Refined structure (8ZPT) of Gq - PrRP receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-11-27

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 204 from structure (56.8%), 155 from model (43.2%)
Residue sidechains - 108 from structure (30.1%), 251 from model (69.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 AF2 AF2
G.HN 12 S G.HN.30 AF2 AF2
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 AF2 AF2
G.hgh4 292 F G.hgh4.02 AF2 AF2
G.hgh4 293 P G.hgh4.03 AF2 AF2
G.hgh4 294 E G.hgh4.04 AF2 AF2
G.hgh4 295 Y G.hgh4.05 AF2 AF2
G.hgh4 296 D G.hgh4.06 AF2 AF2
G.hgh4 297 G G.hgh4.07 AF2 AF2
G.hgh4 298 P G.hgh4.08 AF2 AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 292 from structure (80.0%), 73 from model (20.0%)
Residue sidechains - 291 from structure (79.7%), 74 from model (20.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 R - AF2 AF2
N-term 8 G - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 R - AF2 AF2
N-term 11 V - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 D - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 F - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 L - AF2 AF2
N-term 19 P - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 V - AF2 AF2
N-term 23 T - AF2 AF2
N-term 24 T - AF2 AF2
N-term 25 P - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 N - AF2 AF2
N-term 28 Q - AF2 AF2
N-term 29 S - AF2 AF2
N-term 30 A - AF2 AF2
N-term 31 E - AF2 AF2
N-term 32 A - AF2 AF2
N-term 33 S - AF2 AF2
N-term 34 A - AF2 AF2
N-term 35 G - AF2 AF2
N-term 36 N - AF2 AF2
N-term 37 G - AF2 AF2
N-term 38 S - AF2 AF2
N-term 39 V - AF2 AF2
N-term 40 A - AF2 AF2
N-term 41 G - AF2 AF2
N-term 42 A - AF2 AF2
N-term 43 D - AF2 AF2
N-term 44 A - AF2 AF2
N-term 45 P - AF2 AF2
N-term 46 A - AF2 AF2
N-term 47 V - AF2 AF2
N-term 48 T - AF2 AF2
N-term 49 P - AF2 AF2
N-term 50 F - AF2 AF2
N-term 51 Q - AF2 AF2
N-term 52 S - AF2 AF2
N-term 53 L - AF2 AF2
N-term 54 Q - Structure Structure
N-term 55 L - Structure Structure
N-term 56 V - Structure Structure
N-term 57 H - Structure Structure
N-term 58 Q - Structure Structure
TM1 59 L 1.31x31 Structure Structure
TM1 60 K 1.32x32 Structure AF2
TM1 61 G 1.33x33 Structure Structure
TM1 62 L 1.34x34 Structure Structure
TM1 63 I 1.35x35 Structure Structure
TM1 64 V 1.36x36 Structure Structure
TM1 65 L 1.37x37 Structure Structure
TM1 66 L 1.38x38 Structure Structure
TM1 67 Y 1.39x39 Structure Structure
TM1 68 S 1.40x40 Structure Structure
TM1 69 V 1.41x41 Structure Structure
TM1 70 V 1.42x42 Structure Structure
TM1 71 V 1.43x43 Structure Structure
TM1 72 V 1.44x44 Structure Structure
TM1 73 V 1.45x45 Structure Structure
TM1 74 G 1.46x46 Structure Structure
TM1 75 L 1.47x47 Structure Structure
TM1 76 V 1.48x48 Structure Structure
TM1 77 G 1.49x49 Structure Structure
TM1 78 N 1.50x50 Structure Structure
TM1 79 C 1.51x51 Structure Structure
TM1 80 L 1.52x52 Structure Structure
TM1 81 L 1.53x53 Structure Structure
TM1 82 V 1.54x54 Structure Structure
TM1 83 L 1.55x55 Structure Structure
TM1 84 V 1.56x56 Structure Structure
TM1 85 I 1.57x57 Structure Structure
TM1 86 A 1.58x58 Structure Structure
TM1 87 R 1.59x59 Structure Structure
TM1 88 V 1.60x60 Structure Structure
ICL1 89 R 12.48x48 Structure Structure
ICL1 90 R 12.49x49 Structure Structure
ICL1 91 L 12.50x50 Structure Structure
ICL1 92 H 12.51x51 Structure Structure
TM2 93 N 2.37x37 Structure Structure
TM2 94 V 2.38x38 Structure Structure
TM2 95 T 2.39x39 Structure Structure
TM2 96 N 2.40x40 Structure Structure
TM2 97 F 2.41x41 Structure Structure
TM2 98 L 2.42x42 Structure Structure
TM2 99 I 2.43x43 Structure Structure
TM2 100 G 2.44x44 Structure Structure
TM2 101 N 2.45x45 Structure Structure
TM2 102 L 2.46x46 Structure Structure
TM2 103 A 2.47x47 Structure Structure
TM2 104 L 2.48x48 Structure Structure
TM2 105 S 2.49x49 Structure Structure
TM2 106 D 2.50x50 Structure Structure
TM2 107 V 2.51x51 Structure Structure
TM2 108 L 2.52x52 Structure Structure
TM2 109 M 2.53x53 Structure Structure
TM2 110 C 2.54x54 Structure Structure
TM2 111 T 2.55x55 Structure Structure
TM2 112 A 2.56x551 Structure Structure
TM2 113 C 2.57x56 Structure Structure
TM2 114 V 2.58x57 Structure Structure
TM2 115 P 2.59x58 Structure Structure
TM2 116 L 2.60x59 Structure Structure
TM2 117 T 2.61x60 Structure Structure
TM2 118 L 2.62x61 Structure Structure
TM2 119 A 2.63x62 Structure Structure
TM2 120 Y 2.64x63 Structure Structure
TM2 121 A 2.65x64 Structure Structure
TM2 122 F 2.66x65 Structure Structure
TM2 123 E 2.67x66 Structure Structure
TM2 124 P 2.68x67 Structure Structure
ECL1 125 R - Structure Structure
ECL1 126 G 23.49x49 Structure Structure
ECL1 127 W 23.50x50 Structure Structure
ECL1 128 V 23.51x51 Structure Structure
ECL1 129 F 23.52x52 Structure Structure
TM3 130 G 3.21x21 Structure Structure
TM3 131 G 3.22x22 Structure Structure
TM3 132 G 3.23x23 Structure Structure
TM3 133 L 3.24x24 Structure Structure
TM3 134 C 3.25x25 Structure Structure
TM3 135 H 3.26x26 Structure Structure
TM3 136 L 3.27x27 Structure Structure
TM3 137 V 3.28x28 Structure Structure
TM3 138 F 3.29x29 Structure Structure
TM3 139 F 3.30x30 Structure Structure
TM3 140 L 3.31x31 Structure Structure
TM3 141 Q 3.32x32 Structure Structure
TM3 142 P 3.33x33 Structure Structure
TM3 143 V 3.34x34 Structure Structure
TM3 144 T 3.35x35 Structure Structure
TM3 145 V 3.36x36 Structure Structure
TM3 146 Y 3.37x37 Structure Structure
TM3 147 V 3.38x38 Structure Structure
TM3 148 S 3.39x39 Structure Structure
TM3 149 V 3.40x40 Structure Structure
TM3 150 F 3.41x41 Structure Structure
TM3 151 T 3.42x42 Structure Structure
TM3 152 L 3.43x43 Structure Structure
TM3 153 T 3.44x44 Structure Structure
TM3 154 T 3.45x45 Structure Structure
TM3 155 I 3.46x46 Structure Structure
TM3 156 A 3.47x47 Structure Structure
TM3 157 V 3.48x48 Structure Structure
TM3 158 D 3.49x49 Structure Structure
TM3 159 R 3.50x50 Structure Structure
TM3 160 Y 3.51x51 Structure Structure
TM3 161 V 3.52x52 Structure Structure
TM3 162 V 3.53x53 Structure Structure
TM3 163 L 3.54x54 Structure Structure
TM3 164 V 3.55x55 Structure Structure
TM3 165 H 3.56x56 Structure Structure
ICL2 166 P 34.50x50 Structure Structure
ICL2 167 L 34.51x51 Structure Structure
ICL2 168 R 34.52x52 Structure Structure
ICL2 169 R 34.53x53 Structure Structure
ICL2 170 R - Structure Structure
ICL2 171 I - Structure Structure
TM4 172 S 4.38x38 Structure Structure
TM4 173 L 4.39x39 Structure Structure
TM4 174 R 4.40x40 Structure Structure
TM4 175 L 4.41x41 Structure Structure
TM4 176 S 4.42x42 Structure Structure
TM4 177 A 4.43x43 Structure Structure
TM4 178 Y 4.44x44 Structure Structure
TM4 179 A 4.45x45 Structure Structure
TM4 180 V 4.46x46 Structure Structure
TM4 181 L 4.47x47 Structure Structure
TM4 182 A 4.48x48 Structure Structure
TM4 183 I 4.49x49 Structure Structure
TM4 184 W 4.50x50 Structure Structure
TM4 185 A 4.51x51 Structure Structure
TM4 186 L 4.52x52 Structure Structure
TM4 187 S 4.53x53 Structure Structure
TM4 188 A 4.54x54 Structure Structure
TM4 189 V 4.55x55 Structure Structure
TM4 190 L 4.56x56 Structure Structure
TM4 191 A 4.57x57 Structure Structure
TM4 192 L 4.58x59 Structure Structure
TM4 193 P 4.59x60 Structure Structure
TM4 194 A 4.60x61 Structure Structure
TM4 195 A 4.61x62 Structure Structure
TM4 196 V 4.62x63 Structure Structure
TM4 197 H 4.63x64 Structure Structure
TM4 198 T 4.64x65 Structure Structure
ECL2 199 Y - Structure Structure
ECL2 200 H - Structure Structure
ECL2 201 V - Structure Structure
ECL2 202 E - Structure Structure
ECL2 203 L - Structure Structure
ECL2 204 K - Structure Structure
ECL2 205 P - Structure Structure
ECL2 206 H - Structure Structure
ECL2 207 D - Structure Structure
ECL2 208 V - Structure Structure
ECL2 209 R - Structure Structure
ECL2 210 L - Structure Structure
ECL2 211 C 45.50x50 Structure Structure
ECL2 212 E 45.51x51 Structure Structure
ECL2 213 E 45.52x52 Structure Structure
ECL2 214 F - Structure Structure
ECL2 215 W - Structure Structure
ECL2 216 G - Structure Structure
ECL2 217 S - Structure Structure
ECL2 218 Q - Structure Structure
TM5 219 E 5.32x33 Structure Structure
TM5 220 R 5.33x34 Structure Structure
TM5 221 Q 5.34x35 Structure Structure
TM5 222 R 5.35x36 Structure Structure
TM5 223 Q 5.36x37 Structure Structure
TM5 224 L 5.37x38 Structure Structure
TM5 225 Y 5.38x39 Structure Structure
TM5 226 A 5.39x40 Structure Structure
TM5 227 W 5.40x41 Structure Structure
TM5 228 G 5.41x42 Structure Structure
TM5 229 L 5.42x43 Structure Structure
TM5 230 L 5.43x44 Structure Structure
TM5 231 L 5.44x45 Structure Structure
TM5 232 V 5.45x46 Structure Structure
TM5 233 T 5.46x461 Structure Structure
TM5 234 Y 5.47x47 Structure Structure
TM5 235 L 5.48x48 Structure Structure
TM5 236 L 5.49x49 Structure Structure
TM5 237 P 5.50x50 Structure Structure
TM5 238 L 5.51x51 Structure Structure
TM5 239 L 5.52x52 Structure Structure
TM5 240 V 5.53x53 Structure Structure
TM5 241 I 5.54x54 Structure Structure
TM5 242 L 5.55x55 Structure Structure
TM5 243 L 5.56x56 Structure Structure
TM5 244 S 5.57x57 Structure Structure
TM5 245 Y 5.58x58 Structure Structure
TM5 246 V 5.59x59 Structure Structure
TM5 247 R 5.60x60 Structure Structure
TM5 248 V 5.61x61 Structure Structure
TM5 249 S 5.62x62 Structure Structure
TM5 250 V 5.63x63 Structure Structure
TM5 251 K 5.64x64 Structure Structure
TM5 252 L 5.65x65 Structure Structure
TM5 253 R 5.66x66 Structure Structure
TM5 254 N 5.67x67 Structure Structure
TM5 255 R 5.68x68 Structure Structure
TM5 256 V 5.69x69 Structure Structure
TM5 257 V 5.70x70 Structure Structure
TM5 258 P 5.71x71 Structure Structure
TM5 259 G 5.72x72 Structure Structure
TM5 260 C 5.73x73 AF2 AF2
ICL3 261 V - AF2 AF2
ICL3 262 T - AF2 AF2
ICL3 263 Q - AF2 AF2
ICL3 264 S - AF2 AF2
ICL3 265 Q - AF2 AF2
TM6 266 A 6.23x23 Structure Structure
TM6 267 D 6.24x24 Structure Structure
TM6 268 W 6.25x25 Structure Structure
TM6 269 D 6.26x26 Structure Structure
TM6 270 R 6.27x27 Structure Structure
TM6 271 A 6.28x28 Structure Structure
TM6 272 R 6.29x29 Structure Structure
TM6 273 R 6.30x30 Structure Structure
TM6 274 R 6.31x31 Structure Structure
TM6 275 R 6.32x32 Structure Structure
TM6 276 T 6.33x33 Structure Structure
TM6 277 F 6.34x34 Structure Structure
TM6 278 C 6.35x35 Structure Structure
TM6 279 L 6.36x36 Structure Structure
TM6 280 L 6.37x37 Structure Structure
TM6 281 V 6.38x38 Structure Structure
TM6 282 V 6.39x39 Structure Structure
TM6 283 I 6.40x40 Structure Structure
TM6 284 V 6.41x41 Structure Structure
TM6 285 V 6.42x42 Structure Structure
TM6 286 V 6.43x43 Structure Structure
TM6 287 F 6.44x44 Structure Structure
TM6 288 A 6.45x45 Structure Structure
TM6 289 V 6.46x46 Structure Structure
TM6 290 C 6.47x47 Structure Structure
TM6 291 W 6.48x48 Structure Structure
TM6 292 L 6.49x49 Structure Structure
TM6 293 P 6.50x50 Structure Structure
TM6 294 L 6.51x51 Structure Structure
TM6 295 H 6.52x52 Structure Structure
TM6 296 V 6.53x53 Structure Structure
TM6 297 F 6.54x54 Structure Structure
TM6 298 N 6.55x55 Structure Structure
TM6 299 L 6.56x56 Structure Structure
TM6 300 L 6.57x57 Structure Structure
TM6 301 R 6.58x58 Structure Structure
TM6 302 D 6.59x59 Structure Structure
TM6 303 L 6.60x60 Structure Structure
TM6 304 D 6.61x61 Structure Structure
ECL3 305 P - Structure Structure
ECL3 306 H - Structure Structure
ECL3 307 A - Structure Structure
ECL3 308 I - Structure Structure
TM7 309 D 7.27x26 Structure Structure
TM7 310 P 7.28x27 Structure Structure
TM7 311 Y 7.29x28 Structure Structure
TM7 312 A 7.30x29 Structure Structure
TM7 313 F 7.31x30 Structure Structure
TM7 314 G 7.32x31 Structure Structure
TM7 315 L 7.33x32 Structure Structure
TM7 316 V 7.34x33 Structure Structure
TM7 317 Q 7.35x34 Structure Structure
TM7 318 L 7.36x35 Structure Structure
TM7 319 L 7.37x36 Structure Structure
TM7 320 C 7.38x37 Structure Structure
TM7 321 H 7.39x38 Structure Structure
TM7 322 W 7.40x39 Structure Structure
TM7 323 L 7.41x40 Structure Structure
TM7 324 A 7.42x41 Structure Structure
TM7 325 M 7.43x42 Structure Structure
TM7 326 S 7.44x43 Structure Structure
TM7 327 S 7.45x45 Structure Structure
TM7 328 A 7.46x46 Structure Structure
TM7 329 C 7.47x47 Structure Structure
TM7 330 Y 7.48x48 Structure Structure
TM7 331 N 7.49x49 Structure Structure
TM7 332 P 7.50x50 Structure Structure
TM7 333 F 7.51x51 Structure Structure
TM7 334 I 7.52x52 Structure Structure
TM7 335 Y 7.53x53 Structure Structure
TM7 336 A 7.54x54 Structure Structure
TM7 337 W 7.55x55 Structure Structure
TM7 338 L 7.56x56 Structure Structure
H8 339 H 8.47x47 Structure Structure
H8 340 D 8.48x48 Structure Structure
H8 341 S 8.49x49 Structure Structure
H8 342 F 8.50x50 Structure Structure
H8 343 R 8.51x51 Structure Structure
H8 344 E 8.52x52 Structure Structure
H8 345 E 8.53x53 Structure Structure
H8 346 L 8.54x54 Structure Structure
H8 347 R 8.55x55 Structure Structure
H8 348 K 8.56x56 Structure Structure
H8 349 L 8.57x57 Structure Structure
H8 350 L 8.58x58 Structure Structure
H8 351 V 8.59x59 Structure Structure
H8 352 A 8.60x60 AF2 AF2
H8 353 W 8.61x61 AF2 AF2
H8 354 P 8.62x62 AF2 AF2
H8 355 R 8.63x63 AF2 AF2
C-term 356 K - AF2 AF2
C-term 357 I - AF2 AF2
C-term 358 A - AF2 AF2
C-term 359 P - AF2 AF2
C-term 360 H - AF2 AF2
C-term 361 G - AF2 AF2
C-term 362 Q - AF2 AF2
C-term 363 N - AF2 AF2
C-term 364 M - AF2 AF2
C-term 365 T - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 280 6x37 G.H5 L 358 G.H5.25
Van-der-waals C-term Q 362 - G.h2s4 E 221 G.h2s4.02
Hydrophobic TM3 L 163 3x54 G.H5 N 352 G.H5.19
Polar TM2 T 95 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 95 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 95 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 159 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 L 163 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM3 V 162 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 V 162 3x53 G.H5 Y 356 G.H5.23
Polar H8 H 339 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 H 339 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 H 339 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 166 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 166 34x50 G.H5 K 345 G.H5.12
Hydrophobic ICL2 P 166 34x50 G.H5 L 349 G.H5.16
Van-der-waals TM6 T 276 6x33 G.H5 V 359 G.H5.26
Hydrophobic H8 F 342 8x50 G.H5 N 357 G.H5.24
Hydrophobic TM5 C 260 5x73 G.H4 L 310 G.H4.12
Van-der-waals TM5 C 260 5x73 G.H4 L 310 G.H4.12
Hydrophobic ICL2 P 166 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 166 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 L 167 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM3 L 163 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 L 163 3x54 G.H5 L 353 G.H5.20
Polar TM3 V 162 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 V 162 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 L 163 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 L 163 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 167 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM5 C 260 5x73 G.H4 V 314 G.H4.16
Van-der-waals TM5 C 260 5x73 G.H4 V 314 G.H4.16
Polar C-term M 364 - G.H3 W 263 G.H3.17
Hydrophobic C-term M 364 - G.H3 W 263 G.H3.17
Van-der-waals C-term M 364 - G.H3 W 263 G.H3.17
Hydrophobic TM3 R 159 3x50 G.H5 Y 356 G.H5.23
Polar TM3 D 158 3x49 G.H5 Y 356 G.H5.23
Polar TM2 N 93 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 N 93 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 N 93 2x37 G.H5 E 355 G.H5.22
Polar H8 S 341 8x49 G.H5 N 357 G.H5.24
Hydrophobic H8 S 341 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 S 341 8x49 G.H5 N 357 G.H5.24
Hydrophobic TM5 C 260 5x73 G.H4 K 311 G.H4.13
Hydrophobic C-term Q 362 - G.H3 W 263 G.H3.17
Van-der-waals C-term Q 362 - G.H3 W 263 G.H3.17
Hydrophobic C-term T 365 - G.H2 H 218 G.H2.09
Van-der-waals C-term T 365 - G.H2 H 218 G.H2.09
Polar TM6 T 276 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 276 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 276 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 167 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 167 34x51 G.H5 I 348 G.H5.15
Polar ICL2 R 170 - G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 170 - G.H5 Y 356 G.H5.23
Hydrophobic TM5 P 258 5x71 G.S6 Y 325 G.S6.02
Van-der-waals TM5 P 258 5x71 G.S6 Y 325 G.S6.02
Hydrophobic TM5 L 252 5x65 G.H5 L 353 G.H5.20
Polar ICL2 P 166 34x50 G.H5 N 352 G.H5.19
Polar TM6 R 272 6x29 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM6 R 272 6x29 G.h4s6 S 320 G.h4s6.11
Van-der-waals TM6 R 272 6x29 G.h4s6 S 320 G.h4s6.11
Hydrophobic C-term N 363 - G.H3 W 263 G.H3.17