SST4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XMS

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41422-022-00679-X

PUBLICATION DATE

Aug. 3, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

53 interactions (Click to see)

LIGANDS

SOMATOSTATIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

CST-17, SRIF-28, cortistatin-14, SRIF-14



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 148 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 148 3x54 G.H5 I 344 G.H5.16
Polar TM2 T 82 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 82 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 82 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 A 245 5x72 G.S6 Y 320 G.S6.02
Polar TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 A 245 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 148 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 K 237 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 237 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 147 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 238 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 257 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 257 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 A 245 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM6 L 260 6x36 G.H5 L 353 G.H5.25
Polar ICL3 W 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 W 247 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 W 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM4 R 159 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 R 159 4x38 G.HN R 24 G.HN.48
Hydrophobic ICL2 A 155 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 155 - G.hns1 R 32 G.hns1.03
Polar ICL2 L 152 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 F 264 6x40 G.H5 L 353 G.H5.25
Ionic TM6 R 252 6x28 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 252 6x28 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 252 6x28 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 I 257 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 I 257 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 241 5x68 G.H5 I 344 G.H5.16
Ionic TM4 R 159 4x38 G.HN E 28 G.HN.52
Polar TM4 R 159 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 159 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 159 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 R 244 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 A 245 5x72 G.H5 F 334 G.H5.06
Van-der-waals TM5 A 245 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM3 R 144 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 257 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 144 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 148 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 S 253 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 253 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 261 6x37 G.H5 L 353 G.H5.25
Polar TM2 T 82 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 82 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 82 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM5 V 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 234 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 241 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM5 M 238 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 M 238 5x65 G.H5 I 344 G.H5.16