Refined structure (6OS9) of Gi1 - NTS1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 216 from structure (61.0%), 138 from model (39.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure Structure
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure Structure
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 306 from structure (78.5%), 84 from model (21.5%)
Residue sidechains - 301 from structure (77.2%), 89 from model (22.8%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 R - AF2 AF2
N-term 3 L - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 A - AF2 AF2
N-term 16 A - AF2 AF2
N-term 17 D - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 F - AF2 AF2
N-term 20 Q - AF2 AF2
N-term 21 R - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 Q - AF2 AF2
N-term 24 A - AF2 AF2
N-term 25 G - AF2 AF2
N-term 26 L - AF2 AF2
N-term 27 E - AF2 AF2
N-term 28 E - AF2 AF2
N-term 29 A - AF2 AF2
N-term 30 L - AF2 AF2
N-term 31 L - AF2 AF2
N-term 32 A - AF2 AF2
N-term 33 P - AF2 AF2
N-term 34 G - AF2 AF2
N-term 35 F - AF2 AF2
N-term 36 G - AF2 AF2
N-term 37 N - AF2 AF2
N-term 38 A - AF2 AF2
N-term 39 S - AF2 AF2
N-term 40 G - AF2 AF2
N-term 41 N - AF2 AF2
N-term 42 A - AF2 AF2
N-term 43 S - AF2 AF2
N-term 44 E - AF2 AF2
N-term 45 R - AF2 AF2
N-term 46 V - AF2 AF2
N-term 47 L - AF2 AF2
N-term 48 A - AF2 AF2
N-term 49 A - AF2 AF2
N-term 50 P - Structure Structure
N-term 51 S - Structure Structure
N-term 52 S - Structure Structure
N-term 53 E - Structure Structure
N-term 54 L - Structure Structure
N-term 55 D - Structure Structure
N-term 56 V - Structure Structure
N-term 57 N - Structure Structure
N-term 58 T - Structure Structure
TM1 59 D 1.28x28 Structure Structure
TM1 60 I 1.29x29 Structure Structure
TM1 61 Y 1.30x30 Structure Structure
TM1 62 S 1.31x31 Structure Structure
TM1 63 K 1.32x32 Structure Structure
TM1 64 V 1.33x33 Structure Structure
TM1 65 L 1.34x34 Structure Structure
TM1 66 V 1.35x35 Structure Structure
TM1 67 T 1.36x36 Structure Structure
TM1 68 A 1.37x37 Structure Structure
TM1 69 V 1.38x38 Structure Structure
TM1 70 Y 1.39x39 Structure Structure
TM1 71 L 1.40x40 Structure Structure
TM1 72 A 1.41x41 Structure Structure
TM1 73 L 1.42x42 Structure Structure
TM1 74 F 1.43x43 Structure Structure
TM1 75 V 1.44x44 Structure Structure
TM1 76 V 1.45x45 Structure Structure
TM1 77 G 1.46x46 Structure Structure
TM1 78 T 1.47x47 Structure Structure
TM1 79 V 1.48x48 Structure Structure
TM1 80 G 1.49x49 Structure Structure
TM1 81 N 1.50x50 Structure Structure
TM1 82 T 1.51x51 Structure Structure
TM1 83 V 1.52x52 Structure Structure
TM1 84 T 1.53x53 Structure Structure
TM1 85 A 1.54x54 Structure AF2
TM1 86 F 1.55x55 Structure Structure
TM1 87 T 1.56x56 Structure Structure
TM1 88 L 1.57x57 Structure Structure
TM1 89 A 1.58x58 Structure Structure
TM1 90 R 1.59x59 Structure Structure
TM1 91 K 1.60x60 Structure Structure
ICL1 92 K - Structure AF2
ICL1 93 S - Structure Structure
ICL1 94 L - Structure AF2
ICL1 95 Q - Structure AF2
TM2 96 S 2.34x34 Structure Structure
TM2 97 L 2.35x35 Structure Structure
TM2 98 Q 2.36x36 Structure Structure
TM2 99 S 2.37x37 Structure Structure
TM2 100 T 2.38x38 Structure Structure
TM2 101 V 2.39x39 Structure Structure
TM2 102 H 2.40x40 Structure Structure
TM2 103 Y 2.41x41 Structure Structure
TM2 104 H 2.42x42 Structure Structure
TM2 105 L 2.43x43 Structure Structure
TM2 106 G 2.44x44 Structure Structure
TM2 107 S 2.45x45 Structure Structure
TM2 108 L 2.46x46 Structure Structure
TM2 109 A 2.47x47 Structure Structure
TM2 110 L 2.48x48 Structure Structure
TM2 111 S 2.49x49 Structure Structure
TM2 112 D 2.50x50 Structure Structure
TM2 113 L 2.51x51 Structure Structure
TM2 114 L 2.52x52 Structure Structure
TM2 115 T 2.53x53 Structure Structure
TM2 116 L 2.54x54 Structure Structure
TM2 117 L 2.55x55 Structure Structure
TM2 118 L 2.56x551 Structure Structure
TM2 119 A 2.57x56 Structure Structure
TM2 120 M 2.58x57 Structure Structure
TM2 121 P 2.59x58 Structure Structure
TM2 122 V 2.60x59 Structure Structure
TM2 123 E 2.61x60 Structure Structure
TM2 124 L 2.62x61 Structure Structure
TM2 125 Y 2.63x62 Structure Structure
TM2 126 N 2.64x63 Structure Structure
TM2 127 F 2.65x64 Structure Structure
TM2 128 I 2.66x65 Structure Structure
TM2 129 W 2.67x66 Structure Structure
TM2 130 V 2.68x67 Structure Structure
ECL1 131 H - Structure Structure
ECL1 132 H - Structure Structure
ECL1 133 P 23.49x49 Structure Structure
ECL1 134 W 23.50x50 Structure Structure
ECL1 135 A 23.51x51 Structure Structure
ECL1 136 F 23.52x52 Structure Structure
TM3 137 G 3.21x21 Structure Structure
TM3 138 D 3.22x22 Structure Structure
TM3 139 A 3.23x23 Structure Structure
TM3 140 G 3.24x24 Structure Structure
TM3 141 C 3.25x25 Structure Structure
TM3 142 R 3.26x26 Structure Structure
TM3 143 G 3.27x27 Structure Structure
TM3 144 Y 3.28x28 Structure Structure
TM3 145 Y 3.29x29 Structure Structure
TM3 146 F 3.30x30 Structure Structure
TM3 147 L 3.31x31 Structure Structure
TM3 148 R 3.32x32 Structure Structure
TM3 149 D 3.33x33 Structure Structure
TM3 150 A 3.34x34 Structure Structure
TM3 151 C 3.35x35 Structure Structure
TM3 152 T 3.36x36 Structure Structure
TM3 153 Y 3.37x37 Structure Structure
TM3 154 A 3.38x38 Structure Structure
TM3 155 T 3.39x39 Structure Structure
TM3 156 A 3.40x40 Structure Structure
TM3 157 L 3.41x41 Structure Structure
TM3 158 N 3.42x42 Structure Structure
TM3 159 V 3.43x43 Structure Structure
TM3 160 A 3.44x44 Structure Structure
TM3 161 S 3.45x45 Structure Structure
TM3 162 L 3.46x46 Structure Structure
TM3 163 S 3.47x47 Structure Structure
TM3 164 V 3.48x48 Structure Structure
TM3 165 E 3.49x49 Structure Structure
TM3 166 R 3.50x50 Structure Structure
TM3 167 Y 3.51x51 Structure Structure
TM3 168 L 3.52x52 Structure Structure
TM3 169 A 3.53x53 Structure Structure
TM3 170 I 3.54x54 Structure Structure
TM3 171 C 3.55x55 Structure Structure
TM3 172 H 3.56x56 Structure Structure
ICL2 173 P 34.50x50 Structure Structure
ICL2 174 F 34.51x51 Structure Structure
ICL2 175 K 34.52x52 Structure Structure
ICL2 176 A 34.53x53 Structure Structure
ICL2 177 K 34.54x54 Structure Structure
ICL2 178 T 34.55x55 Structure Structure
ICL2 179 L 34.56x56 Structure Structure
ICL2 180 M 34.57x57 Structure Structure
TM4 181 S 4.38x38 Structure Structure
TM4 182 R 4.39x39 Structure Structure
TM4 183 S 4.40x40 Structure Structure
TM4 184 R 4.41x41 Structure Structure
TM4 185 T 4.42x42 Structure Structure
TM4 186 K 4.43x43 Structure Structure
TM4 187 K 4.44x44 Structure Structure
TM4 188 F 4.45x45 Structure Structure
TM4 189 I 4.46x46 Structure Structure
TM4 190 S 4.47x47 Structure Structure
TM4 191 A 4.48x48 Structure Structure
TM4 192 I 4.49x49 Structure Structure
TM4 193 W 4.50x50 Structure Structure
TM4 194 L 4.51x51 Structure Structure
TM4 195 A 4.52x52 Structure Structure
TM4 196 S 4.53x53 Structure Structure
TM4 197 A 4.54x54 Structure Structure
TM4 198 L 4.55x55 Structure Structure
TM4 199 L 4.56x56 Structure Structure
TM4 200 A 4.57x57 Structure Structure
TM4 201 V 4.58x59 Structure Structure
TM4 202 P 4.59x60 Structure Structure
TM4 203 M 4.60x61 Structure Structure
TM4 204 L 4.61x62 Structure Structure
TM4 205 F 4.62x63 Structure Structure
TM4 206 T 4.63x64 Structure Structure
TM4 207 M 4.64x65 Structure Structure
ECL2 208 G - Structure Structure
ECL2 209 E - Structure Structure
ECL2 210 Q - Structure Structure
ECL2 211 N - Structure Structure
ECL2 212 R - Structure Structure
ECL2 213 S - Structure Structure
ECL2 214 A - Structure Structure
ECL2 215 D - Structure Structure
ECL2 216 G - Structure Structure
ECL2 217 Q - Structure Structure
ECL2 218 H - Structure Structure
ECL2 219 A - Structure Structure
ECL2 220 G - Structure Structure
ECL2 221 G - Structure Structure
ECL2 222 L - Structure Structure
ECL2 223 V - Structure Structure
ECL2 224 C 45.50x50 Structure Structure
ECL2 225 T 45.51x51 Structure Structure
ECL2 226 P 45.52x52 Structure Structure
ECL2 227 T - Structure Structure
ECL2 228 I - Structure Structure
TM5 229 H 5.31x32 Structure Structure
TM5 230 T 5.32x33 Structure Structure
TM5 231 A 5.33x34 Structure Structure
TM5 232 T 5.34x35 Structure Structure
TM5 233 V 5.35x36 Structure Structure
TM5 234 K 5.36x37 Structure Structure
TM5 235 V 5.37x38 Structure Structure
TM5 236 V 5.38x39 Structure Structure
TM5 237 I 5.39x40 Structure Structure
TM5 238 Q 5.40x41 Structure Structure
TM5 239 V 5.41x42 Structure Structure
TM5 240 N 5.42x43 Structure Structure
TM5 241 T 5.43x44 Structure Structure
TM5 242 F 5.44x45 Structure Structure
TM5 243 M 5.45x46 Structure Structure
TM5 244 S 5.46x461 Structure Structure
TM5 245 F 5.47x47 Structure Structure
TM5 246 I 5.48x48 Structure Structure
TM5 247 F 5.49x49 Structure Structure
TM5 248 P 5.50x50 Structure Structure
TM5 249 M 5.51x51 Structure Structure
TM5 250 V 5.52x52 Structure Structure
TM5 251 V 5.53x53 Structure Structure
TM5 252 I 5.54x54 Structure Structure
TM5 253 S 5.55x55 Structure Structure
TM5 254 V 5.56x56 Structure Structure
TM5 255 L 5.57x57 Structure Structure
TM5 256 N 5.58x58 Structure Structure
TM5 257 T 5.59x59 Structure Structure
TM5 258 I 5.60x60 Structure Structure
TM5 259 I 5.61x61 Structure Structure
TM5 260 A 5.62x62 Structure Structure
TM5 261 N 5.63x63 Structure Structure
TM5 262 K 5.64x64 Structure Structure
TM5 263 L 5.65x65 Structure Structure
TM5 264 T 5.66x66 Structure Structure
TM5 265 V 5.67x67 Structure Structure
TM5 266 M 5.68x68 Structure Structure
TM5 267 V 5.69x69 Structure Structure
TM5 268 R 5.70x70 Structure Structure
TM5 269 Q 5.71x71 Structure Structure
TM5 270 A 5.72x72 Structure Structure
TM5 271 A 5.73x73 Structure Structure
TM5 272 E 5.74x74 Structure AF2
TM5 273 Q 5.75x75 Structure Structure
TM5 274 G 5.76x76 AF2 AF2
ICL3 275 Q - AF2 AF2
ICL3 276 V - AF2 AF2
ICL3 277 C - AF2 AF2
ICL3 278 T - AF2 AF2
ICL3 279 V - AF2 AF2
ICL3 280 G - AF2 AF2
ICL3 281 G - AF2 AF2
ICL3 285 T - AF2 AF2
ICL3 286 F - AF2 AF2
ICL3 287 S - AF2 AF2
ICL3 288 M - AF2 AF2
ICL3 289 A - AF2 AF2
ICL3 290 I - AF2 AF2
ICL3 291 E - AF2 AF2
TM6 292 P 6.24x24 AF2 AF2
TM6 293 G 6.25x25 AF2 AF2
TM6 294 R 6.26x26 Structure Structure
TM6 295 V 6.27x27 Structure Structure
TM6 296 Q 6.28x28 Structure Structure
TM6 297 A 6.29x29 Structure Structure
TM6 298 L 6.30x30 Structure Structure
TM6 299 R 6.31x31 Structure Structure
TM6 300 H 6.32x32 Structure Structure
TM6 301 G 6.33x33 Structure Structure
TM6 302 V 6.34x34 Structure Structure
TM6 303 R 6.35x35 Structure Structure
TM6 304 V 6.36x36 Structure Structure
TM6 305 L 6.37x37 Structure Structure
TM6 306 R 6.38x38 Structure Structure
TM6 307 A 6.39x39 Structure Structure
TM6 308 V 6.40x40 Structure Structure
TM6 309 V 6.41x41 Structure Structure
TM6 310 I 6.42x42 Structure Structure
TM6 311 A 6.43x43 Structure Structure
TM6 312 F 6.44x44 Structure Structure
TM6 313 V 6.45x45 Structure Structure
TM6 314 V 6.46x46 Structure Structure
TM6 315 C 6.47x47 Structure Structure
TM6 316 W 6.48x48 Structure Structure
TM6 317 L 6.49x49 Structure Structure
TM6 318 P 6.50x50 Structure Structure
TM6 319 Y 6.51x51 Structure Structure
TM6 320 H 6.52x52 Structure Structure
TM6 321 V 6.53x53 Structure Structure
TM6 322 R 6.54x54 Structure Structure
TM6 323 R 6.55x55 Structure Structure
TM6 324 L 6.56x56 Structure Structure
TM6 325 M 6.57x57 Structure Structure
TM6 326 F 6.58x58 Structure Structure
TM6 327 C 6.59x59 Structure Structure
TM6 328 Y 6.60x60 Structure Structure
TM6 329 I 6.61x61 Structure Structure
ECL3 330 S - Structure Structure
ECL3 331 D - Structure Structure
ECL3 332 E - Structure Structure
ECL3 333 Q - Structure Structure
ECL3 334 W - Structure Structure
TM7 335 T 7.24x23 Structure Structure
TM7 336 P 7.25x24 Structure Structure
TM7 337 F 7.26x25 Structure Structure
TM7 338 L 7.27x26 Structure Structure
TM7 339 Y 7.28x27 Structure Structure
TM7 340 D 7.29x28 Structure Structure
TM7 341 F 7.30x29 Structure Structure
TM7 342 Y 7.31x30 Structure Structure
TM7 343 H 7.32x31 Structure Structure
TM7 344 Y 7.33x32 Structure Structure
TM7 345 F 7.34x33 Structure Structure
TM7 346 Y 7.35x34 Structure Structure
TM7 347 M 7.36x35 Structure Structure
TM7 348 V 7.37x36 Structure Structure
TM7 349 T 7.38x37 Structure Structure
TM7 350 N 7.39x38 Structure Structure
TM7 351 A 7.40x39 Structure Structure
TM7 352 L 7.41x40 Structure Structure
TM7 353 F 7.42x41 Structure Structure
TM7 354 Y 7.43x42 Structure Structure
TM7 355 V 7.44x43 Structure Structure
TM7 356 S 7.45x45 Structure Structure
TM7 357 S 7.46x46 Structure Structure
TM7 358 T 7.47x47 Structure Structure
TM7 359 I 7.48x48 Structure Structure
TM7 360 N 7.49x49 Structure Structure
TM7 361 P 7.50x50 Structure Structure
TM7 362 I 7.51x51 Structure Structure
TM7 363 L 7.52x52 Structure Structure
TM7 364 Y 7.53x53 Structure Structure
TM7 365 N 7.54x54 Structure Structure
TM7 366 L 7.55x55 Structure Structure
TM7 367 V 7.56x56 Structure Structure
H8 368 S 8.47x47 Structure Structure
H8 369 A 8.48x48 Structure Structure
H8 370 N 8.49x49 Structure Structure
H8 371 F 8.50x50 Structure Structure
H8 372 R 8.51x51 Structure Structure
H8 373 H 8.52x52 Structure Structure
H8 374 I 8.53x53 Structure Structure
H8 375 F 8.54x54 Structure Structure
H8 376 L 8.55x55 AF2 AF2
H8 377 A 8.56x56 AF2 AF2
H8 378 T 8.57x57 AF2 AF2
H8 379 L 8.58x58 AF2 AF2
H8 380 A 8.59x59 AF2 AF2
H8 381 C 8.60x60 AF2 AF2
H8 382 L 8.61x61 AF2 AF2
H8 383 C 8.62x62 AF2 AF2
C-term 384 P - AF2 AF2
C-term 385 V - AF2 AF2
C-term 386 W - AF2 AF2
C-term 387 R - AF2 AF2
C-term 388 R - AF2 AF2
C-term 389 R - AF2 AF2
C-term 390 R - AF2 AF2
C-term 391 K - AF2 AF2
C-term 392 R - AF2 AF2
C-term 393 P - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 304 6x36 G.H5 L 353 G.H5.25
Polar TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 G 301 6x33 G.H5 L 353 G.H5.25
Van-der-waals ICL3 E 291 - G.h4s6 K 317 G.h4s6.11
Hydrophobic ICL3 M 288 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 263 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 M 288 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 P 173 34x50 G.H5 I 344 G.H5.16
Polar ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 180 34x57 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 174 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 174 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL3 E 291 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 E 291 - G.h4s6 K 314 G.h4s6.08
Polar ICL3 E 291 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 E 291 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 E 291 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 T 178 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL3 A 289 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 289 - G.h4s6 E 318 G.h4s6.12
Polar TM4 R 182 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 S 181 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 S 181 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 173 34x50 G.H5 T 340 G.H5.12
Polar TM3 A 169 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 169 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 169 3x53 G.H5 N 347 G.H5.19
Polar ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 178 34x55 G.hns1 R 32 G.hns1.03
Polar ICL3 E 291 - G.h4s6 N 311 G.h4s6.02
Hydrophobic ICL2 K 177 34x54 G.H5 I 343 G.H5.15
Ionic TM6 R 294 6x26 G.H5 D 341 G.H5.13
Polar TM6 R 294 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 294 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 294 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL2 K 177 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 177 34x54 G.S3 L 194 G.S3.01
Aromatic ICL3 F 286 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 F 286 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 F 174 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 174 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM4 S 181 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 R 294 6x26 G.H5 F 354 G.H5.26
Hydrophobic TM5 M 266 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 294 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 294 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM6 A 297 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 M 288 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 M 288 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 170 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 170 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 298 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 298 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM2 V 101 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 101 2x39 G.H5 C 351 G.H5.23
Aromatic ICL3 F 286 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 F 286 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 F 286 - G.S6 H 322 G.S6.04
Van-der-waals H8 S 368 8x47 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 174 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 174 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM2 V 101 2x39 G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 177 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 T 178 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 T 178 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Van-der-waals TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 170 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 170 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 266 5x68 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 173 34x50 G.H5 I 343 G.H5.15
Hydrophobic H8 S 368 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 298 6x30 G.H5 F 354 G.H5.26
Van-der-waals ICL3 F 286 - G.S6 F 323 G.S6.05
Hydrophobic TM3 A 169 3x53 G.H5 C 351 G.H5.23
Ionic TM6 R 294 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 294 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 166 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 259 5x61 G.H5 L 353 G.H5.25
Polar ICL3 I 290 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 I 290 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 I 290 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 K 177 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 177 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 L 97 2x35 G.H5 N 347 G.H5.19
Van-der-waals TM2 L 97 2x35 G.H5 N 347 G.H5.19
Polar TM4 S 183 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL2 F 174 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 174 34x51 G.H5 T 340 G.H5.12
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 C 351 G.H5.23