CRF1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6P9X

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.MOLCEL.2020.01.012

PUBLICATION DATE

Feb. 5, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

71 interactions (Click to see)

LIGANDS

Corticoliberin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

corticotrophin-releasing hormone, urocortin 2, urocortin 1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 221 - G.S3 F 219 G.S3.03
Polar TM4 R 227 4x42 G.HN Q 35 G.HN.52
Hydrophobic TM4 R 227 4x42 G.HN Q 35 G.HN.52
Van-der-waals TM4 R 227 4x42 G.HN Q 35 G.HN.52
Hydrophobic TM7 F 362 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 294 5x61 G.H5 L 393 G.H5.25
Polar ICL2 Y 221 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 221 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 Y 221 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 290 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 213 3x54 G.H5 L 393 G.H5.25
Polar ICL2 T 220 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 220 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 T 220 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 220 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 T 220 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 T 220 - G.H5 I 383 G.H5.15
Hydrophobic H8 N 367 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 367 8x47 G.H5 E 392 G.H5.24
Polar TM5 K 297 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 297 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 297 5x64 G.H5 R 385 G.H5.17
Polar TM3 I 217 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 217 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 217 3x58 G.H5 Q 384 G.H5.16
Aromatic ICL2 Y 221 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 Y 221 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 Y 221 - G.S1 H 41 G.S1.02
Hydrophobic TM6 L 319 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 318 6x44 G.H5 L 393 G.H5.25
Ionic TM5 K 297 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 297 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 297 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 297 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 297 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 297 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 297 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 Y 221 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 Y 221 - G.S3 V 217 G.S3.01
Hydrophobic TM6 L 322 6x48 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 217 3x58 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 217 3x58 G.H5 H 387 G.H5.19
Polar TM3 A 216 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 216 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 216 3x57 G.H5 H 387 G.H5.19
Polar ICL2 Y 221 - G.H5 F 376 G.H5.08
Aromatic ICL2 Y 221 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 221 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 Y 221 - G.H5 F 376 G.H5.08
Polar TM5 S 301 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 S 301 5x68 G.H5 R 385 G.H5.17
Polar H8 S 368 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 368 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 217 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 217 3x58 G.H5 L 388 G.H5.20
Aromatic TM2 R 151 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 151 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 151 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 213 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 213 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 221 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 Y 221 - G.H5 I 383 G.H5.15
Hydrophobic TM6 A 315 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM7 Y 363 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 294 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 298 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 298 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 297 5x64 G.H5 L 388 G.H5.20
Polar TM2 R 151 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 151 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 D 224 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 294 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 Y 212 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 212 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM2 H 155 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 155 2x50 G.H5 Y 391 G.H5.23
Polar TM6 K 311 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 311 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 311 6x37 G.H5 L 394 G.H5.26