β2-adrenoceptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

3SN6

RESOLUTION

3.2 Å

REFERENCE

10.1038/NATURE10361

PUBLICATION DATE

July 20, 2011

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

48 interactions (Click to see)

LIGANDS

CHEMBL1615159 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

(-)-adrenaline, Zn2+, L-NOREPINEPHRINE, noradrenaline, (-)-noradrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 139 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 139 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 139 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 139 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 I 135 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 135 3x54 G.H5 L 393 G.H5.25
Aromatic ICL2 F 139 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 139 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 139 34x51 G.H5 F 376 G.H5.08
Aromatic ICL2 F 139 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 139 34x51 G.S1 H 41 G.S1.02
Polar ICL3 R 239 - G.H4 D 343 G.H4.13
Polar ICL3 R 239 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 R 239 - G.h4s6 T 350 G.h4s6.03
Polar TM3 T 136 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 T 136 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM5 V 222 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 222 5x61 G.H5 L 393 G.H5.25
Polar ICL2 Q 142 34x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 230 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 230 5x69 G.H5 L 394 G.H5.26
Ionic TM5 K 232 5x71 G.H5 D 381 G.H5.13
Polar TM5 K 232 5x71 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 232 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 232 5x71 G.H5 D 381 G.H5.13
Aromatic ICL2 Y 141 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 141 34x53 G.H5 H 387 G.H5.19
Polar TM5 Q 229 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 135 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 135 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 275 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 275 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 233 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 233 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 T 274 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 274 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 138 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 138 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 Q 142 34x54 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 138 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL3 R 239 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 S 143 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 S 143 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 P 138 34x50 G.H5 H 387 G.H5.19
Aromatic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Polar TM3 A 134 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 A 271 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 271 6x33 G.H5 L 393 G.H5.25
Polar TM3 I 135 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 Q 384 G.H5.16
Polar TM6 T 274 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 274 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 274 6x36 G.H5 E 392 G.H5.24
Polar TM5 R 228 5x67 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 R 239 - G.H4 L 346 G.H4.16
Ionic TM5 R 228 5x67 G.H5 D 381 G.H5.13
Hydrophobic ICL2 F 139 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 I 233 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 233 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 229 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 139 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM3 I 135 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 233 5x72 G.H5 L 394 G.H5.26
Polar TM5 Q 229 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 229 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 229 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 A 226 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 226 5x65 G.H5 L 388 G.H5.20
Ionic TM5 E 225 5x64 G.H5 R 380 G.H5.12
Polar TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 138 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 383 G.H5.15
Polar TM5 E 225 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 E 225 5x64 G.H5 Q 384 G.H5.16