H2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

March 6, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 A 215 5x65 G.H5 L 379 G.H5.25
Hydrophobic TM3 V 126 3x54 G.H5 H 373 G.H5.19
Hydrophobic ICL2 L 130 - G.H5 R 366 G.H5.12
Hydrophobic ICL2 L 130 - G.H5 I 369 G.H5.15
Van-der-waals TM5 V 214 5x64 G.H5 Q 370 G.H5.16
Hydrophobic TM6 L 242 6x37 G.H5 L 379 G.H5.25
Hydrophobic TM5 I 222 5x72 G.H5 R 371 G.H5.17
Hydrophobic TM5 I 211 5x61 G.H5 L 379 G.H5.25
Hydrophobic TM3 V 126 3x54 G.H5 L 374 G.H5.20
Ionic TM5 R 221 5x71 G.H5 D 367 G.H5.13
Polar TM5 R 221 5x71 G.H5 D 367 G.H5.13
Hydrophobic TM5 I 222 5x72 G.h4s6 Y 344 G.h4s6.20
Van-der-waals TM5 I 222 5x72 G.h4s6 Y 344 G.h4s6.20
Hydrophobic C-term L 297 - G.H5 E 378 G.H5.24
Van-der-waals C-term L 297 - G.H5 E 378 G.H5.24
Hydrophobic TM5 A 215 5x65 G.H5 L 374 G.H5.20
Hydrophobic ICL3 I 225 - G.h4s6 Y 344 G.h4s6.20
Van-der-waals C-term N 298 - G.H5 Q 376 G.H5.22
Hydrophobic ICL2 P 129 - G.H5 Q 370 G.H5.16
Hydrophobic ICL2 L 130 - G.S3 V 203 G.S3.01
Ionic C-term R 302 - G.H5 E 378 G.H5.24
Polar C-term R 302 - G.H5 E 378 G.H5.24
Van-der-waals C-term R 302 - G.H5 E 378 G.H5.24
Aromatic TM3 R 122 3x50 G.H5 Y 377 G.H5.23
Hydrophobic TM3 R 122 3x50 G.H5 Y 377 G.H5.23
Ionic C-term R 299 - G.H5 E 378 G.H5.24
Polar C-term R 299 - G.H5 E 378 G.H5.24
Polar C-term R 299 - G.H5 Q 376 G.H5.22
Hydrophobic C-term R 299 - G.H5 Q 376 G.H5.22
Van-der-waals C-term R 299 - G.H5 Q 376 G.H5.22
Hydrophobic ICL2 R 131 - G.s2s3 K 202 G.s2s3.02
Van-der-waals C-term D 300 - G.H5 Q 376 G.H5.22
Hydrophobic ICL2 V 134 - G.hns1 A 39 G.hns1.03
Polar TM5 Q 218 5x68 G.H5 R 371 G.H5.17
Hydrophobic TM5 Q 218 5x68 G.H5 R 371 G.H5.17
Van-der-waals TM5 Q 218 5x68 G.H5 R 371 G.H5.17
Ionic TM6 K 237 6x32 G.H5 E 378 G.H5.24
Polar TM6 K 237 6x32 G.H5 E 378 G.H5.24
Hydrophobic TM6 A 238 6x33 G.H5 L 379 G.H5.25
Hydrophobic ICL2 P 129 - G.H5 I 369 G.H5.15
Van-der-waals ICL2 P 129 - G.H5 I 369 G.H5.15
Polar TM3 A 125 3x53 G.H5 H 373 G.H5.19
Hydrophobic TM3 A 125 3x53 G.H5 H 373 G.H5.19
Van-der-waals TM3 A 125 3x53 G.H5 H 373 G.H5.19
Van-der-waals TM5 Q 218 5x68 G.H5 L 374 G.H5.20
Hydrophobic ICL2 P 129 - G.H5 R 366 G.H5.12
Polar C-term R 299 - G.H5 R 375 G.H5.21
Hydrophobic ICL2 L 130 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 130 - G.H5 F 362 G.H5.08
Van-der-waals ICL2 L 130 - G.H5 F 362 G.H5.08
Polar TM6 T 241 6x36 G.H5 E 378 G.H5.24