PAC1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6LPB

RESOLUTION

3.9 Å

REFERENCE

10.1038/S41594-020-0386-8

PUBLICATION DATE

March 11, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

84 interactions (Click to see)

LIGANDS

[Ac-His1]PACAP-27 - Agonist gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

PHM, VIP, PACAP-38, PACAP-27, PHI, PHV



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 357 6x44 G.H5 L 383 G.H5.15
Hydrophobic TM6 L 358 6x45 G.H5 L 383 G.H5.15
Hydrophobic TM3 L 255 3x58 G.H5 H 377 G.H5.09
Polar TM5 K 334 5x64 G.H5 Q 374 G.H5.06
Hydrophobic TM5 K 334 5x64 G.H5 Q 374 G.H5.06
Van-der-waals TM5 K 334 5x64 G.H5 Q 374 G.H5.06
Polar H8 G 405 8x48 G.H5 E 382 G.H5.14
Hydrophobic TM3 L 255 3x58 G.H5 L 378 G.H5.10
Hydrophobic ICL2 P 261 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 261 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 331 5x61 G.H5 L 383 G.H5.15
Hydrophobic TM5 K 334 5x64 G.H5 D 371 G.H5.03
Hydrophobic ICL2 F 259 - G.S3 V 217 G.S3.01
Polar TM5 K 334 5x64 G.H5 R 375 G.H5.07
Hydrophobic TM5 L 335 5x65 G.H5 L 384 G.H5.16
Hydrophobic ICL2 F 260 - G.S3 V 217 G.S3.01
Polar TM2 R 185 2x46 G.H5 Q 380 G.H5.12
Hydrophobic TM2 R 185 2x46 G.H5 Q 380 G.H5.12
Van-der-waals TM2 R 185 2x46 G.H5 Q 380 G.H5.12
Polar TM3 E 247 3x50 G.H5 Y 381 G.H5.13
Hydrophobic TM3 Y 250 3x53 G.H5 Y 381 G.H5.13
Van-der-waals TM3 Y 250 3x53 G.H5 Y 381 G.H5.13
Polar TM6 S 354 6x41 G.H5 L 383 G.H5.15
Hydrophobic TM6 S 354 6x41 G.H5 L 383 G.H5.15
Van-der-waals TM6 S 354 6x41 G.H5 L 383 G.H5.15
Hydrophobic ICL2 F 259 - G.s6h5 F 366 G.s6h5.03
Van-der-waals ICL2 F 259 - G.s6h5 F 366 G.s6h5.03
Hydrophobic TM3 L 251 3x54 G.H5 L 383 G.H5.15
Hydrophobic ICL2 T 258 - G.H5 H 377 G.H5.09
Hydrophobic TM3 L 254 3x57 G.H5 H 377 G.H5.09
Van-der-waals TM3 L 254 3x57 G.H5 H 377 G.H5.09
Hydrophobic ICL4 N 404 - G.H5 E 382 G.H5.14
Van-der-waals ICL4 N 404 - G.H5 E 382 G.H5.14
Aromatic TM2 R 185 2x46 G.H5 Y 381 G.H5.13
Hydrophobic TM2 R 185 2x46 G.H5 Y 381 G.H5.13
Van-der-waals TM2 R 185 2x46 G.H5 Y 381 G.H5.13
Hydrophobic TM3 L 251 3x54 G.H5 Y 381 G.H5.13
Van-der-waals TM3 L 251 3x54 G.H5 Y 381 G.H5.13
Polar ICL2 T 258 - G.H5 Q 374 G.H5.06
Hydrophobic ICL2 T 258 - G.H5 Q 374 G.H5.06
Van-der-waals ICL2 T 258 - G.H5 Q 374 G.H5.06
Hydrophobic ICL2 F 259 - G.H5 C 369 G.H5.01
Polar TM3 L 255 3x58 G.H5 Q 374 G.H5.06
Hydrophobic TM3 L 255 3x58 G.H5 Q 374 G.H5.06
Van-der-waals TM3 L 255 3x58 G.H5 Q 374 G.H5.06
Hydrophobic ICL2 T 258 - G.H5 I 373 G.H5.05
Hydrophobic ICL2 F 259 - G.H5 R 370 G.H5.02
Van-der-waals ICL2 F 259 - G.H5 R 370 G.H5.02
Polar TM3 V 256 3x59 G.H5 R 370 G.H5.02
Van-der-waals TM3 V 256 3x59 G.H5 R 370 G.H5.02
Aromatic ICL2 F 259 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 259 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 259 - G.S1 H 41 G.S1.02
Hydrophobic TM5 K 334 5x64 G.H5 L 384 G.H5.16
Hydrophobic ICL2 T 258 - G.H5 R 370 G.H5.02
Hydrophobic ICL2 F 259 - G.H5 I 373 G.H5.05
Van-der-waals ICL2 F 259 - G.H5 I 373 G.H5.05
Hydrophobic ICL2 F 260 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 F 260 - G.s2s3 K 216 G.s2s3.02