Refined structure (7EW4) of Gi1 - S1P3 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 228 from structure (64.4%), 126 from model (35.6%)
Residue sidechains - 225 from structure (63.6%), 129 from model (36.4%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 Structure Structure
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure AF2
G.s4h3 239 E G.s4h3.13 Structure AF2
G.s4h3 240 M G.s4h3.14 Structure AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 287 from structure (88.6%), 37 from model (11.4%)
Residue sidechains - 268 from structure (82.7%), 56 from model (17.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 R - AF2 AF2
N-term 9 L - AF2 AF2
N-term 10 Q - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 V - AF2 AF2
N-term 13 R - AF2 AF2
N-term 14 G - AF2 AF2
N-term 15 N - AF2 AF2
N-term 16 E - Structure Structure
N-term 17 T - Structure Structure
N-term 18 L - Structure Structure
N-term 19 R - Structure AF2
N-term 20 E - Structure Structure
N-term 21 H - Structure Structure
N-term 22 Y - Structure Structure
N-term 23 Q - Structure AF2
N-term 24 Y - Structure Structure
N-term 25 V - Structure Structure
N-term 26 G - Structure Structure
N-term 27 K - Structure AF2
N-term 28 L - Structure Structure
N-term 29 A - AF2 AF2
N-term 30 G - AF2 AF2
N-term 31 R - AF2 AF2
N-term 32 L - AF2 AF2
N-term 33 K - AF2 AF2
N-term 34 E - AF2 AF2
N-term 35 A - AF2 AF2
N-term 36 S - AF2 AF2
N-term 37 E - AF2 AF2
N-term 38 G - AF2 AF2
TM1 39 S 1.32x32 Structure Structure
TM1 40 T 1.33x33 Structure Structure
TM1 41 L 1.34x34 Structure Structure
TM1 42 T 1.35x35 Structure Structure
TM1 43 T 1.36x36 Structure Structure
TM1 44 V 1.37x37 Structure Structure
TM1 45 L 1.38x38 Structure Structure
TM1 46 F 1.39x39 Structure Structure
TM1 47 L 1.40x40 Structure Structure
TM1 48 V 1.41x41 Structure Structure
TM1 49 I 1.42x42 Structure Structure
TM1 50 C 1.43x43 Structure Structure
TM1 51 S 1.44x44 Structure Structure
TM1 52 F 1.45x45 Structure Structure
TM1 53 I 1.46x46 Structure Structure
TM1 54 V 1.47x47 Structure Structure
TM1 55 L 1.48x48 Structure Structure
TM1 56 E 1.49x49 Structure Structure
TM1 57 N 1.50x50 Structure Structure
TM1 58 L 1.51x51 Structure AF2
TM1 59 M 1.52x52 Structure AF2
TM1 60 V 1.53x53 Structure Structure
TM1 61 L 1.54x54 Structure Structure
TM1 62 I 1.55x55 Structure Structure
TM1 63 A 1.56x56 Structure Structure
TM1 64 I 1.57x57 Structure Structure
TM1 65 W 1.58x58 Structure AF2
TM1 66 K 1.59x59 Structure AF2
TM1 67 N 1.60x60 Structure Structure
ICL1 68 N 12.48x48 Structure Structure
ICL1 69 K 12.49x49 Structure AF2
ICL1 70 F 12.50x50 Structure Structure
ICL1 71 H 12.51x51 Structure AF2
TM2 72 N 2.37x37 Structure Structure
TM2 73 R 2.38x38 Structure Structure
TM2 74 M 2.39x39 Structure Structure
TM2 75 Y 2.40x40 Structure Structure
TM2 76 F 2.41x41 Structure Structure
TM2 77 F 2.42x42 Structure Structure
TM2 78 I 2.43x43 Structure Structure
TM2 79 G 2.44x44 Structure Structure
TM2 80 N 2.45x45 Structure Structure
TM2 81 L 2.46x46 Structure Structure
TM2 82 A 2.47x47 Structure Structure
TM2 83 L 2.48x48 Structure Structure
TM2 84 C 2.49x49 Structure Structure
TM2 85 D 2.50x50 Structure AF2
TM2 86 L 2.51x51 Structure Structure
TM2 87 L 2.52x52 Structure Structure
TM2 88 A 2.53x53 Structure Structure
TM2 89 G 2.54x54 Structure Structure
TM2 90 I 2.55x55 Structure Structure
TM2 91 A 2.56x56 Structure Structure
TM2 92 Y 2.57x57 Structure Structure
TM2 93 K 2.58x58 Structure Structure
TM2 94 V 2.59x59 Structure Structure
TM2 95 N 2.60x60 Structure Structure
TM2 96 I 2.61x61 Structure Structure
TM2 97 L 2.62x62 Structure Structure
TM2 98 M 2.63x63 Structure Structure
TM2 99 S 2.64x64 Structure Structure
ECL1 100 G 23.47x47 Structure Structure
ECL1 101 K 23.48x48 Structure Structure
ECL1 102 K 23.49x49 Structure Structure
ECL1 103 T 23.50x50 Structure Structure
ECL1 104 F 23.51x501 Structure Structure
ECL1 105 S 23.52x51 Structure Structure
ECL1 106 L 23.53x52 Structure Structure
TM3 107 S 3.21x21 Structure Structure
TM3 108 P 3.22x22 Structure Structure
TM3 109 T 3.23x23 Structure Structure
TM3 110 V 3.24x24 Structure Structure
TM3 111 W 3.25x25 Structure Structure
TM3 112 F 3.26x26 Structure Structure
TM3 113 L 3.27x27 Structure Structure
TM3 114 R 3.28x28 Structure Structure
TM3 115 E 3.29x29 Structure Structure
TM3 116 G 3.30x30 Structure Structure
TM3 117 S 3.31x31 Structure Structure
TM3 118 M 3.32x32 Structure Structure
TM3 119 F 3.33x33 Structure Structure
TM3 120 V 3.34x34 Structure Structure
TM3 121 A 3.35x35 Structure Structure
TM3 122 L 3.36x36 Structure Structure
TM3 123 G 3.37x37 Structure Structure
TM3 124 A 3.38x38 Structure Structure
TM3 125 S 3.39x39 Structure Structure
TM3 126 T 3.40x40 Structure Structure
TM3 127 C 3.41x41 Structure Structure
TM3 128 S 3.42x42 Structure Structure
TM3 129 L 3.43x43 Structure Structure
TM3 130 L 3.44x44 Structure Structure
TM3 131 A 3.45x45 Structure Structure
TM3 132 I 3.46x46 Structure Structure
TM3 133 A 3.47x47 Structure Structure
TM3 134 I 3.48x48 Structure Structure
TM3 135 E 3.49x49 Structure Structure
TM3 136 R 3.50x50 Structure Structure
TM3 137 H 3.51x51 Structure Structure
TM3 138 L 3.52x52 Structure Structure
TM3 139 T 3.53x53 Structure Structure
TM3 140 M 3.54x54 Structure Structure
TM3 141 I 3.55x55 Structure Structure
TM3 142 K 3.56x56 Structure Structure
ICL2 143 M 34.50x50 Structure Structure
ICL2 144 R 34.51x51 Structure Structure
ICL2 145 P 34.52x52 Structure Structure
ICL2 146 Y 34.53x53 Structure Structure
ICL2 147 D 34.54x54 Structure Structure
ICL2 148 A 34.55x55 Structure Structure
ICL2 149 N 34.56x56 Structure Structure
TM4 150 K 4.38x38 Structure Structure
TM4 151 R 4.39x39 Structure Structure
TM4 152 H 4.40x40 Structure Structure
TM4 153 R 4.41x41 Structure Structure
TM4 154 V 4.42x42 Structure Structure
TM4 155 F 4.43x43 Structure Structure
TM4 156 L 4.44x44 Structure Structure
TM4 157 L 4.45x45 Structure Structure
TM4 158 I 4.46x46 Structure Structure
TM4 159 G 4.47x47 Structure Structure
TM4 160 M 4.48x48 Structure Structure
TM4 161 C 4.49x49 Structure Structure
TM4 162 W 4.50x50 Structure Structure
TM4 163 L 4.51x51 Structure Structure
TM4 164 I 4.52x52 Structure Structure
TM4 165 A 4.53x53 Structure Structure
TM4 166 F 4.54x54 Structure Structure
TM4 167 T 4.55x55 Structure Structure
TM4 168 L 4.56x56 Structure Structure
TM4 169 G 4.57x57 Structure Structure
TM4 170 A 4.58x58 Structure Structure
TM4 171 L 4.59x59 Structure Structure
TM4 172 P 4.60x60 Structure Structure
TM4 173 I 4.61x61 Structure Structure
TM4 174 L 4.62x62 Structure Structure
TM4 175 G 4.63x63 Structure Structure
ECL2 176 W - Structure Structure
ECL2 177 N - Structure Structure
ECL2 178 C - Structure Structure
ECL2 179 L - Structure Structure
ECL2 180 H - Structure Structure
ECL2 181 N - Structure Structure
ECL2 182 L - Structure Structure
ECL2 183 P - Structure Structure
ECL2 184 D - Structure Structure
ECL2 185 C - Structure Structure
ECL2 186 S - Structure Structure
ECL2 187 T - Structure Structure
ECL2 188 I - Structure Structure
ECL2 189 L - Structure Structure
ECL2 190 P - Structure Structure
ECL2 191 L - Structure Structure
ECL2 192 Y - Structure Structure
TM5 193 S 5.36x36 Structure Structure
TM5 194 K 5.37x37 Structure Structure
TM5 195 K 5.38x38 Structure Structure
TM5 196 Y 5.39x39 Structure Structure
TM5 197 I 5.40x40 Structure Structure
TM5 198 A 5.41x41 Structure Structure
TM5 199 F 5.42x42 Structure Structure
TM5 200 C 5.43x43 Structure Structure
TM5 201 I 5.44x44 Structure Structure
TM5 202 S 5.45x45 Structure Structure
TM5 203 I 5.46x46 Structure Structure
TM5 204 F 5.47x47 Structure Structure
TM5 205 T 5.48x48 Structure Structure
TM5 206 A 5.49x49 Structure Structure
TM5 207 I 5.50x50 Structure Structure
TM5 208 L 5.51x51 Structure Structure
TM5 209 V 5.52x52 Structure Structure
TM5 210 T 5.53x53 Structure Structure
TM5 211 I 5.54x54 Structure Structure
TM5 212 V 5.55x55 Structure Structure
TM5 213 I 5.56x56 Structure Structure
TM5 214 L 5.57x57 Structure Structure
TM5 215 Y 5.58x58 Structure Structure
TM5 216 A 5.59x59 Structure Structure
TM5 217 R 5.60x60 Structure Structure
TM5 218 I 5.61x61 Structure Structure
TM5 219 Y 5.62x62 Structure Structure
TM5 220 F 5.63x63 Structure Structure
TM5 221 L 5.64x64 Structure Structure
TM5 222 V 5.65x65 Structure Structure
TM5 223 K 5.66x66 Structure Structure
TM5 224 S 5.67x67 Structure Structure
TM5 225 S 5.68x68 Structure Structure
TM5 226 S 5.69x69 Structure Structure
TM5 227 R 5.70x70 Structure Structure
TM5 228 K 5.71x71 Structure Structure
ICL3 229 V - Structure Structure
ICL3 230 A - Structure Structure
TM6 231 N 6.23x23 Structure Structure
TM6 232 H 6.24x24 Structure Structure
TM6 233 N 6.25x25 Structure Structure
TM6 234 N 6.26x26 Structure Structure
TM6 235 S 6.27x27 Structure Structure
TM6 236 E 6.28x28 Structure AF2
TM6 237 R 6.29x29 Structure Structure
TM6 238 S 6.30x30 Structure Structure
TM6 239 M 6.31x31 Structure AF2
TM6 240 A 6.32x32 Structure Structure
TM6 241 L 6.33x33 Structure Structure
TM6 242 L 6.34x34 Structure Structure
TM6 243 R 6.35x35 Structure AF2
TM6 244 T 6.36x36 Structure Structure
TM6 245 V 6.37x37 Structure Structure
TM6 246 V 6.38x38 Structure Structure
TM6 247 I 6.39x39 Structure Structure
TM6 248 V 6.40x40 Structure Structure
TM6 249 V 6.41x41 Structure Structure
TM6 250 S 6.42x42 Structure Structure
TM6 251 V 6.43x43 Structure Structure
TM6 252 F 6.44x44 Structure Structure
TM6 253 I 6.45x45 Structure Structure
TM6 254 A 6.46x46 Structure Structure
TM6 255 C 6.47x47 Structure Structure
TM6 256 W 6.48x48 Structure Structure
TM6 257 S 6.49x49 Structure Structure
TM6 258 P 6.50x50 Structure Structure
TM6 259 L 6.51x51 Structure Structure
TM6 260 F 6.52x52 Structure Structure
TM6 261 I 6.53x53 Structure Structure
TM6 262 L 6.54x54 Structure Structure
TM6 263 F 6.55x55 Structure Structure
TM6 264 L 6.56x56 Structure Structure
TM6 265 I 6.57x57 Structure Structure
TM6 266 D 6.58x58 Structure Structure
TM6 267 V 6.59x59 Structure Structure
TM6 268 A 6.60x60 Structure Structure
TM6 269 C 6.61x61 Structure Structure
ECL3 270 R - Structure Structure
ECL3 271 V - Structure Structure
ECL3 272 Q - Structure Structure
ECL3 273 A - Structure Structure
ECL3 274 C - Structure Structure
TM7 275 P 7.30x29 Structure Structure
TM7 276 I 7.31x30 Structure Structure
TM7 277 L 7.32x31 Structure Structure
TM7 278 F 7.33x32 Structure Structure
TM7 279 K 7.34x33 Structure Structure
TM7 280 A 7.35x34 Structure Structure
TM7 281 Q 7.36x35 Structure Structure
TM7 282 W 7.37x36 Structure Structure
TM7 283 F 7.38x37 Structure Structure
TM7 284 I 7.39x38 Structure Structure
TM7 285 V 7.40x39 Structure Structure
TM7 286 L 7.41x40 Structure Structure
TM7 287 A 7.42x41 Structure Structure
TM7 288 V 7.43x42 Structure Structure
TM7 289 L 7.44x43 Structure Structure
TM7 290 N 7.45x45 Structure Structure
TM7 291 S 7.46x46 Structure Structure
TM7 292 A 7.47x47 Structure Structure
TM7 293 M 7.48x48 Structure Structure
TM7 294 N 7.49x49 Structure Structure
TM7 295 P 7.50x50 Structure Structure
TM7 296 V 7.51x51 Structure Structure
TM7 297 I 7.52x52 Structure Structure
TM7 298 Y 7.53x53 Structure Structure
TM7 299 T 7.54x54 Structure Structure
TM7 300 L 7.55x55 Structure Structure
TM7 301 A 7.56x56 Structure Structure
H8 302 S 8.47x47 Structure Structure
H8 303 K 8.48x48 Structure AF2
H8 304 E 8.49x49 Structure Structure
H8 305 M 8.50x50 Structure Structure
H8 306 R 8.51x51 Structure Structure
H8 307 R 8.52x52 Structure AF2
H8 308 A 8.53x53 Structure Structure
H8 309 F 8.54x54 Structure AF2
H8 310 F 8.55x55 Structure AF2
H8 311 R 8.56x56 Structure AF2
H8 312 L 8.57x57 Structure AF2
H8 313 V 8.58x58 AF2 AF2
H8 314 C 8.59x59 AF2 AF2
C-term 315 N - AF2 AF2
C-term 316 C - AF2 AF2
C-term 317 L - AF2 AF2
C-term 318 V - AF2 AF2
C-term 319 R - AF2 AF2
C-term 320 G - AF2 AF2
C-term 321 R - AF2 AF2
C-term 322 G - AF2 AF2
C-term 323 A - AF2 AF2
C-term 324 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 N 72 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 M 143 34x50 G.H5 I 343 G.H5.15
Polar TM3 K 142 3x56 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 142 3x56 G.H5 N 347 G.H5.19
Hydrophobic TM3 M 140 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 M 143 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 M 143 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 T 139 3x53 G.H5 C 351 G.H5.23
Ionic TM6 R 237 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 237 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 237 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 241 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 241 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 145 34x52 G.S1 E 33 G.S1.01
Hydrophobic ICL2 P 145 34x52 G.S1 V 34 G.S1.02
Polar TM6 N 233 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 N 233 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic H8 S 302 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 V 222 5x65 G.H5 L 348 G.H5.20
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM6 N 234 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 221 5x64 G.H5 I 344 G.H5.16
Polar H8 K 303 8x48 G.H5 F 354 G.H5.26
Polar ICL2 Y 146 34x53 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM5 K 228 5x71 G.H5 D 337 G.H5.09
Polar TM3 R 136 3x50 G.H5 G 352 G.H5.24
Polar ICL2 Y 146 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Y 146 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Y 146 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals TM6 N 233 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 M 140 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 M 140 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 144 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 145 34x52 G.H5 I 343 G.H5.15
Polar ICL2 Y 146 34x53 G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 Y 146 34x53 G.h2s4 G 217 G.h2s4.03
Hydrophobic TM5 I 218 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 237 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 237 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM2 M 74 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 146 34x53 G.S1 E 33 G.S1.01
Van-der-waals ICL2 Y 146 34x53 G.S1 E 33 G.S1.01
Polar TM6 N 233 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 A 240 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 240 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 222 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 145 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 144 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 237 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL3 V 229 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 V 229 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 Y 146 34x53 G.S1 K 35 G.S1.03
Van-der-waals ICL2 Y 146 34x53 G.S1 K 35 G.S1.03
Polar TM3 T 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 M 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 140 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 V 229 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 V 229 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 M 140 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 M 140 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 S 225 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 225 5x68 G.H5 I 344 G.H5.16
Polar TM6 N 234 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 N 234 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 234 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM5 Y 215 5x58 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 237 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 148 34x55 G.HN E 28 G.HN.52