FSH receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8I2G

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41467-023-36170-3

PUBLICATION DATE

March 29, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

65 interactions (Click to see)

LIGANDS

FSHR agonist 1 - Allosteric agonist pubchem ,

Glycoprotein alpha - Agonist ,

Follitropin subunit beta - Agonist

PHYSIOLOGICAL LIGANDS

FSH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 573 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 573 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 573 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 Y 549 5x58 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 475 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 M 475 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 M 475 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 M 475 - G.H5 I 383 G.H5.15
Polar TM3 E 466 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 466 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 466 3x49 G.H5 Y 391 G.H5.23
Hydrophobic H8 T 630 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 630 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 471 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 471 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 471 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 474 - G.H5 H 387 G.H5.19
Polar TM6 S 566 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 S 566 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 L 577 6x40 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 475 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 M 475 - G.S3 V 217 G.S3.01
Polar TM5 V 556 5x65 G.H5 R 385 G.H5.17
Van-der-waals TM5 V 556 5x65 G.H5 R 385 G.H5.17
Polar TM3 T 472 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 T 472 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM6 I 570 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 I 570 6x33 G.H5 L 394 G.H5.26
Polar H8 K 631 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 631 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 573 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 573 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL3 V 562 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 V 562 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 477 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 477 - G.hns1 R 38 G.hns1.02
Polar TM5 T 555 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 T 555 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 T 555 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 552 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 T 470 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 T 470 3x53 G.H5 H 387 G.H5.19
Van-der-waals ICL3 I 561 - G.S6 C 359 G.S6.01
Polar TM3 T 470 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 T 470 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 470 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 A 474 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 474 - G.H5 I 383 G.H5.15
Hydrophobic ICL3 I 561 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 I 561 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 I 570 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL3 I 561 - G.S6 P 361 G.S6.03
Hydrophobic TM6 I 570 6x33 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 474 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 M 475 - G.H5 C 379 G.H5.11
Hydrophobic TM3 I 471 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 471 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 471 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 471 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 556 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 556 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 477 - G.S1 H 41 G.S1.02
Hydrophobic TM6 M 574 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 574 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 475 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 M 475 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 M 475 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 M 475 - G.S1 H 41 G.S1.02
Polar ICL3 N 558 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 N 558 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 I 561 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 L 477 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 L 477 - G.hns1 A 39 G.hns1.03
Polar TM3 R 467 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 467 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 467 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 467 3x50 G.H5 Y 391 G.H5.23