GAL2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

F

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XJK

RESOLUTION

3.3 Å

REFERENCE

10.1073/PNAS.2121465119

PUBLICATION DATE

June 29, 2022

3D VIEW

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LIGAND INTERACTIONS

57 interactions (Click to see)

LIGANDS

Galanin, Human - Agonist pubchem

PHYSIOLOGICAL LIGANDS

galanin-like peptide, spexin-1, galanin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 60 2x39 G.H5 Y 243 G.H5.23
Van-der-waals TM2 T 60 2x39 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 L 131 - G.H5 K 232 G.H5.12
Hydrophobic ICL2 L 131 - G.S3 V 79 G.S3.01
Polar TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 I 127 3x54 G.H5 L 245 G.H5.25
Polar ICL2 R 134 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 134 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 134 - G.hns1 R 32 G.hns1.03
Polar TM7 Y 292 7x53 G.H5 N 244 G.H5.24
Hydrophobic TM7 Y 292 7x53 G.H5 N 244 G.H5.24
Van-der-waals TM7 Y 292 7x53 G.H5 N 244 G.H5.24
Polar ICL2 R 137 - G.H5 Y 243 G.H5.23
Van-der-waals ICL2 R 137 - G.H5 Y 243 G.H5.23
Ionic ICL2 E 135 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 135 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 135 - G.hns1 R 32 G.hns1.03
Hydrophobic TM7 A 293 7x54 G.H5 N 244 G.H5.24
Hydrophobic TM3 I 127 3x54 G.H5 L 236 G.H5.16
Van-der-waals TM3 I 127 3x54 G.H5 L 236 G.H5.16
Hydrophobic ICL2 P 130 - G.H5 L 236 G.H5.16
Polar TM2 T 60 2x39 G.H5 E 242 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 E 242 G.H5.22
Hydrophobic TM6 K 233 6x32 G.H5 L 245 G.H5.25
Van-der-waals TM6 K 233 6x32 G.H5 L 245 G.H5.25
Hydrophobic TM6 K 233 6x32 G.H5 V 246 G.H5.26
Hydrophobic TM6 V 234 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 V 234 6x33 G.H5 L 245 G.H5.25
Hydrophobic TM6 M 237 6x36 G.H5 N 244 G.H5.24
Van-der-waals TM6 M 237 6x36 G.H5 N 244 G.H5.24
Hydrophobic TM3 A 126 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 126 3x53 G.H5 Y 243 G.H5.23
Hydrophobic H8 H 298 8x49 G.H5 R 241 G.H5.21
Polar H8 S 296 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 S 296 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 S 296 8x47 G.H5 N 244 G.H5.24
Hydrophobic ICL2 L 131 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 H 132 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 H 132 - G.S3 V 79 G.S3.01
Polar TM3 D 122 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 D 122 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 D 122 3x49 G.H5 Y 243 G.H5.23
Polar TM3 A 126 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 R 134 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 R 134 - G.S1 L 34 G.S1.02
Hydrophobic TM6 V 234 6x33 G.H5 V 246 G.H5.26
Van-der-waals TM6 V 234 6x33 G.H5 V 246 G.H5.26
Hydrophobic ICL2 P 130 - G.H5 K 232 G.H5.12
Hydrophobic TM6 V 234 6x33 G.H5 L 240 G.H5.20
Van-der-waals TM6 V 234 6x33 G.H5 L 240 G.H5.20
Hydrophobic TM3 R 123 3x50 G.H5 L 245 G.H5.25
Hydrophobic TM6 I 238 6x37 G.H5 L 245 G.H5.25
Hydrophobic TM5 Y 213 5x64 G.H5 L 236 G.H5.16
Van-der-waals ICL2 H 132 - G.s2s3 D 77 G.s2s3.01
Hydrophobic ICL2 L 131 - G.H5 F 228 G.H5.08
Van-der-waals ICL2 L 131 - G.H5 F 228 G.H5.08
Hydrophobic TM6 M 237 6x36 G.H5 L 245 G.H5.25
Van-der-waals TM6 M 237 6x36 G.H5 L 245 G.H5.25
Hydrophobic ICL2 L 131 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 L 131 - G.S1 L 34 G.S1.02
Hydrophobic TM5 L 214 5x65 G.H5 L 236 G.H5.16
Hydrophobic TM3 I 127 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 I 127 3x54 G.H5 L 240 G.H5.20
Hydrophobic ICL2 P 130 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 130 - G.H5 I 235 G.H5.15
Hydrophobic TM6 A 230 6x29 G.H5 V 246 G.H5.26