FFA4 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

docosahexaenoic acid - Agonist pubchem gtoplig chembl_ligand drug_central drugbank pubchem

PHYSIOLOGICAL LIGANDS

myristic acid, α-linolenic acid, linoleic acid, oleic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 I 140 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 140 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 140 3x54 G.H5 H 387 G.H5.19
Polar TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 230 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 143 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM5 T 234 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 262 6x34 G.H5 L 388 G.H5.20
Hydrophobic TM6 T 265 6x37 G.H5 Y 391 G.H5.23
Van-der-waals TM6 T 265 6x37 G.H5 Y 391 G.H5.23
Van-der-waals C-term M 323 - G.H5 Q 390 G.H5.22
Polar TM5 T 234 5x65 G.H5 Q 384 G.H5.16
Polar TM3 C 139 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 C 139 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 Q 144 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 143 3x57 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 143 3x57 G.H5 Q 384 G.H5.16
Polar TM6 T 265 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 265 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 143 3x57 G.H5 I 383 G.H5.15
Ionic ICL3 D 259 - G.H5 R 385 G.H5.17