ADGRG2 - Gs

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XKE

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41589-022-01084-6

PUBLICATION DATE

Aug. 10, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

13 interactions (Click to see)

LIGANDS

PRASTERONE - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 715 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL3 Q 812 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 Q 812 - G.H4 L 346 G.H4.16
Hydrophobic ICL3 L 813 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 L 813 - G.h4s6 T 350 G.h4s6.03
Polar TM3 V 716 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 716 3x59 G.H5 R 380 G.H5.12
Hydrophobic ICL3 Q 812 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 N 720 - G.s3h2 V 227 G.s3h2.03
Van-der-waals ICL2 N 720 - G.s3h2 V 227 G.s3h2.03
Polar ICL3 Q 812 - G.S6 C 359 G.S6.01
Polar TM5 K 810 5x67 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 L 813 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 L 813 - G.H4 L 346 G.H4.16
Hydrophobic TM3 L 715 3x58 G.H5 H 387 G.H5.19
Polar TM6 S 826 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 826 6x41 G.H5 L 393 G.H5.25
Polar TM3 L 715 3x58 G.H5 R 380 G.H5.12
Hydrophobic TM5 V 800 5x57 G.H5 L 388 G.H5.20
Polar TM3 H 710 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 H 710 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 710 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 718 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 722 - G.S1 Q 45 G.S1.06
Hydrophobic TM5 I 807 5x64 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 719 - G.H2 F 229 G.H2.02
Hydrophobic TM6 I 827 6x42 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 804 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 833 6x48 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 800 5x57 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 800 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM2 P 653 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 719 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 719 - G.H5 I 383 G.H5.15
Hydrophobic TM5 L 804 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Y 722 - G.S1 K 44 G.S1.05
Van-der-waals ICL2 Y 722 - G.S1 K 44 G.S1.05
Hydrophobic ICL2 F 719 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 Y 722 - G.s1h1 R 48 G.s1h1.02
Aromatic ICL2 F 719 - G.s1h1 H 51 G.s1h1.05
Hydrophobic ICL2 F 719 - G.s1h1 H 51 G.s1h1.05
Van-der-waals ICL2 F 719 - G.s1h1 H 51 G.s1h1.05
Hydrophobic TM2 P 653 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 P 653 2x46 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 V 718 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 718 - G.H5 I 383 G.H5.15
Aromatic ICL2 F 719 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 719 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 719 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 719 - G.s3h2 V 227 G.s3h2.03
Van-der-waals ICL2 F 719 - G.s3h2 V 227 G.s3h2.03
Polar TM6 Q 822 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 Q 822 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM6 Q 822 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 804 5x61 G.H5 L 393 G.H5.25
Polar TM6 S 826 6x41 G.H5 E 392 G.H5.24
Hydrophobic TM6 S 826 6x41 G.H5 E 392 G.H5.24
Van-der-waals TM6 S 826 6x41 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 719 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 719 - G.H5 R 380 G.H5.12
Hydrophobic TM6 L 830 6x45 G.H5 L 393 G.H5.25
Polar ICL2 N 720 - G.s3h2 K 226 G.s3h2.02
Van-der-waals ICL2 N 720 - G.s3h2 K 226 G.s3h2.02
Polar ICL3 Q 812 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 Q 812 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 Q 812 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 L 813 - G.H4 R 347 G.H4.17
Polar TM3 L 715 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 715 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 715 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 M 711 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 711 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 807 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 807 5x64 G.H5 L 388 G.H5.20
Polar TM3 A 714 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 714 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 714 3x57 G.H5 H 387 G.H5.19
Ionic TM6 R 825 6x40 G.H5 E 392 G.H5.24
Polar TM6 R 825 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 807 5x64 G.H5 R 385 G.H5.17
Ionic ICL4 K 875 - G.H5 E 392 G.H5.24
Polar ICL4 K 875 - G.H5 E 392 G.H5.24
Hydrophobic ICL4 K 875 - G.H5 E 392 G.H5.24
Van-der-waals ICL4 K 875 - G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 718 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 718 - G.H5 Q 384 G.H5.16