motilin receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

April 12, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

motilin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM6 H 293 6x30 G.H5 Q 352 G.H5.17
Hydrophobic TM6 H 293 6x30 G.H5 Q 352 G.H5.17
Van-der-waals TM6 H 293 6x30 G.H5 Q 352 G.H5.17
Hydrophobic TM3 R 136 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 136 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM2 T 73 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM3 I 140 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM3 I 140 3x54 G.H5 L 360 G.H5.25
Hydrophobic TM2 L 77 2x43 G.H5 N 359 G.H5.24
Hydrophobic TM6 T 296 6x33 G.H5 V 361 G.H5.26
Polar TM3 R 136 3x50 G.H5 Y 358 G.H5.23
Polar TM2 T 71 2x37 G.H5 E 357 G.H5.22
Hydrophobic TM2 T 71 2x37 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 71 2x37 G.H5 E 357 G.H5.22
Hydrophobic TM3 I 140 3x54 G.H5 L 351 G.H5.16
Hydrophobic ICL2 V 148 - G.hns1 R 32 G.hns1.03
Polar H8 S 359 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 S 359 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 S 359 8x47 G.H5 N 359 G.H5.24
Polar ICL2 R 147 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 147 - G.hns1 R 32 G.hns1.03
Polar TM3 R 136 3x50 G.H5 N 359 G.H5.24
Van-der-waals TM3 R 136 3x50 G.H5 N 359 G.H5.24
Hydrophobic ICL2 L 144 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 144 - G.H5 I 350 G.H5.15
Polar TM3 A 139 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 L 144 - G.H5 K 347 G.H5.12
Van-der-waals ICL4 I 358 - G.H5 V 361 G.H5.26
Polar ICL2 R 145 - G.s2s3 K 193 G.s2s3.02
Hydrophobic ICL2 R 145 - G.s2s3 K 193 G.s2s3.02
Van-der-waals ICL2 R 145 - G.s2s3 K 193 G.s2s3.02
Hydrophobic H8 K 360 8x48 G.H5 V 361 G.H5.26
Hydrophobic TM3 I 140 3x54 G.H5 N 354 G.H5.19
Van-der-waals TM3 I 140 3x54 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 Y 358 G.H5.23
Hydrophobic TM6 T 296 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 T 296 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM2 T 73 2x39 G.H5 N 359 G.H5.24
Van-der-waals TM2 T 73 2x39 G.H5 N 359 G.H5.24
Hydrophobic TM6 H 293 6x30 G.H5 L 355 G.H5.20
Van-der-waals TM6 H 293 6x30 G.H5 L 355 G.H5.20
Hydrophobic TM6 L 300 6x37 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 144 - G.H5 F 343 G.H5.08
Hydrophobic TM3 I 140 3x54 G.H5 L 355 G.H5.20