GPCRdb

Refined structure (6LFO) of G_i1 - CXCR2

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2024-02-01

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Structure

GPCR

Gα

Gβ

Gγ
Model

AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 230 from structure (65.0%), 124 from model (35.0%)
Residue sidechains - 218 from structure (61.6%), 136 from model (38.4%)

Showing 1 to 354 of 354 entries

Search:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from
	:

Segment	Seq.num.	AA	CGN#	Backbone from	Sidechain from

G.HN	1	M	G.HN.01	AF2	AF2
G.HN	2	G	G.HN.02	AF2	AF2
G.HN	3	C	G.HN.09	Structure	Structure
G.HN	4	T	G.HN.10	Structure	Structure
G.HN	5	L	G.HN.11	Structure	Structure
G.HN	6	S	G.HN.30	Structure	Structure
G.HN	7	A	G.HN.31	Structure	Structure
G.HN	8	E	G.HN.32	Structure	Structure
G.HN	9	D	G.HN.33	Structure	Structure
G.HN	10	K	G.HN.34	Structure	Structure
G.HN	11	A	G.HN.35	Structure	Structure
G.HN	12	A	G.HN.36	Structure	Structure
G.HN	13	V	G.HN.37	Structure	Structure
G.HN	14	E	G.HN.38	Structure	Structure
G.HN	15	R	G.HN.39	Structure	Structure
G.HN	16	S	G.HN.40	Structure	Structure
G.HN	17	K	G.HN.41	Structure	Structure
G.HN	18	M	G.HN.42	Structure	Structure
G.HN	19	I	G.HN.43	Structure	Structure
G.HN	20	D	G.HN.44	Structure	Structure
G.HN	21	R	G.HN.45	Structure	Structure
G.HN	22	N	G.HN.46	Structure	Structure
G.HN	23	L	G.HN.47	Structure	Structure
G.HN	24	R	G.HN.48	Structure	Structure
G.HN	25	E	G.HN.49	Structure	AF2
G.HN	26	D	G.HN.50	Structure	Structure
G.HN	27	G	G.HN.51	Structure	Structure
G.HN	28	E	G.HN.52	Structure	Structure
G.HN	29	K	G.HN.53	Structure	Structure
G.hns1	30	A	G.hns1.01	Structure	Structure
G.hns1	31	A	G.hns1.02	Structure	Structure
G.hns1	32	R	G.hns1.03	Structure	Structure
G.S1	33	E	G.S1.01	Structure	Structure
G.S1	34	V	G.S1.02	Structure	Structure
G.S1	35	K	G.S1.03	Structure	Structure
G.S1	36	L	G.S1.04	Structure	Structure
G.S1	37	L	G.S1.05	Structure	Structure
G.S1	38	L	G.S1.06	Structure	Structure
G.S1	39	L	G.S1.07	Structure	Structure
G.s1h1	40	G	G.s1h1.01	Structure	Structure
G.s1h1	41	A	G.s1h1.02	Structure	Structure
G.s1h1	42	G	G.s1h1.03	Structure	Structure
G.s1h1	43	E	G.s1h1.04	Structure	Structure
G.s1h1	44	S	G.s1h1.05	Structure	Structure
G.s1h1	45	G	G.s1h1.06	Structure	Structure
G.H1	46	K	G.H1.01	Structure	Structure
G.H1	47	S	G.H1.02	Structure	Structure
G.H1	48	T	G.H1.03	Structure	Structure
G.H1	49	I	G.H1.04	Structure	Structure
G.H1	50	V	G.H1.05	Structure	Structure
G.H1	51	K	G.H1.06	Structure	AF2
G.H1	52	Q	G.H1.07	Structure	Structure
G.H1	53	M	G.H1.08	Structure	Structure
G.H1	54	K	G.H1.09	Structure	AF2
G.H1	55	I	G.H1.10	Structure	Structure
G.H1	56	I	G.H1.11	Structure	Structure
G.H1	57	H	G.H1.12	AF2	AF2
G.h1ha	58	E	G.h1ha.01	AF2	AF2
G.h1ha	59	A	G.h1ha.02	AF2	AF2
G.h1ha	60	G	G.h1ha.03	AF2	AF2
G.h1ha	61	Y	G.h1ha.04	AF2	AF2
G.h1ha	62	S	G.h1ha.05	AF2	AF2
H.HA	63	E	H.HA.01	AF2	AF2
H.HA	64	E	H.HA.02	AF2	AF2
H.HA	65	E	H.HA.03	AF2	AF2
H.HA	66	C	H.HA.04	AF2	AF2
H.HA	67	K	H.HA.05	AF2	AF2
H.HA	68	Q	H.HA.06	AF2	AF2
H.HA	69	Y	H.HA.07	AF2	AF2
H.HA	70	K	H.HA.08	AF2	AF2
H.HA	71	A	H.HA.09	AF2	AF2
H.HA	72	V	H.HA.10	AF2	AF2
H.HA	73	V	H.HA.11	AF2	AF2
H.HA	74	Y	H.HA.12	AF2	AF2
H.HA	75	S	H.HA.13	AF2	AF2
H.HA	76	N	H.HA.14	AF2	AF2
H.HA	77	T	H.HA.15	AF2	AF2
H.HA	78	I	H.HA.16	AF2	AF2
H.HA	79	Q	H.HA.17	AF2	AF2
H.HA	80	S	H.HA.18	AF2	AF2
H.HA	81	I	H.HA.19	AF2	AF2
H.HA	82	I	H.HA.20	AF2	AF2
H.HA	83	A	H.HA.21	AF2	AF2
H.HA	84	I	H.HA.22	AF2	AF2
H.HA	85	I	H.HA.23	AF2	AF2
H.HA	86	R	H.HA.24	AF2	AF2
H.HA	87	A	H.HA.25	AF2	AF2
H.HA	88	M	H.HA.26	AF2	AF2
H.HA	89	G	H.HA.27	AF2	AF2
H.HA	90	R	H.HA.28	AF2	AF2
H.HA	91	L	H.HA.29	AF2	AF2
H.hahb	92	K	H.hahb.01	AF2	AF2
H.hahb	93	I	H.hahb.04	AF2	AF2
H.hahb	94	D	H.hahb.05	AF2	AF2
H.hahb	95	F	H.hahb.06	AF2	AF2
H.hahb	96	G	H.hahb.07	AF2	AF2
H.hahb	97	D	H.hahb.08	AF2	AF2
H.hahb	98	S	H.hahb.09	AF2	AF2
H.HB	99	A	H.HB.01	AF2	AF2
H.HB	100	R	H.HB.02	AF2	AF2
H.HB	101	A	H.HB.03	AF2	AF2
H.HB	102	D	H.HB.04	AF2	AF2
H.HB	103	D	H.HB.05	AF2	AF2
H.HB	104	A	H.HB.06	AF2	AF2
H.HB	105	R	H.HB.07	AF2	AF2
H.HB	106	Q	H.HB.08	AF2	AF2
H.HB	107	L	H.HB.09	AF2	AF2
H.HB	108	F	H.HB.10	AF2	AF2
H.HB	109	V	H.HB.11	AF2	AF2
H.HB	110	L	H.HB.12	AF2	AF2
H.HB	111	A	H.HB.13	AF2	AF2
H.HB	112	G	H.HB.14	AF2	AF2
H.hbhc	113	A	H.hbhc.01	AF2	AF2
H.hbhc	114	A	H.hbhc.02	AF2	AF2
H.hbhc	115	E	H.hbhc.03	AF2	AF2
H.hbhc	116	E	H.hbhc.04	AF2	AF2
H.hbhc	117	G	H.hbhc.12	AF2	AF2
H.hbhc	118	F	H.hbhc.13	AF2	AF2
H.hbhc	119	M	H.hbhc.14	AF2	AF2
H.hbhc	120	T	H.hbhc.15	AF2	AF2
H.HC	121	A	H.HC.01	AF2	AF2
H.HC	122	E	H.HC.02	AF2	AF2
H.HC	123	L	H.HC.03	AF2	AF2
H.HC	124	A	H.HC.04	AF2	AF2
H.HC	125	G	H.HC.05	AF2	AF2
H.HC	126	V	H.HC.06	AF2	AF2
H.HC	127	I	H.HC.07	AF2	AF2
H.HC	128	K	H.HC.08	AF2	AF2
H.HC	129	R	H.HC.09	AF2	AF2
H.HC	130	L	H.HC.10	AF2	AF2
H.HC	131	W	H.HC.11	AF2	AF2
H.HC	132	K	H.HC.12	AF2	AF2
H.hchd	133	D	H.hchd.01	AF2	AF2
H.HD	134	S	H.HD.01	AF2	AF2
H.HD	135	G	H.HD.02	AF2	AF2
H.HD	136	V	H.HD.03	AF2	AF2
H.HD	137	Q	H.HD.04	AF2	AF2
H.HD	138	A	H.HD.05	AF2	AF2
H.HD	139	C	H.HD.06	AF2	AF2
H.HD	140	F	H.HD.07	AF2	AF2
H.HD	141	N	H.HD.08	AF2	AF2
H.HD	142	R	H.HD.09	AF2	AF2
H.HD	143	S	H.HD.10	AF2	AF2
H.HD	144	R	H.HD.11	AF2	AF2
H.HD	145	E	H.HD.12	AF2	AF2
H.hdhe	146	Y	H.hdhe.01	AF2	AF2
H.hdhe	147	Q	H.hdhe.02	AF2	AF2
H.hdhe	148	L	H.hdhe.03	AF2	AF2
H.hdhe	149	N	H.hdhe.04	AF2	AF2
H.hdhe	150	D	H.hdhe.05	AF2	AF2
H.HE	151	S	H.HE.01	AF2	AF2
H.HE	152	A	H.HE.02	AF2	AF2
H.HE	153	A	H.HE.03	AF2	AF2
H.HE	154	Y	H.HE.04	AF2	AF2
H.HE	155	Y	H.HE.05	AF2	AF2
H.HE	156	L	H.HE.06	AF2	AF2
H.HE	157	N	H.HE.07	AF2	AF2
H.HE	158	D	H.HE.08	AF2	AF2
H.HE	159	L	H.HE.09	AF2	AF2
H.HE	160	D	H.HE.10	AF2	AF2
H.HE	161	R	H.HE.11	AF2	AF2
H.HE	162	I	H.HE.12	AF2	AF2
H.HE	163	A	H.HE.13	AF2	AF2
H.hehf	164	Q	H.hehf.01	AF2	AF2
H.hehf	165	P	H.hehf.02	AF2	AF2
H.hehf	166	N	H.hehf.03	AF2	AF2
H.hehf	167	Y	H.hehf.04	AF2	AF2
H.hehf	168	I	H.hehf.05	AF2	AF2
H.hehf	169	P	H.hehf.06	AF2	AF2
H.hehf	170	T	H.hehf.07	AF2	AF2
H.HF	171	Q	H.HF.01	AF2	AF2
H.HF	172	Q	H.HF.02	AF2	AF2
H.HF	173	D	H.HF.03	AF2	AF2
H.HF	174	V	H.HF.04	AF2	AF2
H.HF	175	L	H.HF.05	AF2	AF2
H.HF	176	R	H.HF.06	AF2	AF2
G.hfs2	177	T	G.hfs2.01	AF2	AF2
G.hfs2	178	R	G.hfs2.02	AF2	AF2
G.hfs2	179	V	G.hfs2.03	Structure	Structure
G.hfs2	180	K	G.hfs2.04	Structure	Structure
G.hfs2	181	T	G.hfs2.05	Structure	Structure
G.hfs2	182	T	G.hfs2.06	Structure	Structure
G.hfs2	183	G	G.hfs2.07	Structure	Structure
G.S2	184	I	G.S2.01	Structure	Structure
G.S2	185	V	G.S2.02	Structure	Structure
G.S2	186	E	G.S2.03	Structure	Structure
G.S2	187	T	G.S2.04	Structure	Structure
G.S2	188	H	G.S2.05	Structure	Structure
G.S2	189	F	G.S2.06	Structure	Structure
G.S2	190	T	G.S2.07	Structure	Structure
G.S2	191	F	G.S2.08	Structure	Structure
G.s2s3	192	K	G.s2s3.01	Structure	Structure
G.s2s3	193	D	G.s2s3.02	Structure	AF2
G.S3	194	L	G.S3.01	Structure	Structure
G.S3	195	H	G.S3.02	Structure	Structure
G.S3	196	F	G.S3.03	Structure	Structure
G.S3	197	K	G.S3.04	Structure	Structure
G.S3	198	M	G.S3.05	Structure	Structure
G.S3	199	F	G.S3.06	Structure	Structure
G.S3	200	D	G.S3.07	Structure	Structure
G.S3	201	V	G.S3.08	Structure	Structure
G.s3h2	202	G	G.s3h2.01	Structure	Structure
G.s3h2	203	G	G.s3h2.02	Structure	Structure
G.s3h2	204	Q	G.s3h2.03	Structure	Structure
G.H2	205	R	G.H2.01	Structure	AF2
G.H2	206	S	G.H2.02	Structure	Structure
G.H2	207	E	G.H2.03	Structure	Structure
G.H2	208	R	G.H2.04	Structure	Structure
G.H2	209	K	G.H2.05	Structure	Structure
G.H2	210	K	G.H2.06	Structure	Structure
G.H2	211	W	G.H2.07	Structure	Structure
G.H2	212	I	G.H2.08	Structure	Structure
G.H2	213	H	G.H2.09	Structure	Structure
G.H2	214	C	G.H2.10	Structure	Structure
G.h2s4	215	F	G.h2s4.01	Structure	Structure
G.h2s4	216	E	G.h2s4.02	Structure	Structure
G.h2s4	217	G	G.h2s4.03	Structure	Structure
G.h2s4	218	V	G.h2s4.04	Structure	Structure
G.h2s4	219	T	G.h2s4.05	Structure	Structure
G.S4	220	A	G.S4.01	Structure	Structure
G.S4	221	I	G.S4.02	Structure	Structure
G.S4	222	I	G.S4.03	Structure	Structure
G.S4	223	F	G.S4.04	Structure	Structure
G.S4	224	C	G.S4.05	Structure	Structure
G.S4	225	V	G.S4.06	Structure	Structure
G.S4	226	A	G.S4.07	Structure	Structure
G.s4h3	227	L	G.s4h3.01	Structure	Structure
G.s4h3	228	S	G.s4h3.02	Structure	Structure
G.s4h3	229	D	G.s4h3.03	Structure	Structure
G.s4h3	230	Y	G.s4h3.04	Structure	Structure
G.s4h3	231	D	G.s4h3.05	Structure	Structure
G.s4h3	232	L	G.s4h3.06	Structure	Structure
G.s4h3	233	V	G.s4h3.07	Structure	Structure
G.s4h3	234	L	G.s4h3.08	Structure	Structure
G.s4h3	235	A	G.s4h3.09	Structure	Structure
G.s4h3	236	E	G.s4h3.10	Structure	Structure
G.s4h3	237	D	G.s4h3.11	Structure	Structure
G.s4h3	238	E	G.s4h3.12	Structure	Structure
G.s4h3	239	E	G.s4h3.13	Structure	Structure
G.s4h3	240	M	G.s4h3.14	Structure	Structure
G.s4h3	241	N	G.s4h3.15	Structure	Structure
G.H3	242	R	G.H3.01	Structure	Structure
G.H3	243	M	G.H3.02	Structure	Structure
G.H3	244	H	G.H3.03	Structure	Structure
G.H3	245	E	G.H3.04	Structure	Structure
G.H3	246	S	G.H3.05	Structure	Structure
G.H3	247	M	G.H3.06	Structure	Structure
G.H3	248	K	G.H3.07	Structure	Structure
G.H3	249	L	G.H3.08	Structure	Structure
G.H3	250	F	G.H3.09	Structure	Structure
G.H3	251	D	G.H3.10	Structure	Structure
G.H3	252	S	G.H3.11	Structure	Structure
G.H3	253	I	G.H3.12	Structure	Structure
G.H3	254	C	G.H3.13	Structure	Structure
G.H3	255	N	G.H3.14	Structure	Structure
G.H3	256	N	G.H3.15	Structure	Structure
G.H3	257	K	G.H3.16	Structure	Structure
G.H3	258	W	G.H3.17	Structure	Structure
G.H3	259	F	G.H3.18	Structure	Structure
G.h3s5	260	T	G.h3s5.01	Structure	Structure
G.h3s5	261	D	G.h3s5.02	Structure	AF2
G.h3s5	262	T	G.h3s5.03	Structure	Structure
G.S5	263	S	G.S5.01	Structure	Structure
G.S5	264	I	G.S5.02	Structure	Structure
G.S5	265	I	G.S5.03	Structure	Structure
G.S5	266	L	G.S5.04	Structure	Structure
G.S5	267	F	G.S5.05	Structure	Structure
G.S5	268	L	G.S5.06	Structure	Structure
G.S5	269	N	G.S5.07	Structure	Structure
G.s5hg	270	K	G.s5hg.01	Structure	Structure
G.HG	271	K	G.HG.01	Structure	Structure
G.HG	272	D	G.HG.02	Structure	AF2
G.HG	273	L	G.HG.03	Structure	Structure
G.HG	274	F	G.HG.04	Structure	Structure
G.HG	275	E	G.HG.05	Structure	Structure
G.HG	276	E	G.HG.06	Structure	Structure
G.HG	277	K	G.HG.07	Structure	Structure
G.HG	278	I	G.HG.08	Structure	Structure
G.HG	279	K	G.HG.09	Structure	AF2
G.HG	280	K	G.HG.12	Structure	AF2
G.HG	281	S	G.HG.13	Structure	Structure
G.HG	282	P	G.HG.14	Structure	Structure
G.HG	283	L	G.HG.15	Structure	Structure
G.HG	284	T	G.HG.16	Structure	Structure
G.HG	285	I	G.HG.17	Structure	Structure
G.hgh4	286	C	G.hgh4.01	Structure	Structure
G.hgh4	287	Y	G.hgh4.02	Structure	Structure
G.hgh4	288	P	G.hgh4.03	Structure	Structure
G.hgh4	289	E	G.hgh4.04	Structure	AF2
G.hgh4	290	Y	G.hgh4.05	Structure	Structure
G.hgh4	291	A	G.hgh4.06	Structure	Structure
G.hgh4	292	G	G.hgh4.07	Structure	Structure
G.hgh4	293	S	G.hgh4.08	Structure	Structure
G.H4	294	N	G.H4.01	Structure	Structure
G.H4	295	T	G.H4.02	Structure	AF2
G.H4	296	Y	G.H4.03	Structure	Structure
G.H4	297	E	G.H4.04	Structure	AF2
G.H4	298	E	G.H4.05	Structure	Structure
G.H4	299	A	G.H4.06	Structure	Structure
G.H4	300	A	G.H4.07	Structure	Structure
G.H4	301	A	G.H4.08	Structure	Structure
G.H4	302	Y	G.H4.10	Structure	Structure
G.H4	303	I	G.H4.11	Structure	Structure
G.H4	304	Q	G.H4.12	Structure	Structure
G.H4	305	C	G.H4.13	Structure	Structure
G.H4	306	Q	G.H4.14	Structure	Structure
G.H4	307	F	G.H4.15	Structure	Structure
G.H4	308	E	G.H4.16	Structure	Structure
G.H4	309	D	G.H4.17	Structure	Structure
G.h4s6	310	L	G.h4s6.01	Structure	Structure
G.h4s6	311	N	G.h4s6.02	Structure	Structure
G.h4s6	312	K	G.h4s6.03	Structure	Structure
G.h4s6	313	R	G.h4s6.04	Structure	Structure
G.h4s6	314	K	G.h4s6.08	Structure	Structure
G.h4s6	315	D	G.h4s6.09	Structure	Structure
G.h4s6	316	T	G.h4s6.10	Structure	Structure
G.h4s6	317	K	G.h4s6.11	Structure	Structure
G.h4s6	318	E	G.h4s6.12	Structure	Structure
G.S6	319	I	G.S6.01	Structure	Structure
G.S6	320	Y	G.S6.02	Structure	Structure
G.S6	321	T	G.S6.03	Structure	Structure
G.S6	322	H	G.S6.04	Structure	Structure
G.S6	323	F	G.S6.05	Structure	Structure
G.s6h5	324	T	G.s6h5.01	Structure	Structure
G.s6h5	325	C	G.s6h5.02	Structure	Structure
G.s6h5	326	A	G.s6h5.03	Structure	Structure
G.s6h5	327	T	G.s6h5.04	Structure	Structure
G.s6h5	328	D	G.s6h5.05	Structure	Structure
G.H5	329	T	G.H5.01	Structure	Structure
G.H5	330	K	G.H5.02	Structure	Structure
G.H5	331	N	G.H5.03	Structure	Structure
G.H5	332	V	G.H5.04	Structure	Structure
G.H5	333	Q	G.H5.05	Structure	Structure
G.H5	334	F	G.H5.06	Structure	Structure
G.H5	335	V	G.H5.07	Structure	Structure
G.H5	336	F	G.H5.08	Structure	Structure
G.H5	337	D	G.H5.09	Structure	Structure
G.H5	338	A	G.H5.10	Structure	Structure
G.H5	339	V	G.H5.11	Structure	Structure
G.H5	340	T	G.H5.12	Structure	Structure
G.H5	341	D	G.H5.13	Structure	Structure
G.H5	342	V	G.H5.14	Structure	Structure
G.H5	343	I	G.H5.15	Structure	Structure
G.H5	344	I	G.H5.16	Structure	Structure
G.H5	345	K	G.H5.17	Structure	Structure
G.H5	346	N	G.H5.18	Structure	Structure
G.H5	347	N	G.H5.19	Structure	Structure
G.H5	348	L	G.H5.20	Structure	Structure
G.H5	349	K	G.H5.21	Structure	Structure
G.H5	350	D	G.H5.22	Structure	Structure
G.H5	351	C	G.H5.23	Structure	Structure
G.H5	352	G	G.H5.24	Structure	Structure
G.H5	353	L	G.H5.25	Structure	Structure
G.H5	354	F	G.H5.26	Structure	Structure

REFINED GPCR RESIDUES

Residue backbones - 307 from structure (89.8%), 35 from model (10.2%)
Residue sidechains - 306 from structure (89.5%), 36 from model (10.5%)

Showing 1 to 342 of 342 entries

Search:

Segment	Seq.num.	AA	GPCRdb#	Backbone from	Sidechain from

N-term	1	M	-	AF2	AF2
N-term	2	E	-	AF2	AF2
N-term	3	D	-	AF2	AF2
N-term	4	F	-	AF2	AF2
N-term	5	N	-	AF2	AF2
N-term	6	M	-	AF2	AF2
N-term	7	E	-	AF2	AF2
N-term	8	S	-	AF2	AF2
N-term	9	D	-	AF2	AF2
N-term	10	S	-	AF2	AF2
N-term	11	F	-	AF2	AF2
N-term	12	E	-	AF2	AF2
N-term	13	D	-	AF2	AF2
N-term	14	F	-	AF2	AF2
N-term	15	W	-	AF2	AF2
N-term	16	K	-	AF2	AF2
N-term	17	G	-	AF2	AF2
N-term	18	E	-	AF2	AF2
N-term	19	D	-	AF2	AF2
N-term	20	L	-	AF2	AF2
N-term	21	S	-	AF2	AF2
N-term	22	N	-	AF2	AF2
N-term	23	Y	-	AF2	AF2
N-term	24	S	-	AF2	AF2
N-term	25	Y	-	AF2	AF2
N-term	26	S	-	Structure	Structure
N-term	27	S	-	Structure	Structure
N-term	28	T	-	Structure	Structure
N-term	29	L	-	Structure	Structure
N-term	30	P	-	Structure	Structure
N-term	31	P	-	Structure	Structure
N-term	32	F	-	Structure	Structure
N-term	33	L	-	Structure	Structure
N-term	34	L	-	Structure	Structure
N-term	35	D	-	Structure	Structure
N-term	36	A	-	Structure	Structure
N-term	37	A	-	Structure	Structure
N-term	38	P	-	Structure	Structure
N-term	39	C	-	Structure	Structure
N-term	40	E	-	Structure	Structure
N-term	41	P	-	Structure	Structure
N-term	42	E	-	Structure	Structure
N-term	43	S	-	Structure	Structure
N-term	44	L	-	Structure	Structure
TM1	45	E	1.29x29	Structure	Structure
TM1	46	I	1.30x30	Structure	Structure
TM1	47	N	1.31x31	Structure	Structure
TM1	48	K	1.32x32	Structure	Structure
TM1	49	Y	1.33x33	Structure	Structure
TM1	50	F	1.34x34	Structure	Structure
TM1	51	V	1.35x35	Structure	Structure
TM1	52	V	1.36x36	Structure	Structure
TM1	53	I	1.37x37	Structure	Structure
TM1	54	I	1.38x38	Structure	Structure
TM1	55	Y	1.39x39	Structure	Structure
TM1	56	A	1.40x40	Structure	Structure
TM1	57	L	1.41x41	Structure	Structure
TM1	58	V	1.42x42	Structure	Structure
TM1	59	F	1.43x43	Structure	Structure
TM1	60	L	1.44x44	Structure	Structure
TM1	61	L	1.45x45	Structure	Structure
TM1	62	S	1.46x46	Structure	Structure
TM1	63	L	1.47x47	Structure	Structure
TM1	64	L	1.48x48	Structure	Structure
TM1	65	G	1.49x49	Structure	Structure
TM1	66	N	1.50x50	Structure	Structure
TM1	67	S	1.51x51	Structure	Structure
TM1	68	L	1.52x52	Structure	Structure
TM1	69	V	1.53x53	Structure	Structure
TM1	70	M	1.54x54	Structure	Structure
TM1	71	L	1.55x55	Structure	Structure
TM1	72	V	1.56x56	Structure	Structure
TM1	73	I	1.57x57	Structure	Structure
TM1	74	L	1.58x58	Structure	Structure
TM1	75	Y	1.59x59	Structure	Structure
TM1	76	S	1.60x60	Structure	Structure
ICL1	77	R	12.48x48	Structure	Structure
ICL1	78	V	12.49x49	Structure	Structure
ICL1	79	G	12.50x50	Structure	Structure
ICL1	80	R	12.51x51	Structure	Structure
TM2	81	S	2.37x37	Structure	Structure
TM2	82	V	2.38x38	Structure	Structure
TM2	83	T	2.39x39	Structure	Structure
TM2	84	D	2.40x40	Structure	Structure
TM2	85	V	2.41x41	Structure	Structure
TM2	86	Y	2.42x42	Structure	Structure
TM2	87	L	2.43x43	Structure	Structure
TM2	88	L	2.44x44	Structure	Structure
TM2	89	N	2.45x45	Structure	Structure
TM2	90	L	2.46x46	Structure	Structure
TM2	91	A	2.47x47	Structure	Structure
TM2	92	L	2.48x48	Structure	Structure
TM2	93	A	2.49x49	Structure	Structure
TM2	94	D	2.50x50	Structure	Structure
TM2	95	L	2.51x51	Structure	Structure
TM2	96	L	2.52x52	Structure	Structure
TM2	97	F	2.53x53	Structure	Structure
TM2	98	A	2.54x54	Structure	Structure
TM2	99	L	2.55x55	Structure	Structure
TM2	100	T	2.56x56	Structure	Structure
TM2	101	L	2.57x57	Structure	Structure
TM2	102	P	2.58x58	Structure	Structure
TM2	103	I	2.59x59	Structure	Structure
TM2	104	W	2.60x60	Structure	Structure
TM2	105	A	2.61x61	Structure	Structure
TM2	106	A	2.62x62	Structure	Structure
TM2	107	S	2.63x63	Structure	Structure
TM2	108	K	2.64x64	Structure	Structure
TM2	109	V	2.65x65	Structure	Structure
TM2	110	N	2.66x66	Structure	Structure
ECL1	111	G	23.49x49	Structure	Structure
ECL1	112	W	23.50x50	Structure	Structure
ECL1	113	I	23.51x51	Structure	Structure
ECL1	114	F	23.52x52	Structure	Structure
TM3	115	G	3.21x21	Structure	Structure
TM3	116	T	3.22x22	Structure	Structure
TM3	117	F	3.23x23	Structure	Structure
TM3	118	L	3.24x24	Structure	Structure
TM3	119	C	3.25x25	Structure	Structure
TM3	120	K	3.26x26	Structure	AF2
TM3	121	V	3.27x27	Structure	Structure
TM3	122	V	3.28x28	Structure	Structure
TM3	123	S	3.29x29	Structure	Structure
TM3	124	L	3.30x30	Structure	Structure
TM3	125	L	3.31x31	Structure	Structure
TM3	126	K	3.32x32	Structure	Structure
TM3	127	E	3.33x33	Structure	Structure
TM3	128	V	3.34x34	Structure	Structure
TM3	129	N	3.35x35	Structure	Structure
TM3	130	F	3.36x36	Structure	Structure
TM3	131	Y	3.37x37	Structure	Structure
TM3	132	S	3.38x38	Structure	Structure
TM3	133	G	3.39x39	Structure	Structure
TM3	134	I	3.40x40	Structure	Structure
TM3	135	L	3.41x41	Structure	Structure
TM3	136	L	3.42x42	Structure	Structure
TM3	137	L	3.43x43	Structure	Structure
TM3	138	A	3.44x44	Structure	Structure
TM3	139	C	3.45x45	Structure	Structure
TM3	140	I	3.46x46	Structure	Structure
TM3	141	S	3.47x47	Structure	Structure
TM3	142	V	3.48x48	Structure	Structure
TM3	143	D	3.49x49	Structure	Structure
TM3	144	R	3.50x50	Structure	Structure
TM3	145	Y	3.51x51	Structure	Structure
TM3	146	L	3.52x52	Structure	Structure
TM3	147	A	3.53x53	Structure	Structure
TM3	148	I	3.54x54	Structure	Structure
TM3	149	V	3.55x55	Structure	Structure
TM3	150	H	3.56x56	Structure	Structure
ICL2	151	A	34.50x50	Structure	Structure
ICL2	152	T	34.51x51	Structure	Structure
ICL2	153	R	34.52x52	Structure	Structure
ICL2	154	T	34.53x53	Structure	Structure
ICL2	155	L	34.54x54	Structure	Structure
ICL2	156	T	34.55x55	Structure	Structure
ICL2	157	Q	34.56x56	Structure	Structure
ICL2	158	K	34.57x57	Structure	Structure
ICL2	159	R	34.58x58	Structure	Structure
ICL2	160	Y	34.59x59	Structure	Structure
TM4	161	L	4.41x41	Structure	Structure
TM4	162	V	4.42x42	Structure	Structure
TM4	163	K	4.43x43	Structure	Structure
TM4	164	F	4.44x44	Structure	Structure
TM4	165	I	4.45x45	Structure	Structure
TM4	166	C	4.46x46	Structure	Structure
TM4	167	L	4.47x47	Structure	Structure
TM4	168	S	4.48x48	Structure	Structure
TM4	169	I	4.49x49	Structure	Structure
TM4	170	W	4.50x50	Structure	Structure
TM4	171	G	4.51x51	Structure	Structure
TM4	172	L	4.52x52	Structure	Structure
TM4	173	S	4.53x53	Structure	Structure
TM4	174	L	4.54x54	Structure	Structure
TM4	175	L	4.55x55	Structure	Structure
TM4	176	L	4.56x56	Structure	Structure
TM4	177	A	4.57x57	Structure	Structure
TM4	178	L	4.58x59	Structure	Structure
TM4	179	P	4.59x60	Structure	Structure
TM4	180	V	4.60x61	Structure	Structure
TM4	181	L	4.61x62	Structure	Structure
TM4	182	L	4.62x63	Structure	Structure
TM4	183	F	4.63x64	Structure	Structure
TM4	184	R	4.64x65	Structure	Structure
ECL2	185	R	-	Structure	Structure
ECL2	186	T	-	Structure	Structure
ECL2	187	V	-	Structure	Structure
ECL2	188	Y	-	Structure	Structure
ECL2	189	S	-	Structure	Structure
ECL2	190	S	-	Structure	Structure
ECL2	191	N	-	Structure	Structure
ECL2	192	V	-	Structure	Structure
ECL2	193	S	-	Structure	Structure
ECL2	194	P	-	Structure	Structure
ECL2	195	A	-	Structure	Structure
ECL2	196	C	45.50x50	Structure	Structure
ECL2	197	Y	45.51x51	Structure	Structure
ECL2	198	E	45.52x52	Structure	Structure
ECL2	199	D	-	Structure	Structure
ECL2	200	M	-	Structure	Structure
ECL2	201	G	-	Structure	Structure
ECL2	202	N	-	Structure	Structure
TM5	203	N	5.30x31	Structure	Structure
TM5	204	T	5.31x32	Structure	Structure
TM5	205	A	5.32x33	Structure	Structure
TM5	206	N	5.33x34	Structure	Structure
TM5	207	W	5.34x35	Structure	Structure
TM5	208	R	5.35x36	Structure	Structure
TM5	209	M	5.36x37	Structure	Structure
TM5	210	L	5.37x38	Structure	Structure
TM5	211	L	5.38x39	Structure	Structure
TM5	212	R	5.39x40	Structure	Structure
TM5	213	I	5.40x41	Structure	Structure
TM5	214	L	5.41x42	Structure	Structure
TM5	215	P	5.42x43	Structure	Structure
TM5	216	Q	5.43x44	Structure	Structure
TM5	217	S	5.44x45	Structure	Structure
TM5	218	F	5.45x46	Structure	Structure
TM5	219	G	5.46x461	Structure	Structure
TM5	220	F	5.47x47	Structure	Structure
TM5	221	I	5.48x48	Structure	Structure
TM5	222	V	5.49x49	Structure	Structure
TM5	223	P	5.50x50	Structure	Structure
TM5	224	L	5.51x51	Structure	Structure
TM5	225	L	5.52x52	Structure	Structure
TM5	226	I	5.53x53	Structure	Structure
TM5	227	M	5.54x54	Structure	Structure
TM5	228	L	5.55x55	Structure	Structure
TM5	229	F	5.56x56	Structure	Structure
TM5	230	C	5.57x57	Structure	Structure
TM5	231	Y	5.58x58	Structure	Structure
TM5	232	G	5.59x59	Structure	Structure
TM5	233	F	5.60x60	Structure	Structure
TM5	234	T	5.61x61	Structure	Structure
TM5	235	L	5.62x62	Structure	Structure
TM5	236	R	5.63x63	Structure	Structure
TM5	237	T	5.64x64	Structure	Structure
TM5	238	L	5.65x65	Structure	Structure
TM5	239	F	5.66x66	Structure	Structure
TM5	240	K	5.67x67	Structure	Structure
TM5	241	A	5.68x68	Structure	Structure
ICL3	242	H	-	Structure	Structure
ICL3	243	M	-	Structure	Structure
ICL3	244	G	-	Structure	Structure
TM6	245	Q	6.29x29	Structure	Structure
TM6	246	K	6.30x30	Structure	Structure
TM6	247	H	6.31x31	Structure	Structure
TM6	248	R	6.32x32	Structure	Structure
TM6	249	A	6.33x33	Structure	Structure
TM6	250	M	6.34x34	Structure	Structure
TM6	251	R	6.35x35	Structure	Structure
TM6	252	V	6.36x36	Structure	Structure
TM6	253	I	6.37x37	Structure	Structure
TM6	254	F	6.38x38	Structure	Structure
TM6	255	A	6.39x39	Structure	Structure
TM6	256	V	6.40x40	Structure	Structure
TM6	257	V	6.41x41	Structure	Structure
TM6	258	L	6.42x42	Structure	Structure
TM6	259	I	6.43x43	Structure	Structure
TM6	260	F	6.44x44	Structure	Structure
TM6	261	L	6.45x45	Structure	Structure
TM6	262	L	6.46x46	Structure	Structure
TM6	263	C	6.47x47	Structure	Structure
TM6	264	W	6.48x48	Structure	Structure
TM6	265	L	6.49x49	Structure	Structure
TM6	266	P	6.50x50	Structure	Structure
TM6	267	Y	6.51x51	Structure	Structure
TM6	268	N	6.52x52	Structure	Structure
TM6	269	L	6.53x53	Structure	Structure
TM6	270	V	6.54x54	Structure	Structure
TM6	271	L	6.55x55	Structure	Structure
TM6	272	L	6.56x56	Structure	Structure
TM6	273	A	6.57x57	Structure	Structure
TM6	274	D	6.58x58	Structure	Structure
TM6	275	T	6.59x59	Structure	Structure
TM6	276	L	6.60x60	Structure	Structure
TM6	277	M	6.61x61	Structure	Structure
TM6	278	R	6.62x62	Structure	Structure
TM6	279	T	6.63x63	Structure	Structure
TM6	280	Q	6.64x64	Structure	Structure
ECL3	281	V	-	Structure	Structure
ECL3	282	I	-	Structure	Structure
ECL3	283	Q	-	Structure	Structure
ECL3	284	E	-	Structure	Structure
TM7	285	T	7.24x23	Structure	Structure
TM7	286	C	7.25x24	Structure	Structure
TM7	287	E	7.26x25	Structure	Structure
TM7	288	R	7.27x26	Structure	Structure
TM7	289	R	7.28x27	Structure	Structure
TM7	290	N	7.29x28	Structure	Structure
TM7	291	H	7.30x29	Structure	Structure
TM7	292	I	7.31x30	Structure	Structure
TM7	293	D	7.32x31	Structure	Structure
TM7	294	R	7.33x32	Structure	Structure
TM7	295	A	7.34x33	Structure	Structure
TM7	296	L	7.35x34	Structure	Structure
TM7	297	D	7.36x35	Structure	Structure
TM7	298	A	7.37x36	Structure	Structure
TM7	299	T	7.38x37	Structure	Structure
TM7	300	E	7.39x38	Structure	Structure
TM7	301	I	7.40x39	Structure	Structure
TM7	302	L	7.41x40	Structure	Structure
TM7	303	G	7.42x41	Structure	Structure
TM7	304	I	7.43x42	Structure	Structure
TM7	305	L	7.44x43	Structure	Structure
TM7	306	H	7.45x45	Structure	Structure
TM7	307	S	7.46x46	Structure	Structure
TM7	308	C	7.47x47	Structure	Structure
TM7	309	L	7.48x48	Structure	Structure
TM7	310	N	7.49x49	Structure	Structure
TM7	311	P	7.50x50	Structure	Structure
TM7	312	L	7.51x51	Structure	Structure
TM7	313	I	7.52x52	Structure	Structure
TM7	314	Y	7.53x53	Structure	Structure
TM7	315	A	7.54x54	Structure	Structure
TM7	316	F	7.55x55	Structure	Structure
TM7	317	I	7.56x56	Structure	Structure
H8	318	G	8.47x47	Structure	Structure
H8	319	Q	8.48x48	Structure	Structure
H8	320	K	8.49x49	Structure	Structure
H8	321	F	8.50x50	Structure	Structure
H8	322	R	8.51x51	Structure	Structure
H8	323	H	8.52x52	Structure	Structure
H8	324	G	8.53x53	Structure	Structure
H8	325	L	8.54x54	Structure	Structure
H8	326	L	8.55x55	Structure	Structure
H8	327	K	8.56x56	Structure	Structure
H8	328	I	8.57x57	Structure	Structure
H8	329	L	8.58x58	Structure	Structure
H8	330	A	8.59x59	Structure	Structure
H8	331	I	8.60x60	Structure	Structure
H8	332	H	8.61x61	Structure	Structure
C-term	333	G	-	AF2	AF2
C-term	334	L	-	AF2	AF2
C-term	335	I	-	AF2	AF2
C-term	336	S	-	AF2	AF2
C-term	337	K	-	AF2	AF2
C-term	338	D	-	AF2	AF2
C-term	339	S	-	AF2	AF2
C-term	340	L	-	AF2	AF2
C-term	341	P	-	AF2	AF2
C-term	342	K	-	AF2	AF2

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Hydrophobic	TM2	S	81	2x37	G.H5	D	350	G.H5.22
Hydrophobic	ICL3	M	243	-	G.H5	D	341	G.H5.13
Hydrophobic	TM2	T	83	2x39	G.H5	C	351	G.H5.23
Hydrophobic	ICL3	M	243	-	G.H5	K	345	G.H5.17
Hydrophobic	ICL3	M	243	-	G.H5	L	348	G.H5.20
Hydrophobic	TM6	A	249	6x33	G.H5	L	348	G.H5.20
Hydrophobic	ICL3	M	243	-	G.H5	I	344	G.H5.16
Hydrophobic	ICL2	A	151	34x50	G.H5	I	344	G.H5.16
Hydrophobic	ICL2	A	151	34x50	G.H5	I	343	G.H5.15
Hydrophobic	H8	K	320	8x49	G.H5	D	350	G.H5.22
Hydrophobic	TM3	A	147	3x53	G.H5	N	347	G.H5.19
Hydrophobic	TM3	R	144	3x50	G.H5	C	351	G.H5.23
Hydrophobic	ICL2	T	152	34x51	G.H5	F	336	G.H5.08
Hydrophobic	ICL2	T	156	34x55	G.hns1	R	32	G.hns1.03
Hydrophobic	TM3	I	148	3x54	G.H5	L	353	G.H5.25
Hydrophobic	TM6	Q	245	6x29	G.H5	F	354	G.H5.26
Hydrophobic	TM6	V	252	6x36	G.H5	L	353	G.H5.25
Hydrophobic	TM3	A	147	3x53	G.H5	C	351	G.H5.23
Hydrophobic	TM5	T	237	5x64	G.H5	I	344	G.H5.16
Hydrophobic	ICL2	T	152	34x51	G.S3	L	194	G.S3.01
Hydrophobic	TM5	L	238	5x65	G.H5	L	348	G.H5.20
Hydrophobic	H8	G	318	8x47	G.H5	G	352	G.H5.24
Hydrophobic	TM3	I	148	3x54	G.H5	L	348	G.H5.20
Hydrophobic	ICL2	R	159	34x58	G.HN	E	28	G.HN.52
Hydrophobic	TM6	A	249	6x33	G.H5	L	353	G.H5.25
Hydrophobic	H8	Q	319	8x48	G.H5	K	349	G.H5.21
Hydrophobic	TM5	L	238	5x65	G.H5	I	344	G.H5.16
Hydrophobic	TM6	I	253	6x37	G.H5	L	353	G.H5.25
Hydrophobic	ICL3	H	242	-	G.H5	D	341	G.H5.13
Hydrophobic	TM3	I	148	3x54	G.H5	I	344	G.H5.16
Hydrophobic	TM3	R	144	3x50	G.H5	L	353	G.H5.25
Hydrophobic	TM7	I	317	7x56	G.H5	G	352	G.H5.24
Ionic	ICL3	H	242	-	G.H5	D	341	G.H5.13
Polar	TM2	S	81	2x37	G.H5	D	350	G.H5.22
Polar	ICL3	M	243	-	G.H5	D	341	G.H5.13
Polar	TM6	R	248	6x32	G.H5	F	354	G.H5.26
Polar	TM3	A	147	3x53	G.H5	N	347	G.H5.19
Polar	TM3	R	144	3x50	G.H5	C	351	G.H5.23
Polar	ICL2	T	156	34x55	G.hns1	R	32	G.hns1.03
Polar	H8	G	318	8x47	G.H5	G	352	G.H5.24
Polar	ICL2	L	155	34x54	G.hns1	R	32	G.hns1.03
Polar	ICL3	H	242	-	G.H5	D	341	G.H5.13
Polar	TM6	R	248	6x32	G.H5	L	353	G.H5.25
Polar	H8	Q	319	8x48	G.H5	F	354	G.H5.26
Van-der-waals	TM2	S	81	2x37	G.H5	D	350	G.H5.22
Van-der-waals	ICL3	M	243	-	G.H5	D	341	G.H5.13
Van-der-waals	ICL3	M	243	-	G.H5	K	345	G.H5.17
Van-der-waals	ICL2	R	159	34x58	G.hns1	R	32	G.hns1.03
Van-der-waals	TM6	R	248	6x32	G.H5	F	354	G.H5.26
Van-der-waals	ICL3	M	243	-	G.H5	I	344	G.H5.16
Van-der-waals	TM3	A	147	3x53	G.H5	N	347	G.H5.19
Van-der-waals	ICL2	T	156	34x55	G.hns1	R	32	G.hns1.03
Van-der-waals	TM6	Q	245	6x29	G.H5	F	354	G.H5.26
Van-der-waals	TM3	A	147	3x53	G.H5	C	351	G.H5.23
Van-der-waals	H8	G	318	8x47	G.H5	G	352	G.H5.24
Van-der-waals	TM3	I	148	3x54	G.H5	L	348	G.H5.20
Van-der-waals	ICL2	R	159	34x58	G.HN	E	28	G.HN.52
Van-der-waals	H8	Q	319	8x48	G.H5	K	349	G.H5.21
Van-der-waals	ICL3	H	242	-	G.H5	D	341	G.H5.13
Van-der-waals	TM3	R	144	3x50	G.H5	L	353	G.H5.25
Van-der-waals	TM7	I	317	7x56	G.H5	G	352	G.H5.24
Van-der-waals	TM6	R	248	6x32	G.H5	L	353	G.H5.25

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Main reference

Refined structure (6LFO) of Gi1 - CXCR2 Download Full

GPCR CLASS (FAMILY)

SPECIES

G PROTEIN FAMILY

DATE

3D VIEW

REFINED G PROTEIN RESIDUES

REFINED GPCR RESIDUES

GPCR - G protein interface interactions

Structures

Refined structure (6LFO) of G_i1 - CXCR2

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