Refined structure (8IBV) of Gq - motilin receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 215 from structure (59.9%), 144 from model (40.1%)
Residue sidechains - 114 from structure (31.8%), 245 from model (68.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure AF2
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure AF2
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure AF2
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure AF2
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure Structure
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure AF2
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 279 from structure (72.7%), 105 from model (27.3%)
Residue sidechains - 279 from structure (72.7%), 105 from model (27.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 G - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 P - AF2 AF2
N-term 5 W - AF2 AF2
N-term 6 N - AF2 AF2
N-term 7 G - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 D - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 G - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 R - AF2 AF2
N-term 16 E - AF2 AF2
N-term 17 P - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 W - AF2 AF2
N-term 20 P - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 P - AF2 AF2
N-term 24 P - AF2 AF2
N-term 25 C - AF2 AF2
N-term 26 D - AF2 AF2
N-term 27 E - AF2 AF2
N-term 28 R - AF2 AF2
N-term 29 R - AF2 AF2
N-term 30 C - Structure Structure
N-term 31 S - Structure Structure
N-term 32 P - Structure Structure
N-term 33 F - Structure Structure
TM1 34 P 1.28x28 Structure Structure
TM1 35 L 1.29x29 Structure Structure
TM1 36 G 1.30x30 Structure Structure
TM1 37 A 1.31x31 Structure Structure
TM1 38 L 1.32x32 Structure Structure
TM1 39 V 1.33x33 Structure Structure
TM1 40 P 1.34x34 Structure Structure
TM1 41 V 1.35x35 Structure Structure
TM1 42 T 1.36x36 Structure Structure
TM1 43 A 1.37x37 Structure Structure
TM1 44 V 1.38x38 Structure Structure
TM1 45 C 1.39x39 Structure Structure
TM1 46 L 1.40x40 Structure Structure
TM1 47 C 1.41x41 Structure Structure
TM1 48 L 1.42x42 Structure Structure
TM1 49 F 1.43x43 Structure Structure
TM1 50 V 1.44x44 Structure Structure
TM1 51 V 1.45x45 Structure Structure
TM1 52 G 1.46x46 Structure Structure
TM1 53 V 1.47x47 Structure Structure
TM1 54 S 1.48x48 Structure Structure
TM1 55 G 1.49x49 Structure Structure
TM1 56 N 1.50x50 Structure Structure
TM1 57 V 1.51x51 Structure Structure
TM1 58 V 1.52x52 Structure Structure
TM1 59 T 1.53x53 Structure Structure
TM1 60 V 1.54x54 Structure Structure
TM1 61 M 1.55x55 Structure Structure
TM1 62 L 1.56x56 Structure Structure
TM1 63 I 1.57x57 Structure Structure
TM1 64 G 1.58x58 Structure Structure
TM1 65 R 1.59x59 Structure Structure
TM1 66 Y 1.60x60 Structure Structure
ICL1 67 R 12.48x48 Structure Structure
ICL1 68 D 12.49x49 Structure Structure
ICL1 69 M 12.50x50 Structure Structure
ICL1 70 R 12.51x51 Structure Structure
TM2 71 T 2.37x37 Structure Structure
TM2 72 T 2.38x38 Structure Structure
TM2 73 T 2.39x39 Structure Structure
TM2 74 N 2.40x40 Structure Structure
TM2 75 L 2.41x41 Structure Structure
TM2 76 Y 2.42x42 Structure Structure
TM2 77 L 2.43x43 Structure Structure
TM2 78 G 2.44x44 Structure Structure
TM2 79 S 2.45x45 Structure Structure
TM2 80 M 2.46x46 Structure Structure
TM2 81 A 2.47x47 Structure Structure
TM2 82 V 2.48x48 Structure Structure
TM2 83 S 2.49x49 Structure Structure
TM2 84 D 2.50x50 Structure Structure
TM2 85 L 2.51x51 Structure Structure
TM2 86 L 2.52x52 Structure Structure
TM2 87 I 2.53x53 Structure Structure
TM2 88 L 2.54x54 Structure Structure
TM2 89 L 2.55x55 Structure Structure
TM2 90 G 2.56x56 Structure Structure
TM2 91 L 2.57x57 Structure Structure
TM2 92 P 2.58x58 Structure Structure
TM2 93 F 2.59x59 Structure Structure
TM2 94 D 2.60x60 Structure Structure
TM2 95 L 2.61x61 Structure Structure
TM2 96 Y 2.62x62 Structure Structure
TM2 97 R 2.63x63 Structure Structure
TM2 98 L 2.64x64 Structure Structure
TM2 99 W 2.65x65 Structure Structure
TM2 100 R 2.66x66 Structure Structure
TM2 101 S 2.67x67 Structure Structure
ECL1 102 R - Structure Structure
ECL1 103 P 23.49x49 Structure Structure
ECL1 104 W 23.50x50 Structure Structure
ECL1 105 V 23.51x51 Structure Structure
ECL1 106 F 23.52x52 Structure Structure
TM3 107 G 3.21x21 Structure Structure
TM3 108 P 3.22x22 Structure Structure
TM3 109 L 3.23x23 Structure Structure
TM3 110 L 3.24x24 Structure Structure
TM3 111 C 3.25x25 Structure Structure
TM3 112 R 3.26x26 Structure Structure
TM3 113 L 3.27x27 Structure Structure
TM3 114 S 3.28x28 Structure Structure
TM3 115 L 3.29x29 Structure Structure
TM3 116 Y 3.30x30 Structure Structure
TM3 117 V 3.31x31 Structure Structure
TM3 118 G 3.32x32 Structure Structure
TM3 119 E 3.33x33 Structure Structure
TM3 120 G 3.34x34 Structure Structure
TM3 121 C 3.35x35 Structure Structure
TM3 122 T 3.36x36 Structure Structure
TM3 123 Y 3.37x37 Structure Structure
TM3 124 A 3.38x38 Structure Structure
TM3 125 T 3.39x39 Structure Structure
TM3 126 L 3.40x40 Structure Structure
TM3 127 L 3.41x41 Structure Structure
TM3 128 H 3.42x42 Structure Structure
TM3 129 M 3.43x43 Structure Structure
TM3 130 T 3.44x44 Structure Structure
TM3 131 A 3.45x45 Structure Structure
TM3 132 L 3.46x46 Structure Structure
TM3 133 S 3.47x47 Structure Structure
TM3 134 V 3.48x48 Structure Structure
TM3 135 E 3.49x49 Structure Structure
TM3 136 R 3.50x50 Structure Structure
TM3 137 Y 3.51x51 Structure Structure
TM3 138 L 3.52x52 Structure Structure
TM3 139 A 3.53x53 Structure Structure
TM3 140 I 3.54x54 Structure Structure
TM3 141 C 3.55x55 Structure Structure
TM3 142 R 3.56x56 Structure Structure
ICL2 143 P 34.50x50 Structure Structure
ICL2 144 L 34.51x51 AF2 AF2
ICL2 145 R 34.52x52 AF2 AF2
ICL2 146 A 34.53x53 AF2 AF2
ICL2 147 R 34.54x54 AF2 AF2
ICL2 148 V 34.55x55 AF2 AF2
ICL2 149 L 34.56x56 AF2 AF2
ICL2 150 V 34.57x57 Structure Structure
TM4 151 T 4.38x38 Structure Structure
TM4 152 R 4.39x39 Structure Structure
TM4 153 R 4.40x40 Structure Structure
TM4 154 R 4.41x41 Structure Structure
TM4 155 V 4.42x42 Structure Structure
TM4 156 R 4.43x43 Structure Structure
TM4 157 A 4.44x44 Structure Structure
TM4 158 L 4.45x45 Structure Structure
TM4 159 I 4.46x46 Structure Structure
TM4 160 A 4.47x47 Structure Structure
TM4 161 V 4.48x48 Structure Structure
TM4 162 L 4.49x49 Structure Structure
TM4 163 W 4.50x50 Structure Structure
TM4 164 A 4.51x51 Structure Structure
TM4 165 V 4.52x52 Structure Structure
TM4 166 A 4.53x53 Structure Structure
TM4 167 L 4.54x54 Structure Structure
TM4 168 L 4.55x55 Structure Structure
TM4 169 S 4.56x56 Structure Structure
TM4 170 A 4.57x57 Structure Structure
TM4 171 G 4.58x59 Structure Structure
TM4 172 P 4.59x60 Structure Structure
TM4 173 F 4.60x61 Structure Structure
TM4 174 L 4.61x62 Structure Structure
TM4 175 F 4.62x63 Structure Structure
TM4 176 L 4.63x64 Structure Structure
TM4 177 V 4.64x65 Structure Structure
ECL2 178 G - Structure Structure
ECL2 179 V - Structure Structure
ECL2 180 E - Structure Structure
ECL2 181 Q - Structure Structure
ECL2 182 D - Structure Structure
ECL2 183 P - AF2 AF2
ECL2 184 G - AF2 AF2
ECL2 185 I - AF2 AF2
ECL2 186 S - AF2 AF2
ECL2 187 V - AF2 AF2
ECL2 188 V - AF2 AF2
ECL2 189 P - AF2 AF2
ECL2 190 G - AF2 AF2
ECL2 191 L - AF2 AF2
ECL2 192 N - AF2 AF2
ECL2 193 G - AF2 AF2
ECL2 194 T - AF2 AF2
ECL2 195 A - AF2 AF2
ECL2 196 R - AF2 AF2
ECL2 197 I - AF2 AF2
ECL2 198 A - AF2 AF2
ECL2 199 S - AF2 AF2
ECL2 200 S - AF2 AF2
ECL2 201 P - AF2 AF2
ECL2 202 L - AF2 AF2
ECL2 203 A - AF2 AF2
ECL2 204 S - AF2 AF2
ECL2 205 S - AF2 AF2
ECL2 206 P - AF2 AF2
ECL2 207 P - AF2 AF2
ECL2 208 L - AF2 AF2
ECL2 209 W - AF2 AF2
ECL2 210 L - AF2 AF2
ECL2 211 S - AF2 AF2
ECL2 212 R - AF2 AF2
ECL2 213 A - AF2 AF2
ECL2 214 P - AF2 AF2
ECL2 215 P - AF2 AF2
ECL2 216 P - AF2 AF2
ECL2 217 S - AF2 AF2
ECL2 218 P - AF2 AF2
ECL2 219 P - AF2 AF2
ECL2 220 S - AF2 AF2
ECL2 221 G - AF2 AF2
ECL2 222 P - AF2 AF2
ECL2 223 E - AF2 AF2
ECL2 224 T - AF2 AF2
ECL2 225 A - Structure Structure
ECL2 226 E - Structure Structure
ECL2 227 A - Structure Structure
ECL2 228 A - Structure Structure
ECL2 229 A - Structure Structure
ECL2 230 L - Structure Structure
ECL2 231 F - Structure Structure
ECL2 232 S - Structure Structure
ECL2 233 R - Structure Structure
ECL2 234 E - Structure Structure
ECL2 235 C 45.50x50 Structure Structure
ECL2 236 R 45.51x51 Structure Structure
ECL2 237 P 45.52x52 Structure Structure
ECL2 238 S - Structure Structure
ECL2 239 P - Structure Structure
ECL2 240 A - Structure Structure
TM5 241 Q 5.32x33 Structure Structure
TM5 242 L 5.33x34 Structure Structure
TM5 243 G 5.34x35 Structure Structure
TM5 244 A 5.35x36 Structure Structure
TM5 245 L 5.36x37 Structure Structure
TM5 246 R 5.37x38 Structure Structure
TM5 247 V 5.38x39 Structure Structure
TM5 248 M 5.39x40 Structure Structure
TM5 249 L 5.40x41 Structure Structure
TM5 250 W 5.41x42 Structure Structure
TM5 251 V 5.42x43 Structure Structure
TM5 252 T 5.43x44 Structure Structure
TM5 253 T 5.44x45 Structure Structure
TM5 254 A 5.45x46 Structure Structure
TM5 255 Y 5.46x461 Structure Structure
TM5 256 F 5.47x47 Structure Structure
TM5 257 F 5.48x48 Structure Structure
TM5 258 L 5.49x49 Structure Structure
TM5 259 P 5.50x50 Structure Structure
TM5 260 F 5.51x51 Structure Structure
TM5 261 L 5.52x52 Structure Structure
TM5 262 C 5.53x53 Structure Structure
TM5 263 L 5.54x54 Structure Structure
TM5 264 S 5.55x55 Structure Structure
TM5 265 I 5.56x56 Structure Structure
TM5 266 L 5.57x57 Structure Structure
TM5 267 Y 5.58x58 Structure Structure
TM5 268 G 5.59x59 Structure Structure
TM5 269 L 5.60x60 Structure Structure
TM5 270 I 5.61x61 Structure Structure
TM5 271 G 5.62x62 Structure Structure
TM5 272 R 5.63x63 Structure Structure
TM5 273 E 5.64x64 Structure Structure
TM5 274 L 5.65x65 Structure Structure
TM5 275 W 5.66x66 Structure Structure
TM5 276 S 5.67x67 Structure Structure
TM5 277 S 5.68x68 AF2 AF2
TM5 278 R 5.69x69 AF2 AF2
TM5 279 R 5.70x70 AF2 AF2
TM5 280 P 5.71x71 AF2 AF2
TM5 281 L 5.72x72 AF2 AF2
ICL3 282 R - AF2 AF2
ICL3 283 G - AF2 AF2
ICL3 284 P - AF2 AF2
ICL3 285 A - AF2 AF2
ICL3 286 A - AF2 AF2
TM6 287 S 6.24x24 AF2 AF2
TM6 288 G 6.25x25 AF2 AF2
TM6 289 R 6.26x26 AF2 AF2
TM6 290 E 6.27x27 AF2 AF2
TM6 291 R 6.28x28 AF2 AF2
TM6 292 G 6.29x29 Structure Structure
TM6 293 H 6.30x30 Structure Structure
TM6 294 R 6.31x31 Structure Structure
TM6 295 Q 6.32x32 Structure Structure
TM6 296 T 6.33x33 Structure Structure
TM6 297 V 6.34x34 Structure Structure
TM6 298 R 6.35x35 Structure Structure
TM6 299 V 6.36x36 Structure Structure
TM6 300 L 6.37x37 Structure Structure
TM6 301 L 6.38x38 Structure Structure
TM6 302 V 6.39x39 Structure Structure
TM6 303 V 6.40x40 Structure Structure
TM6 304 V 6.41x41 Structure Structure
TM6 305 L 6.42x42 Structure Structure
TM6 306 A 6.43x43 Structure Structure
TM6 307 F 6.44x44 Structure Structure
TM6 308 I 6.45x45 Structure Structure
TM6 309 I 6.46x46 Structure Structure
TM6 310 C 6.47x47 Structure Structure
TM6 311 W 6.48x48 Structure Structure
TM6 312 L 6.49x49 Structure Structure
TM6 313 P 6.50x50 Structure Structure
TM6 314 F 6.51x51 Structure Structure
TM6 315 H 6.52x52 Structure Structure
TM6 316 V 6.53x53 Structure Structure
TM6 317 G 6.54x54 Structure Structure
TM6 318 R 6.55x55 Structure Structure
TM6 319 I 6.56x56 Structure Structure
TM6 320 I 6.57x57 Structure Structure
TM6 321 Y 6.58x58 Structure Structure
TM6 322 I 6.59x59 Structure Structure
TM6 323 N 6.60x60 Structure Structure
TM6 324 T 6.61x61 Structure Structure
ECL3 325 E - Structure Structure
ECL3 326 D - Structure Structure
TM7 327 S 7.25x24 Structure Structure
TM7 328 R 7.26x25 Structure Structure
TM7 329 M 7.27x26 Structure Structure
TM7 330 M 7.28x27 Structure Structure
TM7 331 Y 7.29x28 Structure Structure
TM7 332 F 7.30x29 Structure Structure
TM7 333 S 7.31x30 Structure Structure
TM7 334 Q 7.32x31 Structure Structure
TM7 335 Y 7.33x32 Structure Structure
TM7 336 F 7.34x33 Structure Structure
TM7 337 N 7.35x34 Structure Structure
TM7 338 I 7.36x35 Structure Structure
TM7 339 V 7.37x36 Structure Structure
TM7 340 A 7.38x37 Structure Structure
TM7 341 L 7.39x38 Structure Structure
TM7 342 Q 7.40x39 Structure Structure
TM7 343 L 7.41x40 Structure Structure
TM7 344 F 7.42x41 Structure Structure
TM7 345 Y 7.43x42 Structure Structure
TM7 346 L 7.44x43 Structure Structure
TM7 347 S 7.45x45 Structure Structure
TM7 348 A 7.46x46 Structure Structure
TM7 349 S 7.47x47 Structure Structure
TM7 350 I 7.48x48 Structure Structure
TM7 351 N 7.49x49 Structure Structure
TM7 352 P 7.50x50 Structure Structure
TM7 353 I 7.51x51 Structure Structure
TM7 354 L 7.52x52 Structure Structure
TM7 355 Y 7.53x53 Structure Structure
TM7 356 N 7.54x54 Structure Structure
TM7 357 L 7.55x55 Structure Structure
TM7 358 I 7.56x56 Structure Structure
H8 359 S 8.47x47 Structure Structure
H8 360 K 8.48x48 Structure Structure
H8 361 K 8.49x49 Structure Structure
H8 362 Y 8.50x50 Structure Structure
H8 363 R 8.51x51 Structure Structure
H8 364 A 8.52x52 Structure Structure
H8 365 A 8.53x53 Structure Structure
H8 366 A 8.54x54 Structure Structure
H8 367 F 8.55x55 Structure Structure
H8 368 K 8.56x56 Structure Structure
H8 369 L 8.57x57 Structure Structure
H8 370 L 8.58x58 Structure Structure
H8 371 L 8.59x59 Structure Structure
H8 372 A 8.60x60 AF2 AF2
H8 373 R 8.61x61 AF2 AF2
H8 374 K 8.62x62 AF2 AF2
C-term 375 S - AF2 AF2
C-term 376 R - AF2 AF2
C-term 377 P - AF2 AF2
C-term 378 R - AF2 AF2
C-term 379 G - AF2 AF2
C-term 380 F - AF2 AF2
C-term 381 H - AF2 AF2
C-term 382 R - AF2 AF2
C-term 383 S - AF2 AF2
C-term 384 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 143 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 143 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 R 147 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic TM3 I 140 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM2 L 77 2x43 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 144 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM6 H 293 6x30 G.H5 L 349 G.H5.16
Hydrophobic ICL3 P 284 - G.H4 V 314 G.H4.16
Hydrophobic TM5 L 274 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM3 A 139 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 140 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 140 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 144 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 L 144 34x51 G.S3 V 199 G.S3.01
Hydrophobic ICL2 V 148 34x55 G.HN R 34 G.HN.52
Polar TM6 T 296 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 296 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 296 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM5 L 281 5x72 G.S6 H 327 G.S6.04
Van-der-waals TM5 L 281 5x72 G.S6 H 327 G.S6.04
Hydrophobic TM3 E 135 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 135 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 147 34x54 G.S1 L 40 G.S1.02
Polar ICL2 R 147 34x54 G.S1 E 39 G.S1.01
Hydrophobic ICL2 V 148 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 V 148 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 T 296 6x33 G.H5 L 353 G.H5.20
Polar ICL2 R 147 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 R 147 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 147 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 Q 295 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 L 300 6x37 G.H5 L 358 G.H5.25
Polar TM3 A 139 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM2 T 73 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 73 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 L 274 5x65 G.H5 L 349 G.H5.16
Van-der-waals TM5 L 274 5x65 G.H5 L 349 G.H5.16
Hydrophobic ICL3 A 285 - G.h4s6 I 323 G.h4s6.20
Polar TM3 R 136 3x50 G.H5 Y 356 G.H5.23
Polar TM2 N 74 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 N 74 2x40 G.H5 N 357 G.H5.24
Hydrophobic TM5 L 281 5x72 G.H5 F 339 G.H5.06
Hydrophobic TM3 I 140 3x54 G.H5 L 349 G.H5.16
Hydrophobic H8 K 360 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM3 I 140 3x54 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 143 34x50 G.H5 N 352 G.H5.19
Polar TM3 R 136 3x50 G.H5 N 357 G.H5.24
Polar H8 S 359 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 S 359 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 S 359 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM2 T 73 2x39 G.H5 N 357 G.H5.24
Van-der-waals TM2 T 73 2x39 G.H5 N 357 G.H5.24
Polar ICL2 R 147 34x54 G.hns1 A 36 G.hns1.01
Hydrophobic TM3 R 136 3x50 G.H5 L 358 G.H5.25