A2B receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XY6

RESOLUTION

3.0 Å

REFERENCE

10.1126/SCIADV.ADD3709

PUBLICATION DATE

May 3, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

42 interactions (Click to see)

LIGANDS

BAY 60-6583 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM3 R 103 3x50 G.H5 Y 374 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 Y 374 G.H5.23
Polar TM5 Q 212 5x68 G.H5 R 368 G.H5.17
Hydrophobic TM5 Q 212 5x68 G.H5 R 368 G.H5.17
Van-der-waals TM5 Q 212 5x68 G.H5 R 368 G.H5.17
Polar H8 R 295 8x48 G.H5 R 372 G.H5.21
Van-der-waals H8 R 295 8x48 G.H5 R 372 G.H5.21
Hydrophobic TM3 I 107 3x54 G.H5 L 371 G.H5.20
Polar TM3 I 107 3x54 G.H5 Q 367 G.H5.16
Polar TM5 T 216 5x72 G.H5 R 368 G.H5.17
Van-der-waals TM5 T 216 5x72 G.H5 R 368 G.H5.17
Hydrophobic TM5 T 216 5x72 G.h4s6 Y 341 G.h4s6.20
Van-der-waals TM5 T 216 5x72 G.h4s6 Y 341 G.h4s6.20
Hydrophobic ICL2 R 112 - G.S3 V 210 G.S3.01
Hydrophobic TM5 Q 212 5x68 G.H5 L 377 G.H5.26
Hydrophobic TM5 L 213 5x69 G.H5 L 377 G.H5.26
Hydrophobic ICL2 P 110 - G.H5 I 366 G.H5.15
Van-der-waals ICL2 P 110 - G.H5 I 366 G.H5.15
Hydrophobic TM3 I 107 3x54 G.H5 Y 374 G.H5.23
Ionic ICL2 R 112 - G.s2s3 D 208 G.s2s3.01
Polar ICL2 R 112 - G.s2s3 D 208 G.s2s3.01
Polar ICL2 V 117 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 V 117 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 111 - G.H5 R 363 G.H5.12
Hydrophobic ICL2 P 110 - G.H5 R 363 G.H5.12
Hydrophobic ICL2 Y 113 - G.H5 H 370 G.H5.19
Hydrophobic TM5 Q 212 5x68 G.H5 L 371 G.H5.20
Hydrophobic ICL2 P 110 - G.H5 Q 367 G.H5.16
Hydrophobic TM5 A 209 5x65 G.H5 L 371 G.H5.20
Hydrophobic ICL2 L 111 - G.H5 I 366 G.H5.15
Polar TM3 A 106 3x53 G.H5 H 370 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 H 370 G.H5.19
Van-der-waals TM3 A 106 3x53 G.H5 H 370 G.H5.19
Hydrophobic TM6 S 235 6x36 G.H5 L 376 G.H5.25
Hydrophobic ICL2 L 111 - G.H5 C 362 G.H5.11
Hydrophobic TM5 V 208 5x64 G.H5 Q 367 G.H5.16
Van-der-waals TM5 V 208 5x64 G.H5 Q 367 G.H5.16
Polar ICL2 L 111 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 L 111 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 L 111 - G.S1 H 34 G.S1.02
Hydrophobic ICL2 S 115 - G.hns1 A 32 G.hns1.03
Van-der-waals ICL2 S 115 - G.hns1 A 32 G.hns1.03
Hydrophobic TM5 I 205 5x61 G.H5 L 376 G.H5.25
Hydrophobic ICL2 P 110 - G.H5 H 370 G.H5.19
Polar TM5 Q 212 5x68 G.H5 Q 367 G.H5.16
Van-der-waals TM5 Q 212 5x68 G.H5 Q 367 G.H5.16
Hydrophobic ICL2 L 111 - G.H5 F 359 G.H5.08
Van-der-waals ICL2 L 111 - G.H5 F 359 G.H5.08
Polar TM5 Q 212 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 Q 212 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM6 R 228 6x29 G.H5 L 377 G.H5.26