TSH receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XW5

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-022-05173-3

PUBLICATION DATE

Aug. 24, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

55 interactions (Click to see)

LIGANDS

N-[4-[[5-[(2S)-3-benzyl-5-hydroxy-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide - PAM pubchem ,

Glycoprotein hormones alpha chain - Agonist ,

Thyrotropin subunit beta - Agonist

PHYSIOLOGICAL LIGANDS

TSH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 D 530 - G.hns1 A 39 G.hns1.03
Polar TM3 R 519 3x50 G.H5 Y 381 G.H5.23
Aromatic TM3 R 519 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 519 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 A 522 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 A 522 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM5 T 607 5x64 G.H5 Q 374 G.H5.16
Van-der-waals TM5 T 607 5x64 G.H5 Q 374 G.H5.16
Hydrophobic TM6 M 626 6x37 G.H5 L 383 G.H5.25
Polar TM3 E 518 3x49 G.H5 Y 381 G.H5.23
Polar TM3 I 523 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 I 523 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 I 523 3x54 G.H5 Q 374 G.H5.16
Hydrophobic ICL2 A 526 - G.H5 I 373 G.H5.15
Hydrophobic TM6 R 625 6x36 G.H5 L 383 G.H5.25
Polar TM3 A 522 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM3 A 522 3x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 M 527 - G.H5 I 373 G.H5.15
Polar H8 K 683 8x48 G.H5 E 382 G.H5.24
Hydrophobic H8 K 683 8x48 G.H5 E 382 G.H5.24
Van-der-waals H8 K 683 8x48 G.H5 E 382 G.H5.24
Hydrophobic TM5 V 608 5x65 G.H5 Q 374 G.H5.16
Hydrophobic TM5 Y 601 5x58 G.H5 L 383 G.H5.25
Hydrophobic ICL2 M 527 - G.H5 C 369 G.H5.11
Van-der-waals ICL2 M 527 - G.H5 C 369 G.H5.11
Hydrophobic TM5 V 608 5x65 G.H5 L 378 G.H5.20
Hydrophobic TM3 I 523 3x54 G.H5 H 377 G.H5.19
Van-der-waals TM3 I 523 3x54 G.H5 H 377 G.H5.19
Hydrophobic H8 T 682 8x47 G.H5 E 382 G.H5.24
Van-der-waals H8 T 682 8x47 G.H5 E 382 G.H5.24
Hydrophobic ICL2 A 526 - G.H5 H 377 G.H5.19
Polar TM6 R 625 6x36 G.H5 E 382 G.H5.24
Hydrophobic TM6 R 625 6x36 G.H5 E 382 G.H5.24
Van-der-waals TM6 R 625 6x36 G.H5 E 382 G.H5.24
Hydrophobic TM3 I 523 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 M 527 - G.S3 V 217 G.S3.01
Hydrophobic TM6 K 621 6x32 G.H5 L 384 G.H5.26
Van-der-waals TM6 K 621 6x32 G.H5 L 384 G.H5.26
Hydrophobic TM6 I 622 6x33 G.H5 L 378 G.H5.20
Van-der-waals TM6 I 622 6x33 G.H5 L 378 G.H5.20
Hydrophobic TM6 K 618 6x29 G.H5 L 384 G.H5.26
Hydrophobic ICL2 A 526 - G.H5 Q 374 G.H5.16
Hydrophobic TM6 L 629 6x40 G.H5 L 383 G.H5.25
Hydrophobic TM5 I 604 5x61 G.H5 L 378 G.H5.20
Hydrophobic ICL2 L 529 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 529 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 529 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 M 527 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 M 527 - G.H5 F 366 G.H5.08
Hydrophobic ICL2 L 529 - G.S1 T 40 G.S1.01
Hydrophobic ICL2 M 527 - G.H5 R 370 G.H5.12
Van-der-waals ICL2 M 527 - G.H5 R 370 G.H5.12
Hydrophobic ICL2 R 528 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM3 I 523 3x54 G.H5 L 378 G.H5.20
Polar ICL2 M 527 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 M 527 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 M 527 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 528 - G.S3 V 217 G.S3.01
Hydrophobic TM6 I 622 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 I 622 6x33 G.H5 L 383 G.H5.25
Polar TM6 R 625 6x36 G.H5 L 384 G.H5.26
Hydrophobic TM6 R 625 6x36 G.H5 L 384 G.H5.26
Van-der-waals TM6 R 625 6x36 G.H5 L 384 G.H5.26