ETB receptor - Gt1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Bos taurus

PDB CODE

8XGR

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

April 3, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

102 interactions (Click to see)

LIGANDS

ENDOTHELIN - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

endothelin-3, endothelin-2, endothelin-1



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 202 3x53 G.H5 N 427 G.H5.19
Hydrophobic TM3 A 202 3x53 G.H5 N 427 G.H5.19
Hydrophobic TM3 A 202 3x53 G.H5 L 428 G.H5.20
Polar TM2 N 137 2x40 G.H5 D 430 G.H5.22
Hydrophobic TM2 N 137 2x40 G.H5 D 430 G.H5.22
Van-der-waals TM2 N 137 2x40 G.H5 D 430 G.H5.22
Hydrophobic TM5 M 296 5x61 G.H5 L 433 G.H5.25
Van-der-waals TM5 M 296 5x61 G.H5 L 433 G.H5.25
Hydrophobic H8 K 391 8x48 G.H5 F 434 G.H5.26
Van-der-waals H8 K 391 8x48 G.H5 F 434 G.H5.26
Hydrophobic TM6 V 321 6x33 G.H5 L 433 G.H5.25
Van-der-waals TM6 V 321 6x33 G.H5 L 433 G.H5.25
Hydrophobic TM5 M 300 5x65 G.H5 L 428 G.H5.20
Van-der-waals TM5 M 300 5x65 G.H5 L 428 G.H5.20
Hydrophobic TM6 V 325 6x37 G.H5 L 433 G.H5.25
Van-der-waals TM6 V 325 6x37 G.H5 L 433 G.H5.25
Polar TM3 R 199 3x50 G.H5 C 431 G.H5.23
Hydrophobic TM3 R 199 3x50 G.H5 C 431 G.H5.23
Van-der-waals TM3 R 199 3x50 G.H5 C 431 G.H5.23
Hydrophobic ICL2 K 210 - G.H5 I 423 G.H5.15
Van-der-waals ICL2 K 210 - G.H5 I 423 G.H5.15
Hydrophobic ICL2 W 206 - G.H5 I 424 G.H5.16
Hydrophobic ICL2 S 207 - G.S3 L 274 G.S3.01
Van-der-waals ICL2 S 207 - G.S3 L 274 G.S3.01
Hydrophobic TM2 P 136 2x39 G.H5 D 430 G.H5.22
Ionic TM6 R 318 6x30 G.H5 D 421 G.H5.13
Polar TM6 R 318 6x30 G.H5 D 421 G.H5.13
Hydrophobic TM6 Q 317 6x29 G.H5 F 434 G.H5.26
Van-der-waals TM6 Q 317 6x29 G.H5 F 434 G.H5.26
Polar ICL2 W 206 - G.H5 N 427 G.H5.19
Hydrophobic TM3 D 198 3x49 G.H5 C 431 G.H5.23
Polar ICL2 S 207 - G.s2s3 K 272 G.s2s3.01
Hydrophobic TM6 V 321 6x33 G.H5 L 428 G.H5.20
Hydrophobic TM2 I 140 2x43 G.H5 C 431 G.H5.23
Hydrophobic TM2 P 136 2x39 G.H5 C 431 G.H5.23
Van-der-waals TM2 P 136 2x39 G.H5 C 431 G.H5.23
Hydrophobic TM3 V 203 3x54 G.H5 L 428 G.H5.20
Van-der-waals TM3 V 203 3x54 G.H5 L 428 G.H5.20
Polar ICL2 W 206 - G.H5 T 420 G.H5.12
Van-der-waals ICL2 W 206 - G.H5 T 420 G.H5.12
Hydrophobic TM6 T 324 6x36 G.H5 L 433 G.H5.25
Hydrophobic TM3 R 199 3x50 G.H5 L 433 G.H5.25
Van-der-waals TM7 V 389 7x56 G.H5 F 434 G.H5.26
Hydrophobic TM7 L 386 7x53 G.H5 G 432 G.H5.24
Van-der-waals TM7 L 386 7x53 G.H5 G 432 G.H5.24
Polar TM6 Q 317 6x29 G.h4s6 D 395 G.h4s6.09
Hydrophobic TM6 Q 317 6x29 G.h4s6 D 395 G.h4s6.09
Van-der-waals TM6 Q 317 6x29 G.h4s6 D 395 G.h4s6.09
Hydrophobic TM3 A 202 3x53 G.H5 C 431 G.H5.23
Van-der-waals TM3 A 202 3x53 G.H5 C 431 G.H5.23
Hydrophobic ICL2 I 209 - G.H5 N 427 G.H5.19
Van-der-waals ICL2 I 209 - G.H5 N 427 G.H5.19
Hydrophobic ICL2 W 206 - G.H5 I 423 G.H5.15
Polar TM6 Q 317 6x29 G.H5 K 425 G.H5.17
Van-der-waals TM6 Q 317 6x29 G.H5 K 425 G.H5.17
Van-der-waals ICL1 N 134 12x52 G.H5 D 430 G.H5.22
Polar ICL1 N 134 12x52 G.H5 D 430 G.H5.22
Hydrophobic ICL1 N 134 12x52 G.H5 D 430 G.H5.22