OR52E4 - Gs

GPCR CLASS (FAMILY)

Class O1 (fish-like odorant)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Dec. 20, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

OCTANOIC ACID - Agonist chembl_ligand pubchem pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL2 Y 134 34x53 G.H5 Y 377 G.H5.23
Hydrophobic TM2 M 61 2x39 G.H5 Y 377 G.H5.23
Van-der-waals TM2 M 61 2x39 G.H5 Y 377 G.H5.23
Polar H8 K 299 8x48 G.H5 E 378 G.H5.24
Hydrophobic H8 K 299 8x48 G.H5 E 378 G.H5.24
Hydrophobic TM3 A 127 3x53 G.H5 Y 377 G.H5.23
Van-der-waals TM3 A 127 3x53 G.H5 Y 377 G.H5.23
Hydrophobic TM2 M 61 2x39 G.H5 Q 376 G.H5.22
Van-der-waals TM2 M 61 2x39 G.H5 Q 376 G.H5.22
Hydrophobic TM5 V 227 5x65 G.H5 L 374 G.H5.20
Hydrophobic TM6 C 243 6x37 G.H5 L 379 G.H5.25
Polar TM6 T 242 6x36 G.H5 E 378 G.H5.24
Van-der-waals TM6 T 242 6x36 G.H5 E 378 G.H5.24
Polar TM2 E 59 2x37 G.H5 Q 376 G.H5.22
Van-der-waals TM2 E 59 2x37 G.H5 Q 376 G.H5.22
Hydrophobic ICL2 L 132 34x51 G.H5 R 366 G.H5.12
Polar ICL2 R 133 34x52 G.s2s3 D 201 G.s2s3.01
Van-der-waals ICL2 R 133 34x52 G.s2s3 D 201 G.s2s3.01
Hydrophobic ICL2 L 132 34x51 G.S3 V 203 G.S3.01
Hydrophobic TM3 R 124 3x50 G.H5 Y 377 G.H5.23
Van-der-waals TM3 R 124 3x50 G.H5 Y 377 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.H5 F 362 G.H5.08
Polar TM3 C 129 3x55 G.H5 R 366 G.H5.12
Polar ICL2 T 135 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic H8 T 298 8x47 G.H5 E 378 G.H5.24
Aromatic ICL2 Y 134 34x53 G.H5 H 373 G.H5.19
Hydrophobic ICL2 Y 134 34x53 G.H5 H 373 G.H5.19
Hydrophobic TM6 A 235 6x29 G.H5 L 380 G.H5.26
Van-der-waals TM6 A 235 6x29 G.H5 L 380 G.H5.26
Van-der-waals TM7 K 297 7x56 G.H5 E 378 G.H5.24
Hydrophobic ICL2 P 131 34x50 G.H5 R 366 G.H5.12
Hydrophobic TM6 K 238 6x32 G.H5 L 380 G.H5.26
Polar ICL3 S 232 - G.H5 R 371 G.H5.17
Hydrophobic TM6 K 238 6x32 G.H5 E 378 G.H5.24
Hydrophobic TM5 I 223 5x61 G.H5 L 379 G.H5.25
Hydrophobic ICL3 L 230 - G.H5 L 374 G.H5.20
Polar TM3 D 123 3x49 G.H5 Y 377 G.H5.23
Van-der-waals TM3 D 123 3x49 G.H5 Y 377 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 A 239 6x33 G.H5 L 379 G.H5.25
Hydrophobic TM3 I 128 3x54 G.H5 L 379 G.H5.25
Polar TM3 A 127 3x53 G.H5 H 373 G.H5.19
Van-der-waals TM3 A 127 3x53 G.H5 H 373 G.H5.19
Hydrophobic ICL2 P 131 34x50 G.H5 I 369 G.H5.15
Van-der-waals ICL2 P 131 34x50 G.H5 I 369 G.H5.15
Hydrophobic ICL2 L 132 34x51 G.H5 I 369 G.H5.15
Hydrophobic ICL2 P 131 34x50 G.H5 Q 370 G.H5.16
Polar TM3 I 128 3x54 G.H5 Q 370 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 Q 370 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 H 373 G.H5.19
Hydrophobic ICL2 P 131 34x50 G.H5 H 373 G.H5.19
Hydrophobic TM4 T 139 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM3 I 128 3x54 G.H5 L 374 G.H5.20