Refined structure (7Y15) of Gi1 - MRGPRD

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 188 from structure (53.1%), 166 from model (46.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure AF2
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure AF2
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure AF2
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure AF2
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure AF2
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 AF2 AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure AF2
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure AF2
G.H4 295 T G.H4.02 Structure AF2
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure AF2
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure AF2
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 264 from structure (86.6%), 41 from model (13.4%)
Residue sidechains - 250 from structure (82.0%), 55 from model (18.0%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 Q - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 N - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 S - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 V - AF2 AF2
N-term 12 E - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 A - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 N - AF2 AF2
N-term 17 Y - AF2 AF2
N-term 18 S - AF2 AF2
N-term 19 R - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 T - Structure Structure
N-term 23 V - Structure Structure
N-term 24 H - Structure Structure
N-term 25 T - Structure Structure
TM1 26 A 1.31x31 Structure Structure
TM1 27 Y 1.32x32 Structure Structure
TM1 28 L 1.33x33 Structure AF2
TM1 29 V 1.34x34 Structure Structure
TM1 30 L 1.35x35 Structure Structure
TM1 31 S 1.36x36 Structure Structure
TM1 32 S 1.37x37 Structure Structure
TM1 33 L 1.38x38 Structure Structure
TM1 34 A 1.39x39 Structure Structure
TM1 35 M 1.40x40 Structure Structure
TM1 36 F 1.41x41 Structure Structure
TM1 37 T 1.42x42 Structure Structure
TM1 38 C 1.43x43 Structure Structure
TM1 39 L 1.44x44 Structure Structure
TM1 40 C 1.45x45 Structure Structure
TM1 41 G 1.46x46 Structure Structure
TM1 42 M 1.47x47 Structure Structure
TM1 43 A 1.48x48 Structure Structure
TM1 44 G 1.49x49 Structure Structure
TM1 45 N 1.50x50 Structure Structure
TM1 46 S 1.51x51 Structure Structure
TM1 47 M 1.52x52 Structure Structure
TM1 48 V 1.53x53 Structure Structure
TM1 49 I 1.54x54 Structure Structure
TM1 50 W 1.55x55 Structure Structure
TM1 51 L 1.56x56 Structure Structure
TM1 52 L 1.57x57 Structure Structure
TM1 53 G 1.58x58 Structure Structure
TM1 54 F 1.59x59 Structure Structure
TM1 55 R 1.60x60 Structure AF2
TM1 56 M 1.61x61 Structure Structure
ICL1 57 H - Structure Structure
ICL1 58 R - Structure AF2
TM2 59 N 2.37x37 Structure Structure
TM2 60 P 2.38x38 Structure Structure
TM2 61 F 2.39x39 Structure Structure
TM2 62 C 2.40x40 Structure Structure
TM2 63 I 2.41x41 Structure Structure
TM2 64 Y 2.42x42 Structure Structure
TM2 65 I 2.43x43 Structure Structure
TM2 66 L 2.44x44 Structure Structure
TM2 67 N 2.45x45 Structure Structure
TM2 68 L 2.46x46 Structure Structure
TM2 69 A 2.47x47 Structure Structure
TM2 70 A 2.48x48 Structure Structure
TM2 71 A 2.49x49 Structure Structure
TM2 72 D 2.50x50 Structure Structure
TM2 73 L 2.51x51 Structure Structure
TM2 74 L 2.52x52 Structure Structure
TM2 75 F 2.53x53 Structure Structure
TM2 76 L 2.54x54 Structure Structure
TM2 77 F 2.55x55 Structure Structure
TM2 78 S 2.56x56 Structure Structure
TM2 79 M 2.57x57 Structure Structure
TM2 80 A 2.58x58 Structure Structure
TM2 81 S 2.59x59 Structure Structure
TM2 82 T 2.60x60 Structure Structure
TM2 83 L 2.61x61 Structure Structure
TM2 84 S 2.62x62 Structure Structure
TM2 85 L 2.63x63 Structure Structure
TM2 86 E 2.64x64 Structure Structure
TM2 87 T 2.65x65 Structure Structure
TM2 88 Q 2.66x66 Structure Structure
ECL1 89 P - Structure Structure
ECL1 90 L - Structure AF2
ECL1 91 V - Structure AF2
ECL1 92 N - Structure AF2
ECL1 93 T - Structure Structure
TM3 94 T 3.21x21 Structure Structure
TM3 95 D 3.22x22 Structure Structure
TM3 96 K 3.23x23 Structure Structure
TM3 97 V 3.24x24 Structure Structure
TM3 98 H 3.25x25 Structure Structure
TM3 99 E 3.26x26 Structure Structure
TM3 100 L 3.27x27 Structure Structure
TM3 101 M 3.28x28 Structure Structure
TM3 102 K 3.29x29 Structure Structure
TM3 103 R 3.30x30 Structure Structure
TM3 104 L 3.31x31 Structure Structure
TM3 105 M 3.32x32 Structure Structure
TM3 106 Y 3.33x33 Structure Structure
TM3 107 F 3.34x34 Structure Structure
TM3 108 A 3.35x35 Structure Structure
TM3 109 Y 3.36x36 Structure Structure
TM3 110 T 3.37x37 Structure Structure
TM3 111 V 3.38x38 Structure Structure
TM3 112 G 3.39x39 Structure Structure
TM3 113 L 3.40x40 Structure Structure
TM3 114 S 3.41x41 Structure Structure
TM3 115 L 3.42x42 Structure Structure
TM3 116 L 3.43x43 Structure Structure
TM3 117 T 3.44x44 Structure Structure
TM3 118 A 3.45x45 Structure Structure
TM3 119 I 3.46x46 Structure Structure
TM3 120 S 3.47x47 Structure Structure
TM3 121 T 3.48x48 Structure Structure
TM3 122 Q 3.49x49 Structure Structure
TM3 123 R 3.50x50 Structure Structure
TM3 124 C 3.51x51 Structure Structure
TM3 125 L 3.52x52 Structure Structure
TM3 126 S 3.53x53 Structure Structure
TM3 127 V 3.54x54 Structure Structure
TM3 128 L 3.55x55 Structure Structure
TM3 129 F 3.56x56 Structure Structure
ICL2 130 P 34.50x50 Structure Structure
ICL2 131 I 34.51x51 Structure Structure
ICL2 132 W 34.52x52 Structure Structure
ICL2 133 F 34.53x53 Structure Structure
ICL2 134 K 34.54x54 Structure Structure
ICL2 135 C 34.55x55 Structure Structure
ICL2 136 H 34.56x56 Structure Structure
ICL2 137 R 34.57x57 Structure Structure
TM4 138 P 4.38x38 Structure Structure
TM4 139 R 4.39x39 Structure Structure
TM4 140 H 4.40x40 Structure Structure
TM4 141 L 4.41x41 Structure Structure
TM4 142 S 4.42x42 Structure Structure
TM4 143 A 4.43x43 Structure Structure
TM4 144 W 4.44x44 Structure Structure
TM4 145 V 4.45x45 Structure Structure
TM4 146 C 4.46x46 Structure Structure
TM4 147 G 4.47x47 Structure Structure
TM4 148 L 4.48x48 Structure Structure
TM4 149 L 4.49x49 Structure Structure
TM4 150 W 4.50x50 Structure Structure
TM4 151 T 4.51x51 Structure Structure
TM4 152 L 4.52x52 Structure Structure
TM4 153 C 4.53x53 Structure Structure
TM4 154 L 4.54x54 Structure Structure
TM4 155 L 4.55x55 Structure Structure
TM4 156 M 4.56x56 Structure Structure
TM4 157 N 4.57x57 Structure Structure
TM4 158 G 4.58x58 Structure Structure
TM4 159 L 4.59x59 Structure Structure
TM4 160 T 4.60x60 Structure Structure
TM4 161 S 4.61x61 Structure Structure
TM4 162 S 4.62x62 Structure Structure
TM4 163 F 4.63x63 Structure Structure
TM4 164 C 4.64x64 Structure Structure
ECL2 165 S - Structure Structure
ECL2 166 K - Structure AF2
ECL2 167 F - Structure AF2
ECL2 168 L - Structure Structure
ECL2 169 K - Structure Structure
ECL2 170 F - Structure AF2
ECL2 171 N - Structure Structure
ECL2 172 E - Structure AF2
ECL2 173 D - Structure AF2
TM5 174 R 5.32x33 Structure Structure
TM5 175 C 5.33x34 Structure Structure
TM5 176 F 5.34x35 Structure Structure
TM5 177 R 5.35x36 Structure Structure
TM5 178 V 5.36x37 Structure Structure
TM5 179 D 5.37x38 Structure Structure
TM5 180 M 5.38x39 Structure Structure
TM5 181 V 5.39x40 Structure Structure
TM5 182 Q 5.40x41 Structure Structure
TM5 183 A 5.41x42 Structure Structure
TM5 184 A 5.42x43 Structure Structure
TM5 185 L 5.43x44 Structure Structure
TM5 186 I 5.44x45 Structure Structure
TM5 187 M 5.45x46 Structure AF2
TM5 188 G 5.46x461 Structure Structure
TM5 189 V 5.47x47 Structure Structure
TM5 190 L 5.48x48 Structure Structure
TM5 191 T 5.49x49 Structure Structure
TM5 192 P 5.50x50 Structure Structure
TM5 193 V 5.51x51 Structure Structure
TM5 194 M 5.52x52 Structure Structure
TM5 195 T 5.53x53 Structure Structure
TM5 196 L 5.54x54 Structure Structure
TM5 197 S 5.55x55 Structure Structure
TM5 198 S 5.56x56 Structure Structure
TM5 199 L 5.57x57 Structure Structure
TM5 200 T 5.58x58 Structure Structure
TM5 201 L 5.59x59 Structure Structure
TM5 202 F 5.60x60 Structure Structure
TM5 203 V 5.61x61 Structure Structure
TM5 204 W 5.62x62 Structure Structure
TM5 205 V 5.63x63 Structure Structure
TM5 206 R 5.64x64 Structure Structure
TM5 207 R 5.65x65 Structure Structure
TM5 208 S 5.66x66 Structure Structure
TM5 209 S 5.67x67 Structure Structure
ICL3 210 Q - Structure AF2
ICL3 211 Q - Structure Structure
ICL3 212 W - Structure Structure
ICL3 213 R - Structure Structure
ICL3 214 R - Structure Structure
TM6 215 Q 6.29x29 Structure Structure
TM6 216 P 6.30x30 Structure Structure
TM6 217 T 6.31x31 Structure Structure
TM6 218 R 6.32x32 Structure Structure
TM6 219 L 6.33x33 Structure Structure
TM6 220 F 6.34x34 Structure Structure
TM6 221 V 6.35x35 Structure Structure
TM6 222 V 6.36x36 Structure Structure
TM6 223 V 6.37x37 Structure Structure
TM6 224 L 6.38x38 Structure Structure
TM6 225 A 6.39x39 Structure Structure
TM6 226 S 6.40x40 Structure Structure
TM6 227 V 6.41x41 Structure Structure
TM6 228 L 6.42x42 Structure Structure
TM6 229 V 6.43x43 Structure Structure
TM6 230 F 6.44x44 Structure Structure
TM6 231 L 6.45x45 Structure Structure
TM6 232 I 6.46x46 Structure Structure
TM6 233 C 6.47x47 Structure Structure
TM6 234 S 6.48x48 Structure Structure
TM6 235 L 6.49x49 Structure Structure
TM6 236 P 6.50x50 Structure Structure
TM6 237 L 6.51x51 Structure Structure
TM6 238 S 6.52x52 Structure Structure
TM6 239 I 6.53x53 Structure Structure
TM6 240 Y 6.54x54 Structure Structure
TM6 241 W 6.55x55 Structure Structure
TM6 242 F 6.56x56 Structure Structure
TM6 243 V 6.57x57 Structure Structure
TM6 244 L 6.58x58 Structure Structure
TM6 245 Y 6.59x59 Structure Structure
TM6 246 W 6.60x60 Structure Structure
TM6 247 L 6.61x61 Structure Structure
ECL3 248 S - Structure Structure
ECL3 249 L - Structure Structure
ECL3 250 P - Structure Structure
ECL3 251 P - Structure Structure
ECL3 252 E - Structure AF2
ECL3 253 M - Structure Structure
TM7 254 Q 7.31x30 Structure Structure
TM7 255 V 7.32x31 Structure Structure
TM7 256 L 7.33x32 Structure Structure
TM7 257 C 7.34x33 Structure Structure
TM7 258 F 7.35x34 Structure Structure
TM7 259 S 7.36x35 Structure Structure
TM7 260 L 7.37x36 Structure Structure
TM7 261 S 7.38x37 Structure Structure
TM7 262 R 7.39x38 Structure Structure
TM7 263 L 7.40x39 Structure Structure
TM7 264 S 7.41x40 Structure Structure
TM7 265 S 7.42x41 Structure Structure
TM7 266 S 7.43x42 Structure Structure
TM7 267 V 7.44x43 Structure Structure
TM7 268 S 7.45x45 Structure Structure
TM7 269 S 7.46x46 Structure Structure
TM7 270 S 7.47x47 Structure Structure
TM7 271 A 7.48x48 Structure Structure
TM7 272 N 7.49x49 Structure Structure
TM7 273 P 7.50x50 Structure Structure
TM7 274 V 7.51x51 Structure Structure
TM7 275 I 7.52x52 Structure Structure
TM7 276 Y 7.53x53 Structure Structure
TM7 277 F 7.54x54 Structure Structure
TM7 278 L 7.55x55 Structure Structure
TM7 279 V 7.56x56 Structure Structure
H8 280 G 8.47x47 Structure Structure
H8 281 S 8.48x48 Structure Structure
H8 282 R 8.49x49 Structure Structure
H8 283 R 8.50x50 Structure Structure
H8 284 S 8.51x51 Structure Structure
H8 285 H 8.52x52 Structure Structure
H8 286 R 8.53x53 AF2 AF2
H8 287 L 8.54x54 AF2 AF2
H8 288 P 8.55x55 AF2 AF2
H8 289 T 8.56x56 AF2 AF2
H8 290 R 8.57x57 AF2 AF2
H8 291 S 8.58x58 AF2 AF2
H8 292 L 8.59x59 AF2 AF2
H8 293 G 8.60x60 AF2 AF2
H8 294 T 8.61x61 AF2 AF2
H8 295 V 8.62x62 AF2 AF2
C-term 296 L - AF2 AF2
C-term 297 Q - AF2 AF2
C-term 298 Q - AF2 AF2
C-term 299 A - AF2 AF2
C-term 300 L - AF2 AF2
C-term 301 R - AF2 AF2
C-term 302 E - AF2 AF2
C-term 303 E - AF2 AF2
C-term 304 P - AF2 AF2
C-term 305 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term R 301 - G.H2 S 206 G.H2.02
Hydrophobic C-term R 301 - G.H2 S 206 G.H2.02
Van-der-waals C-term R 301 - G.H2 S 206 G.H2.02
Hydrophobic ICL2 K 134 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 K 134 34x54 G.H5 I 343 G.H5.15
Polar TM6 R 218 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 218 6x32 G.H5 F 354 G.H5.26
Polar C-term Q 297 - G.H2 S 206 G.H2.02
Hydrophobic C-term Q 297 - G.H2 S 206 G.H2.02
Van-der-waals C-term Q 297 - G.H2 S 206 G.H2.02
Hydrophobic C-term E 303 - G.s4h3 E 236 G.s4h3.10
Hydrophobic C-term L 296 - G.H2 I 212 G.H2.08
Van-der-waals C-term L 296 - G.H2 I 212 G.H2.08
Polar H8 S 291 8x58 G.H2 K 210 G.H2.06
Hydrophobic H8 S 291 8x58 G.H2 K 210 G.H2.06
Van-der-waals H8 S 291 8x58 G.H2 K 210 G.H2.06
Hydrophobic TM3 R 123 3x50 G.H5 L 353 G.H5.25
Hydrophobic C-term A 299 - G.H3 L 249 G.H3.08
Van-der-waals C-term A 299 - G.H3 L 249 G.H3.08
Hydrophobic H8 L 292 8x59 G.H3 F 259 G.H3.18
Van-der-waals H8 L 292 8x59 G.H3 F 259 G.H3.18
Hydrophobic C-term L 300 - G.S1 L 39 G.S1.07
Hydrophobic H8 L 292 8x59 G.H2 K 210 G.H2.06
Hydrophobic C-term L 300 - G.s1h1 G 40 G.s1h1.01
Van-der-waals C-term L 300 - G.s1h1 G 40 G.s1h1.01
Hydrophobic C-term A 299 - G.H2 R 208 G.H2.04
Van-der-waals C-term A 299 - G.H2 R 208 G.H2.04
Polar H8 R 290 8x57 G.H3 W 258 G.H3.17
Hydrophobic H8 R 290 8x57 G.H3 W 258 G.H3.17
Van-der-waals H8 R 290 8x57 G.H3 W 258 G.H3.17
Hydrophobic ICL2 K 134 34x54 G.S1 E 33 G.S1.01
Hydrophobic C-term L 296 - G.S1 L 39 G.S1.07
Van-der-waals C-term L 296 - G.S1 L 39 G.S1.07
Hydrophobic C-term E 302 - G.H3 E 245 G.H3.04
Van-der-waals C-term E 302 - G.H3 E 245 G.H3.04
Hydrophobic H8 L 292 8x59 G.H3 N 256 G.H3.15
Van-der-waals H8 L 292 8x59 G.H3 N 256 G.H3.15
Hydrophobic C-term L 296 - G.S3 V 201 G.S3.08
Polar H8 S 291 8x58 G.H3 W 258 G.H3.17
Hydrophobic H8 S 291 8x58 G.H3 W 258 G.H3.17
Hydrophobic H8 G 293 8x60 G.H2 E 207 G.H2.03
Van-der-waals H8 G 293 8x60 G.H2 E 207 G.H2.03
Polar H8 L 292 8x59 G.H2 H 213 G.H2.09
Hydrophobic H8 L 292 8x59 G.H2 H 213 G.H2.09
Van-der-waals H8 L 292 8x59 G.H2 H 213 G.H2.09
Hydrophobic ICL2 F 133 34x53 G.H5 N 347 G.H5.19
Polar H8 L 292 8x59 G.H2 K 209 G.H2.05
Hydrophobic H8 L 292 8x59 G.H2 K 209 G.H2.05
Van-der-waals H8 L 292 8x59 G.H2 K 209 G.H2.05
Hydrophobic H8 R 290 8x57 G.H2 H 213 G.H2.09
Van-der-waals H8 R 290 8x57 G.H2 H 213 G.H2.09
Polar H8 S 291 8x58 G.H2 H 213 G.H2.09
Hydrophobic H8 S 291 8x58 G.H2 H 213 G.H2.09
Van-der-waals H8 S 291 8x58 G.H2 H 213 G.H2.09
Hydrophobic ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Hydrophobic C-term Q 298 - G.H2 R 208 G.H2.04
Van-der-waals C-term Q 298 - G.H2 R 208 G.H2.04
Polar H8 S 291 8x58 G.H2 K 209 G.H2.05
Hydrophobic H8 S 291 8x58 G.H2 K 209 G.H2.05
Van-der-waals H8 S 291 8x58 G.H2 K 209 G.H2.05
Ionic C-term R 301 - G.H2 E 207 G.H2.03
Polar C-term R 301 - G.H2 E 207 G.H2.03
Hydrophobic C-term R 301 - G.H2 E 207 G.H2.03
Van-der-waals C-term R 301 - G.H2 E 207 G.H2.03
Van-der-waals ICL3 R 213 - G.H5 K 345 G.H5.17
Polar H8 V 295 8x62 G.H2 R 208 G.H2.04
Hydrophobic H8 V 295 8x62 G.H2 R 208 G.H2.04
Van-der-waals H8 V 295 8x62 G.H2 R 208 G.H2.04
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 223 6x37 G.H5 L 353 G.H5.25
Hydrophobic C-term L 296 - G.S1 L 37 G.S1.05
Hydrophobic C-term P 304 - G.H3 E 245 G.H3.04
Van-der-waals C-term P 304 - G.H3 E 245 G.H3.04
Ionic C-term E 302 - G.H3 K 248 G.H3.07
Hydrophobic C-term E 302 - G.H3 K 248 G.H3.07
Van-der-waals C-term E 302 - G.H3 K 248 G.H3.07
Polar H8 T 294 8x61 G.H2 E 207 G.H2.03
Hydrophobic H8 T 294 8x61 G.H2 E 207 G.H2.03
Van-der-waals H8 T 294 8x61 G.H2 E 207 G.H2.03
Hydrophobic TM6 V 222 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 222 6x36 G.H5 L 353 G.H5.25
Polar C-term L 296 - G.H2 R 208 G.H2.04
Hydrophobic C-term L 296 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 296 - G.H2 R 208 G.H2.04
Polar TM2 N 59 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 N 59 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 59 2x37 G.H5 D 350 G.H5.22
Polar C-term E 305 - G.s4h3 D 237 G.s4h3.11
Hydrophobic C-term E 305 - G.s4h3 D 237 G.s4h3.11
Van-der-waals C-term E 305 - G.s4h3 D 237 G.s4h3.11
Hydrophobic TM6 L 219 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 219 6x33 G.H5 L 348 G.H5.20
Hydrophobic C-term P 304 - G.s4h3 D 237 G.s4h3.11
Van-der-waals C-term P 304 - G.s4h3 D 237 G.s4h3.11
Hydrophobic H8 L 292 8x59 G.H2 W 211 G.H2.07
Van-der-waals H8 L 292 8x59 G.H2 W 211 G.H2.07
Hydrophobic C-term L 296 - G.H3 I 253 G.H3.12
Van-der-waals C-term L 296 - G.H3 I 253 G.H3.12
Polar H8 T 294 8x61 G.H2 R 208 G.H2.04
Hydrophobic H8 T 294 8x61 G.H2 R 208 G.H2.04
Van-der-waals H8 T 294 8x61 G.H2 R 208 G.H2.04
Hydrophobic C-term L 300 - G.S3 V 201 G.S3.08
Van-der-waals C-term L 300 - G.S3 V 201 G.S3.08
Hydrophobic ICL3 R 214 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 R 214 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 K 134 34x54 G.hns1 R 32 G.hns1.03
Polar H8 P 288 8x55 G.h2s4 E 216 G.h2s4.02
Hydrophobic H8 P 288 8x55 G.h2s4 E 216 G.h2s4.02
Van-der-waals H8 P 288 8x55 G.h2s4 E 216 G.h2s4.02
Hydrophobic TM2 F 61 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 F 61 2x39 G.H5 D 350 G.H5.22
Hydrophobic H8 G 280 8x47 G.H5 C 351 G.H5.23
Polar H8 G 293 8x60 G.H2 W 211 G.H2.07
Hydrophobic H8 G 293 8x60 G.H2 W 211 G.H2.07
Van-der-waals H8 G 293 8x60 G.H2 W 211 G.H2.07
Polar C-term Q 298 - G.H2 S 206 G.H2.02
Hydrophobic ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Hydrophobic C-term P 304 - G.s4h3 M 240 G.s4h3.14
Van-der-waals C-term P 304 - G.s4h3 M 240 G.s4h3.14
Hydrophobic TM7 V 279 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 279 7x56 G.H5 G 352 G.H5.24
Polar H8 T 289 8x56 G.h2s4 E 216 G.h2s4.02
Polar H8 G 293 8x60 G.H2 K 209 G.H2.05
Hydrophobic H8 G 293 8x60 G.H2 K 209 G.H2.05
Van-der-waals H8 G 293 8x60 G.H2 K 209 G.H2.05
Polar H8 T 294 8x61 G.H2 K 209 G.H2.05
Hydrophobic H8 T 294 8x61 G.H2 K 209 G.H2.05
Van-der-waals H8 T 294 8x61 G.H2 K 209 G.H2.05
Polar C-term Q 297 - G.H2 W 211 G.H2.07
Hydrophobic C-term Q 297 - G.H2 W 211 G.H2.07
Van-der-waals C-term Q 297 - G.H2 W 211 G.H2.07
Ionic C-term E 303 - G.hfs2 K 180 G.hfs2.04
Polar TM6 R 218 6x32 G.H5 G 352 G.H5.24
Polar H8 G 293 8x60 G.H2 R 208 G.H2.04
Hydrophobic H8 G 293 8x60 G.H2 R 208 G.H2.04
Van-der-waals H8 G 293 8x60 G.H2 R 208 G.H2.04
Hydrophobic TM3 V 127 3x54 G.H5 I 344 G.H5.16
Polar C-term R 301 - G.H2 R 205 G.H2.01
Hydrophobic C-term R 301 - G.H2 R 205 G.H2.01
Van-der-waals C-term R 301 - G.H2 R 205 G.H2.01
Hydrophobic TM6 R 218 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 218 6x32 G.H5 L 353 G.H5.25
Hydrophobic C-term A 299 - G.H3 S 252 G.H3.11
Van-der-waals C-term A 299 - G.H3 S 252 G.H3.11
Polar H8 V 295 8x62 G.H3 S 252 G.H3.11
Hydrophobic H8 L 292 8x59 G.H2 R 208 G.H2.04
Van-der-waals H8 L 292 8x59 G.H2 R 208 G.H2.04
Polar C-term Q 297 - G.H2 R 208 G.H2.04
Hydrophobic C-term Q 297 - G.H2 R 208 G.H2.04
Van-der-waals C-term Q 297 - G.H2 R 208 G.H2.04
Hydrophobic C-term P 304 - G.s4h3 E 236 G.s4h3.10
Hydrophobic H8 T 289 8x56 G.H3 W 258 G.H3.17
Van-der-waals H8 T 289 8x56 G.H3 W 258 G.H3.17
Ionic H8 R 286 8x53 G.h3s5 D 261 G.h3s5.02
Polar H8 R 286 8x53 G.h3s5 D 261 G.h3s5.02
Van-der-waals H8 R 286 8x53 G.h3s5 D 261 G.h3s5.02
Polar ICL2 K 134 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 F 61 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 205 5x63 G.H5 L 348 G.H5.20
Hydrophobic C-term Q 297 - G.s3h2 Q 204 G.s3h2.03
Van-der-waals C-term Q 297 - G.s3h2 Q 204 G.s3h2.03
Hydrophobic H8 R 283 8x50 G.H5 K 349 G.H5.21
Van-der-waals H8 R 283 8x50 G.H5 K 349 G.H5.21
Hydrophobic H8 V 295 8x62 G.H2 K 209 G.H2.05
Van-der-waals H8 V 295 8x62 G.H2 K 209 G.H2.05
Hydrophobic C-term L 300 - G.H3 L 249 G.H3.08
Van-der-waals C-term L 300 - G.H3 L 249 G.H3.08
Hydrophobic H8 T 294 8x61 G.H2 K 210 G.H2.06
Van-der-waals H8 T 294 8x61 G.H2 K 210 G.H2.06
Ionic TM4 R 139 4x39 G.HN E 28 G.HN.52
Polar TM4 R 139 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 R 139 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 R 139 4x39 G.HN E 28 G.HN.52
Hydrophobic C-term P 304 - G.s4h3 L 234 G.s4h3.08
Van-der-waals C-term P 304 - G.s4h3 L 234 G.s4h3.08
Hydrophobic H8 L 292 8x59 G.H3 W 258 G.H3.17
Van-der-waals H8 L 292 8x59 G.H3 W 258 G.H3.17
Hydrophobic C-term L 296 - G.H3 L 249 G.H3.08
Polar C-term Q 297 - G.H2 E 207 G.H2.03
Hydrophobic C-term Q 297 - G.H2 E 207 G.H2.03
Van-der-waals C-term Q 297 - G.H2 E 207 G.H2.03
Hydrophobic H8 G 293 8x60 G.H2 I 212 G.H2.08
Van-der-waals H8 G 293 8x60 G.H2 I 212 G.H2.08
Ionic ICL3 R 213 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 213 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 213 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 213 - G.h4s6 E 318 G.h4s6.12
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic C-term L 300 - G.s3h2 G 202 G.s3h2.01
Van-der-waals C-term L 300 - G.s3h2 G 202 G.s3h2.01
Polar H8 G 293 8x60 G.H2 K 210 G.H2.06
Hydrophobic H8 G 293 8x60 G.H2 K 210 G.H2.06
Van-der-waals H8 G 293 8x60 G.H2 K 210 G.H2.06
Polar TM6 L 219 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 219 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 219 6x33 G.H5 L 353 G.H5.25
Polar TM3 S 126 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 131 34x51 G.S3 L 194 G.S3.01
Polar ICL2 C 135 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 C 135 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 L 201 5x59 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 134 34x54 G.S1 V 34 G.S1.02
Hydrophobic H8 G 280 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 280 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 P 216 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 P 216 6x30 G.H5 F 354 G.H5.26
Polar H8 L 292 8x59 G.H2 I 212 G.H2.08
Hydrophobic H8 L 292 8x59 G.H2 I 212 G.H2.08
Van-der-waals H8 L 292 8x59 G.H2 I 212 G.H2.08
Van-der-waals C-term L 296 - G.H2 K 209 G.H2.05
Polar ICL2 C 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 135 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 131 34x51 G.H5 I 343 G.H5.15
Hydrophobic C-term L 296 - G.H2 W 211 G.H2.07
Van-der-waals C-term L 296 - G.H2 W 211 G.H2.07
Hydrophobic TM5 L 201 5x59 G.H5 L 348 G.H5.20
Ionic ICL3 R 213 - G.H5 D 341 G.H5.13
Polar ICL3 R 213 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 213 - G.H5 D 341 G.H5.13
Polar H8 R 283 8x50 G.H5 F 354 G.H5.26
Hydrophobic H8 R 283 8x50 G.H5 F 354 G.H5.26
Van-der-waals H8 R 283 8x50 G.H5 F 354 G.H5.26
Hydrophobic H8 V 295 8x62 G.H2 I 212 G.H2.08
Polar TM3 S 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term L 300 - G.H2 W 211 G.H2.07