ORF74 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Human herpesvirus 8

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8K4P

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

July 24, 2024

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 Q 244 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 Q 244 - G.h4s6 D 315 G.h4s6.09
Polar ICL3 K 242 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 K 242 - G.S6 I 319 G.S6.01
Hydrophobic TM6 V 249 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 249 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 245 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 245 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 243 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 243 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 143 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 243 - G.H5 D 341 G.H5.13
Hydrophobic TM6 V 249 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 V 249 6x33 G.H5 L 348 G.H5.20
Polar ICL3 Q 244 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 Q 244 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 244 - G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 L 320 8x49 G.H5 K 349 G.H5.21
Hydrophobic ICL2 T 151 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 S 150 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 S 150 - G.H5 I 343 G.H5.15
Polar ICL3 K 242 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 147 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 248 6x32 G.H5 F 354 G.H5.26
Ionic ICL2 K 157 - G.HN E 28 G.HN.52
Polar ICL2 K 157 - G.HN E 28 G.HN.52
Hydrophobic TM5 T 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 252 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM7 G 318 7x57 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 243 - G.H5 K 345 G.H5.17
Hydrophobic TM3 L 146 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 146 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 S 319 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 319 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM5 T 241 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 T 241 5x68 G.H5 D 341 G.H5.13
Polar TM3 R 143 3x50 G.H5 G 352 G.H5.24
Polar TM3 L 146 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 146 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 S 150 - G.H5 I 344 G.H5.16
Hydrophobic TM6 I 253 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 S 153 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 147 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 147 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 143 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 C 351 G.H5.23
Polar ICL2 S 150 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 S 150 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 S 150 - G.H5 N 347 G.H5.19
Hydrophobic TM6 V 249 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 K 242 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 242 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 V 237 5x64 G.H5 I 344 G.H5.16