 203 A 5.53x53 Structure Structure
TM5 204 I 5.54x54 Structure Structure
TM5 205 C 5.55x55 Structure Structure
TM5 206 F 5.56x56 Structure Structure
TM5 207 T 5.57x57 Structure Structure
TM5 208 Y 5.58x58 Structure Structure
TM5 209 C 5.59x59 Structure Structure
TM5 210 R 5.60x60 Structure Structure
TM5 211 I 5.61x61 Structure Structure
TM5 212 L 5.62x62 Structure Structure
TM5 213 L 5.63x63 Structure Structure
TM5 214 A 5.64x64 Structure Structure
TM5 215 A 5.65x65 Structure Structure
TM5 216 R 5.66x66 Structure Structure
TM5 217 K 5.67x67 Structure Structure
TM5 218 Q 5.68x68 Structure Structure
TM5 219 A 5.69x69 Structure Structure
TM5 220 V 5.70x70 Structure Structure
TM5 221 Q 5.71x71 Structure Structure
TM5 222 V 5.72x72 Structure Structure
TM5 223 A 5.73x73 Structure Structure
TM5 224 S 5.74x74 Structure Structure
TM5 225 L 5.75x75 Structure Structure
TM5 226 T 5.76x76 Structure Structure
ICL3 227 T - AF2 AF2
ICL3 228 G - AF2 AF2
ICL3 229 M - AF2 AF2
ICL3 230 A - AF2 AF2
ICL3 231 S - AF2 AF2
ICL3 232 Q - AF2 AF2
ICL3 233 A - AF2 AF2
ICL3 250 A - AF2 AF2
ICL3 251 D - AF2 AF2
ICL3 252 S - AF2 AF2
ICL3 253 R - AF2 AF2
ICL3 254 R - AF2 AF2
ICL3 255 L - AF2 AF2
ICL3 256 A - AF2 AF2
TM6 257 T 6.24x24 AF2 AF2
TM6 258 K 6.25x25 AF2 AF2
TM6 259 H 6.26x26 AF2 AF2
TM6 260 S 6.27x27 AF2 AF2
TM6 261 R 6.28x28 AF2 AF2
TM6 262 K 6.29x29 AF2 AF2
TM6 263 A 6.30x30 AF2 AF2
TM6 264 L 6.31x31 Structure Structure
TM6 265 K 6.32x32 Structure Structure
TM6 266 A 6.33x33 Structure Structure
TM6 267 S 6.34x34 Structure Structure
TM6 268 L 6.35x35 Structure Structure
TM6 269 T 6.36x36 Structure Structure
TM6 270 L 6.37x37 Structure Structure
TM6 271 G 6.38x38 Structure Structure
TM6 272 I 6.39x39 Structure Structure
TM6 273 L 6.40x40 Structure Structure
TM6 274 L 6.41x41 Structure Structure
TM6 275 G 6.42x42 Structure Structure
TM6 276 M 6.43x43 Structure Structure
TM6 277 F 6.44x44 Structure Structure
TM6 278 F 6.45x45 Structure Structure
TM6 279 V 6.46x46 Structure Structure
TM6 280 T 6.47x47 Structure Structure
TM6 281 W 6.48x48 Structure Structure
TM6 282 L 6.49x49 Structure Structure
TM6 283 P 6.50x50 Structure Structure
TM6 284 F 6.51x51 Structure Structure
TM6 285 F 6.52x52 Structure Structure
TM6 286 V 6.53x53 Structure Structure
TM6 287 A 6.54x54 Structure Structure
TM6 288 N 6.55x55 Structure Structure
TM6 289 I 6.56x56 Structure Structure
TM6 290 V 6.57x57 Structure Structure
TM6 291 Q 6.58x58 Structure Structure
TM6 292 A 6.59x59 Structure Structure
TM6 293 V 6.60x60 Structure AF2
TM6 294 C 6.61x61 Structure Structure
ECL3 295 D - Structure Structure
ECL3 296 C - Structure Structure
ECL3 297 I - Structure Structure
TM7 298 S 7.31x30 Structure Structure
TM7 299 P 7.32x31 Structure Structure
TM7 300 G 7.33x32 Structure Structure
TM7 301 L 7.34x33 Structure Structure
TM7 302 F 7.35x34 Structure Structure
TM7 303 D 7.36x35 Structure Structure
TM7 304 V 7.37x36 Structure Structure
TM7 305 L 7.38x37 Structure Structure
TM7 306 T 7.39x38 Structure Structure
TM7 307 W 7.40x39 Structure Structure
TM7 308 L 7.41x40 Structure Structure
TM7 309 G 7.42x41 Structure Structure
TM7 310 Y 7.43x42 Structure Structure
TM7 311 C 7.44x43 Structure Structure
TM7 312 N 7.45x45 Structure Structure
TM7 313 S 7.46x46 Structure Structure
TM7 314 T 7.47x47 Structure Structure
TM7 315 M 7.48x48 Structure Structure
TM7 316 N 7.49x49 Structure Structure
TM7 317 P 7.50x50 Structure Structure
TM7 318 I 7.51x51 Structure Structure
TM7 319 I 7.52x52 Structure Structure
TM7 320 Y 7.53x53 Structure Structure
TM7 321 P 7.54x54 Structure Structure
TM7 322 L 7.55x55 Structure Structure
TM7 323 F 7.56x56 Structure Structure
H8 324 M 8.47x47 Structure Structure
H8 325 R 8.48x48 Structure Structure
H8 326 D 8.49x49 Structure Structure
H8 327 F 8.50x50 Structure Structure
H8 328 K 8.51x51 Structure Structure
H8 329 R 8.52x52 Structure Structure
H8 330 A 8.53x53 Structure Structure
H8 331 L 8.54x54 Structure Structure
H8 332 G 8.55x55 Structure Structure
H8 333 R 8.56x56 Structure Structure
H8 334 F 8.57x57 Structure Structure
H8 335 L 8.58x58 Structure Structure
H8 336 P 8.59x59 Structure Structure
H8 337 C 8.60x60 AF2 AF2
C-term 338 P - AF2 AF2
C-term 339 R - AF2 AF2
C-term 340 C - AF2 AF2
C-term 341 P - AF2 AF2
C-term 342 R - AF2 AF2
C-term 343 E - AF2 AF2
C-term 344 R - AF2 AF2
C-term 345 Q - AF2 AF2
C-term 346 A - AF2 AF2
C-term 347 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 262 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 K 262 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 L 132 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 V 222 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 V 222 5x72 G.H5 R 385 G.H5.17
Polar TM7 F 323 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 F 323 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 F 323 7x56 G.H5 E 392 G.H5.24
Polar TM5 Q 218 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 218 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 132 34x51 G.S3 V 217 G.S3.01
Polar TM6 T 269 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 132 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 132 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 L 132 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 131 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 131 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 131 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL3 M 229 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 M 229 - G.H4 R 347 G.H4.17
Polar H8 D 326 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 D 326 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 D 326 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM6 T 269 6x36 G.H5 L 393 G.H5.25
Polar TM6 K 258 6x25 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM6 K 258 6x25 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM6 K 258 6x25 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM3 L 127 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 127 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 M 229 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 M 229 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 K 262 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 262 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL3 M 229 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 M 229 - G.H4 L 346 G.H4.16
Ionic ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 133 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 K 258 6x25 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 K 258 6x25 G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL2 R 133 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 K 135 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 Q 218 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 218 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 128 3x54 G.H5 Y 391 G.H5.23
Aromatic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 211 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 270 6x37 G.H5 L 393 G.H5.25
Ionic H8 K 328 8x51 G.H5 E 392 G.H5.24
Polar H8 K 328 8x51 G.H5 E 392 G.H5.24
Hydrophobic H8 K 328 8x51 G.H5 E 392 G.H5.24
Van-der-waals H8 K 328 8x51 G.H5 E 392 G.H5.24
Polar TM6 K 258 6x25 G.h4s6 G 353 G.h4s6.09
Van-der-waals TM6 K 258 6x25 G.h4s6 G 353 G.h4s6.09
Hydrophobic TM3 I 128 3x54 G.H5 L 388 G.H5.20
Polar H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 R 325 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 R 325 8x48 G.H5 R 389 G.H5.21
Hydrophobic ICL3 M 229 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 M 229 - G.H4 D 343 G.H4.13
Ionic H8 R 325 8x48 G.H5 E 392 G.H5.24
Polar H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 325 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 325 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 Q 218 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 132 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM6 A 266 6x33 G.H5 L 393 G.H5.25
Hydrophobic H8 M 324 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 M 324 8x47 G.H5 Y 391 G.H5.23
Polar H8 R 325 8x48 G.H5 Q 390 G.H5.22
Hydrophobic H8 R 325 8x48 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 325 8x48 G.H5 Q 390 G.H5.22
Hydrophobic TM3 L 127 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 127 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 Q 218 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM7 F 323 7x56 G.H5 Y 391 G.H5.23
Van-der-waals TM7 F 323 7x56 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 131 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 131 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM6 K 265 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 265 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM5 T 226 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 V 222 5x72 G.h4s6 Y 358 G.h4s6.20
Polar ICL2 K 135 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 135 34x54 G.hns1 R 38 G.hns1.02