TAS2R14 - Ggust

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

July 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

compound 28.1 [PMID: 36847646] - Agonist pubchem gtoplig chembl_ligand ,

compound 28.1 [PMID: 36847646] - Allosteric agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM5 T 215 5x75 G.H5 K 228 G.H5.05
Hydrophobic TM5 T 215 5x75 G.H5 K 228 G.H5.05
Van-der-waals TM5 T 215 5x75 G.H5 K 228 G.H5.05
Polar H8 N 284 8x47 G.H5 C 246 G.H5.23
Hydrophobic TM3 I 111 3x54 G.H5 L 248 G.H5.25
Van-der-waals TM3 I 111 3x54 G.H5 L 248 G.H5.25
Polar TM3 K 110 3x53 G.H5 N 242 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 242 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 242 G.H5.19
Hydrophobic TM6 R 228 6x33 G.H5 F 249 G.H5.26
Van-der-waals TM6 R 228 6x33 G.H5 F 249 G.H5.26
Hydrophobic TM3 K 110 3x53 G.H5 C 246 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 C 246 G.H5.23
Hydrophobic TM5 M 205 5x65 G.H5 L 243 G.H5.20
Van-der-waals TM5 M 205 5x65 G.H5 L 243 G.H5.20
Hydrophobic TM5 M 205 5x65 G.H5 I 239 G.H5.16
Van-der-waals TM5 M 205 5x65 G.H5 I 239 G.H5.16
Hydrophobic TM5 H 208 5x68 G.H5 T 235 G.H5.12
Van-der-waals TM5 H 208 5x68 G.H5 T 235 G.H5.12
Hydrophobic TM5 H 208 5x68 G.H5 I 239 G.H5.16
Van-der-waals TM5 H 208 5x68 G.H5 I 239 G.H5.16
Hydrophobic ICL3 H 227 - G.H5 L 243 G.H5.20
Van-der-waals ICL3 H 227 - G.H5 L 243 G.H5.20
Van-der-waals ICL3 H 227 - G.H5 K 240 G.H5.17
Hydrophobic TM5 M 212 5x72 G.H5 D 232 G.H5.09
Van-der-waals TM5 M 212 5x72 G.H5 D 232 G.H5.09
Hydrophobic ICL3 I 218 - G.H4 D 178 G.H4.05
Van-der-waals ICL3 I 218 - G.H4 D 178 G.H4.05
Hydrophobic TM7 G 283 7x56 G.H5 L 248 G.H5.25
Van-der-waals TM7 G 283 7x56 G.H5 L 248 G.H5.25
Ionic TM5 R 209 5x69 G.H5 D 236 G.H5.13
Polar TM5 R 209 5x69 G.H5 D 236 G.H5.13
Van-der-waals TM5 R 209 5x69 G.H5 D 236 G.H5.13
Hydrophobic TM3 F 106 3x49 G.H5 C 246 G.H5.23
Van-der-waals TM3 F 106 3x49 G.H5 C 246 G.H5.23
Hydrophobic TM3 I 111 3x54 G.H5 C 246 G.H5.23
Van-der-waals TM3 I 111 3x54 G.H5 C 246 G.H5.23
Polar H8 N 284 8x47 G.H5 G 247 G.H5.24
Hydrophobic TM3 Y 107 3x50 G.H5 L 248 G.H5.25
Van-der-waals TM3 Y 107 3x50 G.H5 L 248 G.H5.25
Hydrophobic ICL3 S 219 - G.h4s6 L 201 G.h4s6.04
Ionic TM5 K 211 5x71 G.H5 D 232 G.H5.09
Hydrophobic TM5 K 211 5x71 G.H5 D 232 G.H5.09
Van-der-waals TM5 K 211 5x71 G.H5 D 232 G.H5.09
Ionic TM3 K 110 3x53 G.H5 D 245 G.H5.22
Polar TM3 K 110 3x53 G.H5 D 245 G.H5.22
Van-der-waals TM3 K 110 3x53 G.H5 D 245 G.H5.22
Hydrophobic TM5 M 212 5x72 G.H5 D 236 G.H5.13
Van-der-waals TM5 M 212 5x72 G.H5 D 236 G.H5.13
Hydrophobic H8 K 285 8x48 G.H5 F 249 G.H5.26
Van-der-waals H8 K 285 8x48 G.H5 F 249 G.H5.26
Hydrophobic TM5 V 216 5x76 G.S6 H 217 G.S6.04
Van-der-waals TM5 V 216 5x76 G.S6 H 217 G.S6.04
Hydrophobic TM6 G 229 6x34 G.H5 L 243 G.H5.20
Van-der-waals TM6 G 229 6x34 G.H5 L 243 G.H5.20
Hydrophobic TM3 Y 107 3x50 G.H5 C 246 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 C 246 G.H5.23
Hydrophobic TM2 V 44 2x39 G.H5 C 246 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 C 246 G.H5.23
Hydrophobic TM5 V 216 5x76 G.H5 D 232 G.H5.09
Polar H8 K 285 8x48 G.H5 G 247 G.H5.24
Hydrophobic H8 K 285 8x48 G.H5 G 247 G.H5.24
Van-der-waals H8 K 285 8x48 G.H5 G 247 G.H5.24
Hydrophobic ICL2 W 124 - G.hns1 R 34 G.hns1.02
Van-der-waals ICL2 W 124 - G.hns1 R 34 G.hns1.02
Polar ICL3 S 219 - G.H4 R 197 G.H4.17
Hydrophobic TM3 I 111 3x54 G.H5 N 242 G.H5.19
Van-der-waals TM3 I 111 3x54 G.H5 N 242 G.H5.19
Polar TM5 K 211 5x71 G.H5 T 235 G.H5.12
Van-der-waals TM5 K 211 5x71 G.H5 T 235 G.H5.12
Ionic TM5 H 208 5x68 G.H5 D 236 G.H5.13
Polar TM5 H 208 5x68 G.H5 D 236 G.H5.13
Hydrophobic TM5 H 208 5x68 G.H5 D 236 G.H5.13
Van-der-waals TM5 H 208 5x68 G.H5 D 236 G.H5.13
Hydrophobic TM3 I 111 3x54 G.H5 L 243 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 243 G.H5.20
Polar TM5 T 215 5x75 G.H5 D 232 G.H5.09
Van-der-waals TM5 T 215 5x75 G.H5 D 232 G.H5.09
Hydrophobic ICL2 N 113 - G.H5 I 239 G.H5.16
Van-der-waals ICL2 N 113 - G.H5 I 239 G.H5.16