5-HT2A receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8V6U

RESOLUTION

3.0 Å

REFERENCE

10.1126/SCIENCE.ADN6354

PUBLICATION DATE

May 29, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

31 interactions (Click to see)

LIGANDS

4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol - Agonist pubchem

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine, tryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 181 34x51 G.H5 K 232 G.H5.12
Hydrophobic ICL2 H 183 34x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 I 177 3x54 G.H5 L 236 G.H5.16
Polar ICL2 S 184 34x54 G.H5 N 239 G.H5.19
Van-der-waals ICL2 S 184 34x54 G.H5 N 239 G.H5.19
Hydrophobic ICL2 P 180 34x50 G.H5 I 235 G.H5.15
Hydrophobic TM3 R 173 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 173 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 A 176 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 S 184 34x54 G.H5 I 235 G.H5.15
Polar ICL2 P 180 34x50 G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 180 34x50 G.H5 N 239 G.H5.19
Polar TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 D 172 3x49 G.H5 Y 243 G.H5.23
Polar TM7 Y 380 7x53 G.H5 N 244 G.H5.24
Hydrophobic TM6 A 321 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM3 R 173 3x50 G.H5 L 245 G.H5.25
Van-der-waals TM3 R 173 3x50 G.H5 L 245 G.H5.25
Hydrophobic TM6 A 321 6x33 G.H5 L 240 G.H5.20
Hydrophobic ICL2 P 180 34x50 G.H5 L 236 G.H5.16
Van-der-waals ICL2 P 180 34x50 G.H5 L 236 G.H5.16
Hydrophobic ICL2 I 181 34x51 G.H5 I 235 G.H5.15
Polar ICL2 H 183 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 H 183 34x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 I 181 34x51 G.S3 V 79 G.S3.01
Hydrophobic TM2 T 109 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM6 L 325 6x37 G.H5 L 245 G.H5.25
Polar ICL2 R 185 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 185 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 185 34x55 G.hns1 R 32 G.hns1.03
Polar TM2 T 109 2x39 G.H5 E 242 G.H5.22
Polar TM3 A 176 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 I 177 3x54 G.H5 L 240 G.H5.20
Polar ICL2 R 185 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 N 317 6x29 G.H5 V 246 G.H5.26
Van-der-waals TM7 F 383 7x56 G.H5 N 244 G.H5.24
Polar H8 N 384 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 N 384 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 N 384 8x47 G.H5 N 244 G.H5.24
Hydrophobic TM6 V 324 6x36 G.H5 L 245 G.H5.25
Hydrophobic TM3 I 177 3x54 G.H5 L 245 G.H5.25
Hydrophobic ICL2 I 181 34x51 G.H5 F 228 G.H5.08