GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

July 5, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

(-)-adrenaline, (-)-noradrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 L 132 - G.S3 F 63 G.S3.03
Hydrophobic TM3 V 128 3x54 G.H5 L 218 G.H5.16
Van-der-waals TM3 V 128 3x54 G.H5 L 218 G.H5.16
Hydrophobic TM5 R 213 5x67 G.H5 L 222 G.H5.20
Polar H8 Q 331 8x48 G.H5 E 224 G.H5.22
Hydrophobic H8 Q 331 8x48 G.H5 E 224 G.H5.22
Hydrophobic ICL2 L 132 - G.H5 C 213 G.H5.11
Hydrophobic H8 Q 331 8x48 G.H5 R 223 G.H5.21
Van-der-waals H8 Q 331 8x48 G.H5 R 223 G.H5.21
Hydrophobic ICL2 P 131 - G.H5 I 217 G.H5.15
Polar TM3 G 127 3x53 G.H5 N 221 G.H5.19
Van-der-waals TM3 G 127 3x53 G.H5 N 221 G.H5.19
Hydrophobic TM5 V 210 5x64 G.H5 L 218 G.H5.16
Polar TM7 C 328 7x55 G.H5 N 226 G.H5.24
Van-der-waals TM7 C 328 7x55 G.H5 N 226 G.H5.24
Hydrophobic TM6 K 269 6x32 G.H5 L 227 G.H5.25
Van-der-waals TM6 K 269 6x32 G.H5 L 227 G.H5.25
Hydrophobic TM5 A 211 5x65 G.H5 L 227 G.H5.25
Hydrophobic TM7 S 329 7x56 G.H5 Y 225 G.H5.23
Van-der-waals TM7 S 329 7x56 G.H5 Y 225 G.H5.23
Polar TM6 K 269 6x32 G.H5 N 226 G.H5.24
Hydrophobic TM6 K 269 6x32 G.H5 N 226 G.H5.24
Van-der-waals TM6 K 269 6x32 G.H5 N 226 G.H5.24
Polar H8 Q 331 8x48 G.H5 N 226 G.H5.24
Hydrophobic H8 Q 331 8x48 G.H5 N 226 G.H5.24
Van-der-waals H8 Q 331 8x48 G.H5 N 226 G.H5.24
Hydrophobic ICL2 L 132 - G.H5 F 210 G.H5.08
Van-der-waals ICL2 L 132 - G.H5 F 210 G.H5.08
Hydrophobic ICL2 L 132 - H.hehf H 16 H.hehf.01
Van-der-waals ICL2 L 132 - H.hehf H 16 H.hehf.01
Hydrophobic TM5 A 211 5x65 G.H5 L 222 G.H5.20
Polar TM6 A 270 6x33 G.H5 L 227 G.H5.25
Hydrophobic TM6 A 270 6x33 G.H5 L 227 G.H5.25
Hydrophobic ICL2 L 132 - G.H5 K 214 G.H5.12
Van-der-waals TM7 S 329 7x56 G.H5 E 224 G.H5.22
Hydrophobic TM7 S 329 7x56 G.H5 N 226 G.H5.24
Van-der-waals TM7 S 329 7x56 G.H5 N 226 G.H5.24
Hydrophobic ICL2 T 136 - H.HE A 14 H.HE.12
Hydrophobic TM6 T 273 6x36 G.H5 L 227 G.H5.25
Hydrophobic ICL2 L 132 - G.S3 V 61 G.S3.01
Hydrophobic TM5 R 213 5x67 G.H5 V 228 G.H5.26
Van-der-waals TM5 R 213 5x67 G.H5 V 228 G.H5.26
Aromatic TM3 R 124 3x50 G.H5 Y 225 G.H5.23
Hydrophobic TM3 R 124 3x50 G.H5 Y 225 G.H5.23
Hydrophobic ICL2 P 131 - G.H5 K 214 G.H5.12
Polar TM5 R 213 5x67 G.H5 Q 219 G.H5.17
Hydrophobic TM5 R 213 5x67 G.H5 Q 219 G.H5.17
Van-der-waals TM5 R 213 5x67 G.H5 Q 219 G.H5.17
Polar TM6 T 273 6x36 G.H5 N 226 G.H5.24
Hydrophobic TM6 T 273 6x36 G.H5 N 226 G.H5.24
Van-der-waals TM6 T 273 6x36 G.H5 N 226 G.H5.24
Polar H8 S 330 8x47 G.H5 E 224 G.H5.22
Hydrophobic H8 S 330 8x47 G.H5 E 224 G.H5.22
Van-der-waals H8 S 330 8x47 G.H5 E 224 G.H5.22
Hydrophobic ICL2 P 131 - G.H5 L 218 G.H5.16
Hydrophobic ICL2 L 132 - G.H5 I 217 G.H5.15
Van-der-waals ICL2 L 132 - G.H5 I 217 G.H5.15
Hydrophobic ICL2 R 133 - G.S3 V 61 G.S3.01
Hydrophobic TM3 V 128 3x54 G.H5 Y 225 G.H5.23
Van-der-waals TM3 V 128 3x54 G.H5 Y 225 G.H5.23
Hydrophobic TM5 V 207 5x61 G.H5 L 227 G.H5.25
Hydrophobic TM6 K 269 6x32 G.H5 V 228 G.H5.26
Hydrophobic TM3 V 128 3x54 G.H5 L 222 G.H5.20
Hydrophobic TM2 T 61 2x39 G.H5 Y 225 G.H5.23
Hydrophobic TM6 L 274 6x37 G.H5 L 227 G.H5.25